International study of factors affecting human chromosome translocations

Chromosome translocations in peripheral blood lymphocytes of normal, healthy humans increase with age, but the effects of gender, race, and cigarette smoking on background translocation yields have not been examined systematically. Further, the shape of the relationship between age and translocation frequency (TF) has not been definitively determined. We collected existing data from 16 laboratories in North America, Europe, and Asia on TFs measured in peripheral blood lymphocytes by fluorescence in situ hybridization whole chromosome painting among 1933 individuals. In Poisson regression models, age, ranging from newborns (cord blood) to 85 years, was strongly associated with TF and this relationship showed significant upward curvature at older ages versus a linear relationship (p < 0.001). Ever smokers had significantly higher TFs than non-smokers (rate ratio (RR) = 1.19, 95% confidence interval (CI), 1.09-1.30) and smoking modified the effect of age on TFs with a steeper age-related increase among ever smokers compared to non-smokers (p < 0.001). TFs did not differ by gender. Interpreting an independent effect of race was difficult owing to laboratory variation. Our study is three times larger than any pooled effort to date, confirming a suspected curvilinear relationship of TF with age. The significant effect of cigarette smoking has not been observed with previous pooled studies of TF in humans. Our data provide stable estimates of background TF by age, gender, race, and smoking status and suggest an acceleration of chromosome damage above age 60 and among those with a history of smoking cigarettes. © 2008 Elsevier B.V. All rights reserved

The Impact of Imports and Exports in a Country’s Quality of Life

This paper is a sequel to Sirgy et al. (Social Ind. Res. 68(3) (2004) 251), “The Impact of Globalization on a Country’s Quality of Life: Toward an Integrated Model” published in Social Indicators Research. That paper conceptualized globalization in terms of the free flow of four major components: (1) goods and services, (2) people, (3) capital, and (4) information. The current paper focuses on the free flow of goods and services, one of the four major components of globalization. Specifically, we (1) articulate the trade globalization construct, (2) show the complex mediating effects between trade globalization and QOL, and (3) describe under what conditions these positive vs. negative QOL effects are likely to occur. We develop a set of theoretical propositions to capture these mediating and moderating effects. Based on the theoretical model, we suggest the following public policy recommendations: (1) Encourage exporting firms not to outsource jobs. (2) Encourage firms to export more products in ways that can enhance their production efficiency. (3) Discourage firms from exporting culturally sensitive (and possibly offensive) products to culturally distant countries. (4) Encourage firms to export more products with potential for technology transfer. (5) Encourage firms in industries with a significant comparative advantage to increase exports. (6) Encourage imports of products that do not compete with high employment domestic industries where workers cannot easily transition to more productive employment. (7) Impose trade barriers as short-term solution to help?threatened industries while helping those industries retool to become more competitive. (8)?Assist displaced workers by re-training them to shift to industries with comparative advantage