Murine model for congenital CMV infection and hearing impairment

<p>Abstract</p> <p>Background</p> <p>Congenital cytomegalovirus (CMV) infection is the leading cause of sensorineural hearing loss (SNHL), and SNHL is the most frequent sequela of congenital CMV infection. But the pathogenic mechanism remains unknown, and there is no ideal CMV intrauterine infection animal model to study the mechanisms by which SNHL develops.</p> <p>Methods</p> <p>We established the congenital murine cytomegalovirus (MCMV) infection model by directly injecting the virus into the placenta on day 12.5 of gestation. Then, we observed the development and the MCMV congenital infection rate of the fetuses on the day they were born. Furthermore, we detected the auditory functions, the conditions of the MCMV infection, and the histological change of the inner ears of 28-day-old and 70-day-old offspring.</p> <p>Results</p> <p>Both the fetal loss rate and the teratism rate of offspring whose placentas were inoculated with MCMV increased, and their body length, head circumference, and weight decreased. The hearing level of offspring both decreased at both 28- and 70-days post birth; the 70-day-old mice developed lower hearing levels than did the 28-day old mice. No significant inflammatory changes in the cochleae of the mice were observed. MCMV DNA signals were mainly detected in the spiral ganglion neurons and the endolymph area, but not in the perilymph area. The number of neurons decreased, and their ultrastructures changed. Moreover, with age, the number of neurons dramatically decreased, and the ultrastructural lesions of neurons became much more severe.</p> <p>Conclusions</p> <p>The results suggest that the direct injection of MCMV into the placenta may efficiently cause fetal infection and disturb the intrauterine development of the fetus, and placental inoculation itself has no obvious adverse effects on offspring. The reduction in the number of spiral ganglion neurons and the ultrastructural lesions of the neurons may be the major cause of congenital CMV infection-induced progressive SNHL.</p

Numerical Investigation of a Tuned Heave Plate Energy-Harvesting System of a Semi-Submersible Platform

A novel tuned heave plate energy-harvesting system (THPEH) is presented for the motion suppressing and energy harvesting of a semi-submersible platform. This THPEH system is designed based on the principle of a tuned mass damper (TMD) and is composed of spring supports, a power take-off system (PTO) and four movable heave plates. The permanent magnet linear generators (PMLG) are used as the PTO system in this design. A semi-submersible platform operating in the South China Sea is selected as the research subject for investigating the effects of the THPEH system on motion reduction and harvesting energy through numerical simulations. The numerical model of the platform and the THPEH system, which was established based on hydrodynamic analysis, is modified and validated by the results of the flume test of a 1:70 scale model. The effects of the parameters, including the size, the frequency ratio and the damping ratio of the THPEH system, are systematically investigated. The results show that this THPEH system, with proper parameters, could significantly reduce the motions of the semi-submersible platform and generate considerable power under different wave conditions

In situ synthesis of AlN particles in Mg\u2013Al alloy by Mg3N2 addition

This communication reports an experimental study on the in situ formation of hard AlN particles in an Mg\u201310 wt.% Al alloy at 700 \ub0C by externally adding Mg3N2 powders.Peer reviewed: YesNRC publication: Ye

The cascade influence of grain trade shocks on countries in the context of the Russia-Ukraine conflict

Abstract The Russia-Ukraine conflict has severely impacted global food security. This may increase the risk of supply chain disruption in low-income countries that rely heavily on grain imports. This study used production and trade data for wheat, barley and maize from 1995 to 2021 to construct longitudinal trade networks. On this basis, a cascading failure network model of shock propagation was used to identify the direct or indirect dependence of other countries on grain exported from Russia and Ukraine and the impact caused by trade shocks. The results revealed that the interruption of grain exports from Russia and Ukraine has resulted in an increasing impact on the global grain trade year by year and that the wheat trade is the most vulnerable to shock propagation, but it is also the most resilient. Russia and Ukraine interrupt exports of grain, causing more than 50% reduction in direct imports to 30 countries, including Eritrea, Seychelles, Kazakhstan and Mongolia. A shock propagation model that considers indirect dependence yields divergent results, with lower middle income (LM) countries in North Africa, Southeast Asia and West Asia facing supply shocks from reduced imports because they are unable to fully exploit the trade channels to balance grain supply and demand. Under the COVID-19 pandemic, this indirect dependence on imports is more prominent. It is worth noting that Eastern and Southern European countries often act as intermediaries to spread shocks during cascading failures. In the process of shock propagation, the main suppliers of grain include the United States, Canada, France, Argentina and Brazil. After the outbreak of COVID-19, the import demand faced by Australia increased significantly. We also examined how nodal characteristics relate to shock propagation dynamics and country vulnerability, finding that high import diversity, low import dependence and regional characteristics are effective in buffering countries from supply shocks. This study contributes to our understanding of the external supply risks for grain arising from the Russia-Ukraine conflict in a pandemic context, highlights the issue of accessibility in food security and provides trade policy recommendations to mitigate national vulnerability to food insecurity, thereby creating a resilient food trade system

An Angle-Stable Ultra-Wideband Single-Layer Frequency Selective Surface Absorber

An ultra-wideband polarization-insensitive frequency selective surface (FSS) absorber is proposed for S to K-band applications. The absorber comprises two compensation slabs, a lossy FSS layer and a grounded dielectric plate. The FSS unit cell is a combination of a second-order Chinese knot and a cross. To enhance the bandwidth and angular stability of the single-layer FSS absorber, a compensation layer composed of FR4 and polymethyl methacrylate (PMMA) slabs is incorporated. The proposed FSS absorber demonstrates a remarkable absorption rate of over 90% within the frequency range of 3.1–22.1 GHz, exhibiting a fractional bandwidth of 150.8%. Even when subjected to an oblique incidence of 45°, the absorber maintains an 80% absorption rate in the frequency range of 4.4–19.1 GHz for both TE and TM polarizations. The total thickness of the FSS absorber is 0.0848 λL (the wavelength at the lowest cutoff frequency), and only 1.08 times the Rozanov limit. To validate the design, a prototype of the proposed absorber was fabricated and measured. Good agreements were observed between the simulations and measurements

Stock market liberalization, foreign institutional investors, and informational efficiency of stock prices

This study investigates the effects of investments by qualified foreign institutional investors (QFIIs) on the informational efficiency of stock prices in Chinese A‐share stock markets. Employing a large sample of listed firms from 2004 to 2012, we document a significant and positive relationship between stock price informativeness and stock ownership by foreign institutional investors. We also use the instrument‐variable approach, propensity‐score matching method, as well as an alternative measure of informational efficiency to ensure the robustness of our findings. We document that the effects of foreign ownership on informational efficiency is stronger for firms with lower levels of assets intangibility and in regions with less developed institutions. In addition, we document that the effects of foreign ownership on informational efficiency is more pronounced when QFIIs have better local information and more incentives to monitor.Peer reviewe

Water-Weakening Effects on the Mechanical Behavior of Different Rock Types: Phenomena and Mechanisms

The presence of water strongly affects rock properties and would be related to a series of geological disasters. To understand water saturation effects on the mechanical behavior of different rock types and interpret the underlying mechanisms of differences in water sensitivity, three kinds of rocks, namely sandstone, granite and marble, were selected for tests. Uniaxial compression experiments were conducted on specimens under oven-dried and water-saturated conditions. Acoustic emission (AE) techniques were also applied to monitor and record AE signals during tests. Experimental results reveal that water weakens the mechanical parameters of the three tested rocks, such as uniaxial compressive strength (UCS), elastic modulus and critical strain. The sandstone undergoes the greatest weakening with the addition of pore water, the mechanical properties of the granite exhibit relatively minor reductions, while the marble is the least affected by water saturation. The water-weakening degree of rock properties depends on the porosity as well as the mineralogy, especially the proportion of quartz and swelling clays. Moreover, after water saturation, the failure pattern of the sandstone and the granite tends to transform into the shear-dominant mode from the tensile one in dry state, probably due to frictional reduction. However, the water presence does not change the failure mode of the marble