DDI Extraction Based on Transfer Weight Matrix and Memory Network

Extracting drug-drug interaction (DDI) in the text is the process of identifying how two target drugs in a given sentence interact. Previous methods, which were limited to conventional machine learning techniques, we are susceptible to issues such as “vocabulary gap” and unattainable automation processes in feature extraction. Inspired by deep learning in natural language preprocessing, we addressed the aforementioned problems based on dynamic transfer matrix and memory networks. A TM-RNN method is proposed by adding the transfer weight matrix in multilayer bidirectional LSTM to improve robustness and introduce a memory network for feature fusion. We evaluated the TM-RNN model on the DDIExtraction 2013 Task. The proposed model achieved an overall F-score of 72.43, which outperforms the latest methods based on support vector machine and other neural networks. Meanwhile, the experimental results also indicated that the proposed model is more stable and less affected by negative samples

Discriminating different scenarios to account for the cosmic e±e^\pm excess by synchrotron and inverse Compton radiation

The excesses of the cosmic positron fraction recently measured by PAMELA and the electron spectra by ATIC, PPB-BETS, Fermi and H.E.S.S. indicate the existence of primary electron and positron sources. The possible explanations include dark matter annihilation, decay, and astrophysical origin, like pulsars. In this work we show that these three scenarios can all explain the experimental results of the cosmic $e^\pm$ excess. However, it may be difficult to discriminate these different scenarios by the local measurements of electrons and positrons. We propose possible discriminations among these scenarios through the synchrotron and inverse Compton radiation of the primary electrons/positrons from the region close to the Galactic center. Taking typical configurations, we find the three scenarios predict quite different spectra and skymaps of the synchrotron and inverse Compton radiation, though there are relatively large uncertainties. The most prominent differences come from the energy band $10^4\sim 10^9$ MHz for synchrotron emission and $\gtrsim 10$ GeV for inverse Compton emission. It might be able to discriminate at least the annihilating dark matter scenario from the other two given the high precision synchrotron and diffuse $\gamma$-ray skymaps in the future.Comment: published in Pr

Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling.

Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced cardiac apoptosis in vivo and in vitro via regulating HIF-1α signalling pathway. Rat myocardial I/R was induced by occluding the left anterior descending artery for 30 minutes followed by 6-hours reperfusion, and cardiomyocyte hypoxia/reoxygenation (H/R) was induced by oxygen-glucose deprivation for 6 hours followed by 3-hours reoxygenation. Dexmedetomidine administration at the beginning of reperfusion or reoxygenation attenuated I/R-induced myocardial injury or H/R-induced cell death, alleviated mitochondrial dysfunction, reduced the number of apoptotic cardiomyocytes, inhibited the activation of HIF-1α and modulated the expressions of apoptosis-related proteins including BCL-2, BAX, BNIP3, cleaved caspase-3 and cleaved PARP. Conversely, the HIF-1α prolyl hydroxylase-2 inhibitor IOX2 partly blocked DEX-mediated cardioprotection both in vivo and in vitro. Mechanistically, DEX down-regulated HIF-1α expression at the post-transcriptional level and inhibited the transcriptional activation of the target gene BNIP3. Post-treatment with DEX protects against cardiac I/R injury in vivo and H/R injury in vitro. These effects are, at least in part, mediated via the inhibition of cell apoptosis by targeting HIF-1α signalling

Long-range dependence and multifractality of ship flow sequences in container ports : A comparison of Shanghai, Singapore, and Rotterdam

The prediction of ship traffic flow is an important fundamental preparation for layout and design of ports as well as management of ship navigation. However, until now, the temporal characteristics and accurate prediction of ship flow sequence in port are rarely studied. Therefore, in this study, we investigated the presence of long-range dependence in container ship flow sequences using the Multifractal Detrended Fluctuation Analysis (MF-DFA). We considered three representative container ports in the world—including Shanghai, Singapore, and Rotterdam container ports—as the study sample, from 1 January 2013 to 31 December 2017. Empirical results suggested that the ship flow sequences are deviated from normal distribution, and the sequences with different time scales exhibited varying degrees of long-range dependence. Furthermore, the ship flow sequences possessed a multifractal nature, where the larger the time scale of ship flow time series, the stronger the multifractal characteristics are. The weekly ship flow sequence in the port of Singapore owned the highest degree of multifractality. Furthermore, the multifractality presented in the ship flow sequences of container ports are due to the correlation properties as well as the probability density function of the ship flow sequences. The study outlines the importance of adopting these features for an accurate modeling and prediction for maritime ship flow series

Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling.

BackgroundHeat shock protein 70 (Hsp70) has been shown to exert cardioprotection. Intracellular calcium ([Ca2+]i) overload induced by p38 mitogen-activated protein kinase (p38 MAPK) activation contributes to cardiac ischemia/reperfusion (I/R) injury. However, whether Hsp70 interacts with p38 MAPK signaling is unclear. Therefore, this study investigated the regulation of p38 MAPK by Hsp70 in I/R-induced cardiac injury.MethodsNeonatal rat cardiomyocytes were subjected to oxygen-glucose deprivation for 6 h followed by 2 h reoxygenation (OGD/R), and rats underwent left anterior artery ligation for 30 min followed by 30 min of reperfusion. The p38 MAPK inhibitor (SB203580), Hsp70 inhibitor (Quercetin), and Hsp70 short hairpin RNA (shRNA) were used prior to OGD/R or I/R. Cell viability, lactate dehydrogenase (LDH) release, serum cardiac troponin I (cTnI), [Ca2+]i levels, cell apoptosis, myocardial infarct size, mRNA level of IL-1β and IL-6, and protein expression of Hsp70, phosphorylated p38 MAPK (p-p38 MAPK), sarcoplasmic/endoplasmic reticulum Ca2+-ATPase2 (SERCA2), phosphorylated signal transducer and activator of transcription3 (p-STAT3), and cleaved caspase3 were assessed.ResultsPretreatment with a p38 MAPK inhibitor, SB203580, significantly attenuated OGD/R-induced cell injury or I/R-induced myocardial injury, as evidenced by improved cell viability and lower LDH release, resulted in lower serum cTnI and myocardial infarct size, alleviation of [Ca2+]i overload and cell apoptosis, inhibition of IL-1β and IL-6, and modulation of protein expressions of p-p38 MAPK, SERCA2, p-STAT3, and cleaved-caspase3. Knockdown of Hsp70 by shRNA exacerbated OGD/R-induced cell injury, which was effectively abolished by SB203580. Moreover, inhibition of Hsp70 by quercetin enhanced I/R-induced myocardial injury, while SB203580 pretreatment reversed the harmful effects caused by quercetin.ConclusionsInhibition of Hsp70 aggravates [Ca2+]i overload, inflammation, and apoptosis through regulating p38 MAPK signaling during cardiac I/R injury, which may help provide novel insight into cardioprotective strategies

Qualitative and quantitative analysis of catechin and quercetin in flavonoids extracted from Rosa roxburghii Tratt

Purpose: To perform a qualitative and quantitative analysis of catechin and quercetin in flavonoids extracted from Rosa roxburghii Tratt.Methods: Total flavonoids were determined using ultraviolet spectrophotometry (UV) at 500 nm. The optimal gradient program started with 15 % methanol and was kept within a period of 0 – 20 min, while 25 % methanol was kept within 20 – 33 min. Subsequently, the concentration of methanol was reduced to 15 % and was held for 10 min until the next injection. Mass spectrometry spray voltage was 4,000 V, ionization temperature 350 °C, atomizer pressure 35 psi, nitrogen flow rate 8 L/min, and mass scan range 200 – 800 m/z. The detection wavelength used for catechin and quercetin was 270 and 368 nm, respectively.Results: Based on the UV results, Rosa roxburghii Tratt content was 73.85 %, which is in agreement with the national standard. Liquid chromatography-mass spectrometry (LC-MS) results indicate that Rosa roxburghii Tratt flavonoids contained quercetin, 34.26 %, with relative standard deviation (RSD) of 2.88 % and catechin content of 2.97 % with RSD of 1.49 %.Conclusion: The proposed measurement method for determining the content of flavonoids in Rosa roxburghii Tratt has the advantage of simplicity, feasibility, good repeatability, and rapid and accurate analysis.Keywords: Rosa roxburghii Tratt, Flavonoids, Catechin, Querceti