Letter from J[ohn] Wesley Little to John Muir, 1913 Feb 25 .

Picture Rocks, Pa. Feb 25 1913My dear John MuirThis little letter from an eleven year old school girl written on her own impulse explains itself. If you feel like putting your autograph on the enclosed sheet I am quite sure it would be an incentive for her to continue her interest in John Muir and his Sierras. She does not know I am actually taking the liberty to mail this to you so she will not be disappointed if the autograph does not appear but I know she will be overjoyed if it doesVery sincerely and respectfully J Wesley Little05383 Picture Rocks, Pa.Feb 27, 1913Dear Mr Muir:I have heard and read about you. And would like to know you. So would my father J. Wesley Little. He is an artist. He said he would rather take a walk with you than any other person in the world. I live in a beautiful little town that lies between three beautiful hills One looks like the work of a glacier Father found a rock there that was made up of a different kind of stone than what is around here and fossils. I would like to live in the Sierra Nevada mountains among the birds, animals, flowers and trees although I love my home.Yours trulyEleanor R. Little0538

Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials

An amendment to this paper has been published and can be accessed via the original article

Letter from J[ohn] Wesley Little to John Muir, 1913 Feb 25 .

Picture Rocks, Pa. Feb 25 1913My dear John MuirThis little letter from an eleven year old school girl written on her own impulse explains itself. If you feel like putting your autograph on the enclosed sheet I am quite sure it would be an incentive for her to continue her interest in John Muir and his Sierras. She does not know I am actually taking the liberty to mail this to you so she will not be disappointed if the autograph does not appear but I know she will be overjoyed if it doesVery sincerely and respectfully J Wesley Little05383 Picture Rocks, Pa.Feb 27, 1913Dear Mr Muir:I have heard and read about you. And would like to know you. So would my father J. Wesley Little. He is an artist. He said he would rather take a walk with you than any other person in the world. I live in a beautiful little town that lies between three beautiful hills One looks like the work of a glacier Father found a rock there that was made up of a different kind of stone than what is around here and fossils. I would like to live in the Sierra Nevada mountains among the birds, animals, flowers and trees although I love my home.Yours trulyEleanor R. Little0538

Evaluation of benazepril in cats with heart disease in a prospective, randomized, blinded, placebo‐controlled clinical trial

International audienceBackground:Heart disease is an important cause of morbidity and mortality in cats,but there is limited evidence of the benefit of any medication. Hypothesis:The angiotensin-converting enzyme inhibitor benazepril would delaythe time to treatment failure in cats with heart disease of various etiologies. Animals:One hundred fifty-one client-owned cats. Methods:Cats with heart disease, confirmed by echocardiography, with or withoutclinical signs of congestive heart failure, were recruited between 2002 and 2005and randomized to benazepril or placebo in a prospective, multicenter, parallel-group, blinded clinical trial. Benazepril (0.5-1.0 mg/kg) or placebo was administeredPO once daily for up to 2 years. The primary endpoint was treatment failure. Ana-lyses were conducted separately for all-cause treatment failure (main analysis) andheart disease-related treatment failure (supportive analysis). Results:No benefit of benazepril versus placebo was detected for time to all-causetreatment failure (P= .42) or time to treatment failure related to heart disease(P= .21). Hazard ratios (95% confidence interval [CI]) from multivariate analysis forbenazepril compared with placebo were 1.00 (0.57-1.74) for all-cause failure, and0.99 (0.50-1.94) for forward selection and 0.93 (0.48-1.81) for bidirectional selec-tion models for heart disease-related failure. There were no significant differencesbetween groups over time after administration of the test articles in left atriumdiameter, left ventricle wall thickness, quality of life scores, adverse events, orplasma biochemistry or hematology variables. Conclusions and Clinical Relevance:Benazepril was tolerated well in cats withheart disease, but no evidence of benefit was detecte