Similarity of ionized gas nebulae around unobscured and obscured quasars

Quasar feedback is suspected to play a key role in the evolution of massive galaxies, by removing or reheating gas in quasar host galaxies and thus limiting the amount of star formation. In this paper we continue our investigation of quasar-driven winds on galaxy-wide scales. We conduct Gemini Integral Field Unit spectroscopy of a sample of luminous unobscured (type 1) quasars, to determine the morphology and kinematics of ionized gas around these objects, predominantly via observations of the [O III]5007 emission line. We find that ionized gas nebulae extend out to ~13 kpc from the quasar, that they are smooth and round, and that their kinematics are inconsistent with gas in dynamical equilibrium with the host galaxy. The observed morphological and kinematic properties are strikingly similar to those of ionized gas around obscured (type 2) quasars with matched [O III] luminosity, with marginal evidence that nebulae around unobscured quasars are slightly more compact. Therefore in samples of obscured and unobscured quasars carefully matched in [O III] luminosity we find support for the standard geometry-based unification model of active galactic nuclei, in that the intrinsic properties of quasars, of their hosts and of their ionized gas appear to be very similar. Given the apparent ubiquity of extended ionized regions, we are forced to conclude that either the quasar is at least partially illuminating pre-existing gas or that both samples of quasars are seen during advanced stages of quasar feedback. In the latter case, we may be biased by our [O III]-based selection against quasars in the early "blow-out" phase, for example due to dust obscuration.Comment: 17 pages, 10 figures, 2 tables. Published in MNRAS, 201

Observations of Feedback from Radio-Quiet Quasars: I. Extents and Morphologies of Ionized Gas Nebulae

Black hole feedback -- the strong interaction between the energy output of supermassive black holes and their surrounding environments -- is routinely invoked to explain the absence of overly luminous galaxies, the black hole vs. bulge correlations and the similarity of black hole accretion and star formation histories. Yet direct probes of this process in action are scarce and limited to small samples of active nuclei. We present Gemini IFU observations of the distribution of ionized gas around luminous, obscured, radio-quiet (RQ) quasars at z~0.5. We detect extended ionized gas nebulae via [O III]5007 emission in every case, with a mean diameter of 28 kpc. These nebulae are nearly perfectly round. The regular morphologies of nebulae around RQ quasars are in striking contrast with lumpy or elongated nebulae seen around radio galaxies at low and high redshifts. We present the uniformly measured size-luminosity relationship of [O III] nebulae around Seyfert 2 galaxies and type 2 quasars spanning 6 orders of magnitude in luminosity and confirm the flat slope of the correlation (R ~ L^{0.25+/-0.02}). We find a universal behavior of the [O III]/H-beta ratio in our entire RQ quasar sample: it persists at a constant value (~10) in the central regions, until reaching a "break" isophotal radius ranging from 4 to 11 kpc where it starts to decrease. We propose a model of clumpy nebulae in which clouds that produce line emission transition from being ionization-bounded at small distances from the quasar to being matter-bounded in the outer parts of the nebula, which qualitatively explains the observed line ratio and surface brightness profiles. It is striking that we see such smooth and round large-scale gas nebulosities in this sample, which are inconsistent with illuminated merger debris and which we suggest may be the signature of accretion energy from the nucleus reaching gas at large scales.Comment: 44 pages, 11 figures, 3 tables. Accepted for publication in MNRA

Observations of Feedback from Radio-Quiet Quasars - II. Kinematics of Ionized Gas Nebulae

The prevalence and energetics of quasar feedback is a major unresolved problem in galaxy formation theory. In this paper, we present Gemini Integral Field Unit observations of ionized gas around eleven luminous, obscured, radio-quiet quasars at z~0.5 out to ~15 kpc from the quasar; specifically, we measure the kinematics and morphology of [O III]5007 emission. The round morphologies of the nebulae and the large line-of-sight velocity widths (with velocities containing 80% of the emission as high as 1000 km/s combined with relatively small velocity difference across them (from 90 to 520 km/s) point toward wide-angle quasi-spherical outflows. We use the observed velocity widths to estimate a median outflow velocity of 760 km/s, similar to or above the escape velocities from the host galaxies. The line-of-sight velocity dispersion declines slightly toward outer parts of the nebulae (by 3% per kpc on average). The majority of nebulae show blueshifted excesses in their line profiles across most of their extents, signifying gas outflows. For the median outflow velocity, we find a kinetic energy flow between 4x10^{44} and 3x10^{45} erg/s and mass outflow rate between 2000 and 20000 Msun/yr. These values are large enough for the observed quasar winds to have a significant impact on their host galaxies. The median rate of converting bolometric luminosity to kinetic energy of ionized gas clouds is ~2%. We report four new candidates for "super-bubbles" -- outflows that may have broken out of the denser regions of the host galaxy.Comment: 23 pages, 10 figures, 2 tables, accepted for publication in MNRA

Beneficial effects of childhood selective dorsal rhizotomy in adulthood

Background: Selective dorsal rhizotomy (SDR) has been used to treat children with spastic cerebral palsy (CP) for over three decades. However, little is known about the outcomes of childhood SDR in adults.  Objectives: 1) To study the effects of childhood SDR on the quality of life and ambulatory function in adult life. 2) To determine late side effects of SDR in adults.   Methods: Adults (> 17.9 years) who underwent SDR in childhood (2 - 17.9 years) between 1987 and 2013 were surveyed in 2015. Patients completed a survey, including questions on demographic information, quality of life, health, surgical outcomes, motor function, manual ability, pain, braces/orthotics, post-SDR treatment, living situation, education level, work status, and side effects of SDR.  Results: In our study population of 294 patients (18.0 - 37.4 years), patients received SDR during the ages of 2.0 - 17.9 years and were followed up 2.2 to 28.3 years after surgery. Eighty-four percent had spastic diplegia, 12% had spastic quadriplegia, and 4% had spastic triplegia. The majority (88%) of patients reported improved post-SDR quality of life and 1% considered the surgery detrimental. Most (83%) would recommend the procedure to others and 3% would not. However, patients who would not recommend SDR to others ambulated with a walker or were not ambulatory at all prior to SDR. The majority (83%) of patients improved (30%) or remained stable (53%) in ambulation. Twenty-nine percent of patients reported pain, mostly in the back and lower limbs, with a mean pain level of 4.4 ± 2.4 on the Numeric Pain Rating Scale (NPRS). Decreased sensation in small areas of the lower limbs was reported by 8% of patients, though this did not affect daily life. Scoliosis was diagnosed in 28%, with 40% of these patients pursuing treatment. Whether scoliosis was related to SDR is not clear, though scoliosis is known to occur in patients with CP and also in the general population. Only 4% of patients underwent spinal fusion.  Orthopedic surgeries were pursued by 59% of patients. The most common orthopedic surgeries were hamstring lengthenings (31%), Achilles tendon lengthenings (18%), adductor lengthenings (16%), and derotational osteotomies (16%). Twenty-four percent of all patients later underwent hip surgery and 8% had surgeries on their knees.  Conclusion: Results of this study indicate that the beneficial effects of childhood SDR extend to adulthood quality of life and ambulatory function without late side effects of surgery

Gemini Long-slit Observations of Luminous Obscured Quasars: Further Evidence for an Upper Limit on the Size of the Narrow-Line Region

We examine the spatial extent of the narrow-line regions (NLRs) of a sample of 30 luminous obscured quasars at $0.4 < z < 0.7$ observed with spatially resolved Gemini-N GMOS long-slit spectroscopy. Using the [OIII]$\lambda5007$ emission feature, we estimate the size of the NLR using a cosmology-independent measurement: the radius where the surface brightness falls to 10$^{-15}$ erg s$^{-1}$ cm$^{-2}$ arcsec$^{-2}$. We then explore the effects of atmospheric seeing on NLR size measurements and conclude that direct measurements of the NLR size from observed profiles are too large by 0.1 - 0.2 dex on average, as compared to measurements made to best-fit S\'{e}rsic or Voigt profiles convolved with the seeing. These data, which span a full order of magnitude in IR luminosity ($\log{(L_{8 \mu \mathrm{m}} / \mathrm{erg\, s}^{-1})} = 44.4 - 45.4$) also provide strong evidence that there is a flattening of the relationship between NLR size and AGN luminosity at a seeing-corrected size of $\sim 7$ kpc. The objects in this sample have high luminosities which place them in a previously under-explored portion of the size-luminosity relationship. These results support the existence of a maximal size of the narrow-line region around luminous quasars; beyond this size either there is not enough gas, or the gas is over-ionized and does not produce enough [OIII]$\lambda5007$ emission.Comment: 10 pages, 6 figures, accepted for publication in the Astrophysical Journa

Antimicrobial and anti-inflammatory activity of chitosan-alginate nanoparticles: a targeted therapy for cutaneous pathogens.

Advances in nanotechnology have demonstrated potential application of nanoparticles (NPs) for effective and targeted drug delivery. Here we investigated the antimicrobial and immunological properties and the feasibility of using NPs to deliver antimicrobial agents to treat a cutaneous pathogen. NPs synthesized with chitosan and alginate demonstrated a direct antimicrobial activity in vitro against Propionibacterium acnes, the bacterium linked to the pathogenesis of acne. By electron microscopy (EM) imaging, chitosan-alginate NPs were found to induce the disruption of the P. acnes cell membrane, providing a mechanism for the bactericidal effect. The chitosan-alginate NPs also exhibited anti-inflammatory properties as they inhibited P. acnes-induced inflammatory cytokine production in human monocytes and keratinocytes. Furthermore, benzoyl peroxide (BP), a commonly used antiacne drug, was effectively encapsulated in the chitosan-alginate NPs and demonstrated superior antimicrobial activity against P. acnes compared with BP alone while demonstrating less toxicity to eukaryotic cells. Together, these data suggest the potential utility of topical delivery of chitosan-alginate NP-encapsulated drug therapy for the treatment of dermatologic conditions with infectious and inflammatory components

Near Infrared Spectra and Intrinsic Luminosities of Candidate Type II Quasars at 2 < z < 3.4

We present JHK near-infrared (NIR) spectroscopy of 25 candidate Type II quasars selected from the Sloan Digital Sky Survey, using Triplespec on the Apache Point Observatory 3.5m telescope, FIRE at the Magellan/Baade 6.5m telescope, and GNIRS on Gemini. At redshifts of 2 < z < 3.4, our NIR spectra probe the rest-frame optical region of these targets, which were initially selected to have strong lines of CIV and Ly alpha, with FWHM<2000 km/s from the SDSS pipeline. We use the [OIII]5007 line shape as a model for the narrow line region emission, and find that \halpha\ consistently requires a broad component with FWHMs ranging from 1000 to 7500 km/s. Interestingly, the CIV lines also require broad bases, but with considerably narrower widths of 1000 to 4500 km/s. Estimating the extinction using the Balmer decrement and also the relationship in lower-z quasars between rest equivalent width and luminosity in the [OIII] line, we find typical A_V values of 0-2 mag, which naturally explain the attenuated CIV lines relative to Halpha. We propose that our targets are moderately obscured quasars. We also describe one unusual object with three distinct velocity peaks in its [OIII] spectrum.Comment: Accepted for publication in ApJ, 18 pages, 14 figure

Zooming into local active galactic nuclei: The power of combining SDSS-IV MaNGA with higher resolution integral field unit observations

Ionised gas outflows driven by active galactic nuclei (AGN) are ubiquitous in high luminosity AGN with outflow speeds apparently correlated with the total bolometric luminosity of the AGN. This empirical relation and theoretical work suggest that in the range L_bol ~ 10^43-45 erg/s there must exist a threshold luminosity above which the AGN becomes powerful enough to launch winds that will be able to escape the galaxy potential. In this paper, we present pilot observations of two AGN in this transitional range that were taken with the Gemini North Multi-Object Spectrograph Integral Field Unit (IFU). Both sources have also previously been observed within the Sloan Digital Sky Survey-IV (SDSS) Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey. While the MaNGA IFU maps probe the gas fields on galaxy-wide scales and show that some regions are dominated by AGN ionization, the new Gemini IFU data zoom into the centre with four times better spatial resolution. In the object with the lower L_bol we find evidence of a young or stalled biconical AGN-driven outflow where none was obvious at the MaNGA resolution. In the object with the higher L_bol we trace the large-scale biconical outflow into the nuclear region and connect the outflow from small to large scales. These observations suggest that AGN luminosity and galaxy potential are crucial in shaping wind launching and propagation in low-luminosity AGN. The transition from small and young outflows to galaxy-wide feedback can only be understood by combining large-scale IFU data that trace the galaxy velocity field with higher resolution, small scale IFU maps.Comment: 14 pages, accepted for publication in MNRA