Uso de medios de comunicación digital y rendimiento académico en estudiantes del colegio "Huellas School”, en Chimbote 2022

En los últimos años los métodos de enseñanza han cambiado en los centros educativos, por el cual los medios de comunicación digital llegaron a influir de manera directa en los estudiantes. Por ello, se consideró como objetivo analizar el uso de medios de comunicación digital y rendimiento académico en la educación básica de estudiantes del colegio Huellas School, en Chimbote 2022. Asimismo, se utilizó como instrumento la encuesta, mediante la cual nos permitirá recolectar datos cuantitativos sobre las variables del estudio. De tal manera la encuesta contiene 18 preguntas. El método de diseño es básico y de tipo correlacional, desde un enfoque cuantitativo para la recolección de datos, demostrando una hipótesis planteada en base a la medición numérica y el análisis estadístico. Por lo tanto, si existe una relación entre ambas variables. La correlación de Pearson arrojó 0.370 demostrando que existe correlación positiva moderada. Por ello se observa que el 64% de los estudiantes del colegio Huellas School mencionó que el nivel de entretenimiento es bueno. Se concluye que se analizó el uso de medios de comunicación digital y rendimiento académico, demostrando que existe una relación entre ambas variables. Por todo ello, se ha demostrado que existe la correlación positiva

La aplicación de la gestión administrativa incide en las finanzas corporativas de Chancadora Excalibur SAC año 2020

La presente tesis titulada La Aplicación de la Gestión Administrativa incide en las Finanzas Corporativas de Chancadora Excalibur SAC año 2020. Para optar el título profesional en Contabilidad y Finanzas. El objetivo es determinar como la aplicación de la Gestión Administrativa incide en las finanzas corporativas de la empresa Chancadora Excalibur SAC en el año 2020. En el estudio se utilizó la investigación descriptiva aplicada porque no se modifican y el estudio se realiza de manera objetiva sobre las variables planeadas. El tipo de diseño de la investigación es no Experimental de corte transversal. Este trabajo se justifica en que ayudará a la empresa en sus problemas de gestión administrativa que le permitirá tomar decisiones adecuadas y saber las distintas fuentes o maneras de financiamiento para lograr ampliar y mejorar la Rentabilidad de empresa. Para esta investigación la técnica utilizada fue la encuesta y el instrumento de recolección de datos fue el cuestionario, la población corresponde a 20 trabajadores. Se llegó a la siguiente conclusión de que existe correlación entre la aplicación de la gestión administrativa y su incidencia en las finanzas corporativas de la empresa Chancadora Excalibur S.A.C, dado que la gestión administrativa ayudará con sus procesos a que mejoren las diferentes actividades internas, no solo en el área de finanzas sino también en las diferentes áreas, creando un ambiente laboral óptimo para el beneficio económico de la empresa por lo que se recomienda tener en cuenta evaluar y establecer el flujo de caja con el debido procedimiento, teniendo en cuenta los ingresos, egresos y la empresa, que le permita tomar decisiones adecuadas y a tiempo, para una obtención mayor de rentabilidad, y cumplimento deobligaciones con terceros.This thesis entitled The Application of Administrative Management affects the Corporate Finance ofChancadora Excalibur SAC year 2020. To opt for the professionaldegree in Accounting and Finance. The objective is to determine how the application of Administrative Management affects the corporate finances of the company Chancadora Excalibur SAC in 2020. In the study, applied descriptive research was used because they are not modified and the study is carried out objectively on the planned variables. The type of research design is non-Experimental crosssectional. This work is justified in that it will help the company in its administrative management problems that will allow it to make appropriate decisions and know the different sources or ways of financing to expand and improve the profitability of the company. For this research, the technique used was the survey and the data collection instrument was the questionnaire, the population corresponds to 20 workers. The following conclusion was reached that there is a correlation between the application of administrative management and its impact on the corporate finances of the company Chancadora Excalibur SAC, since administrative manageme nt will help with its processes to improve the different internal activities, not only in the finance area but also in the different areas, creating an optimal work environment for the economic benefit of the company, so it is recommended to consider evaluating and establishing the cash flow with due procedure, taking into account the income, expenses and the company, which allows you to make appropriate decisions on time, to obtain greater profitability, and fulfill obligations with third parties

Detection of collagen triple helix repeat containing-1 and nuclear factor (erythroid-derived 2)-like 3 in colorectal cancer

<p>Abstract</p> <p>Background</p> <p>Collagen Triple Helix Repeat Containing-1 (CTHRC1) and Nuclear factor (erythroid-derived 2)-like 3 (NFE2L3) may be useful biomarker candidates for the diagnosis of colorectal cancer (CRC) since they have shown an increase messenger RNA transcripts (mRNA) expression level in adenomas and colorectal tumours when compared to normal tissues.</p> <p>Methods</p> <p>To evaluate CTHRC1 and NFE2L3 as cancer biomarkers, it was generated and characterised several novel specific polyclonal antibodies (PAb), monoclonal antibodies (MAbs) and soluble Fab fragments (sFabs) against recombinant CTHRC1 and NFE2L3 proteins, which were obtained from different sources, including a human antibody library and immunised animals. The antibodies and Fab fragments were tested for recognition of native CTHRC1 and NFE2L3 proteins by immunoblotting analysis and enzyme-linked immunosorbent assay (ELISA) in colorectal cell lines derived from tumour and cancer tissues.</p> <p>Results</p> <p>Both, antibodies and a Fab fragment showed high specificity since they recognised only their corresponding recombinant antigens, but not a panel of different unrelated- and related proteins.</p> <p>In Western blot analysis of CTHRC1, a monoclonal antibody designated CH21D7 was able to detect a band of the apparent molecular weight of a full-length CTHRC1 in the human colon adenocarcinoma cell line HT29. This result was confirmed by a double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) with the monoclonal antibodies CH21D7 and CH24G2, detecting CTHRC1 in HT29 and in the colon adenocarcinoma cell line SW620.</p> <p>Similar experiments were performed with PAb, MAbs, and sFab against NFE2L3. The immunoblot analysis showed that the monoclonal antibody 41HF8 recognised NFE2L3 in HT29, and leukocytes. These results were verified by DAS-ELISA assay using the pairs PAb/sFab E5 and MAb 41HF8/sFab E5.</p> <p>Furthermore, an immunoassay for simultaneous detection of the two cancer biomarkers was developed using a Dissociation-Enhanced Lanthanide Fluorescent Immunoassay technology (DELFIA).</p> <p>Conclusions</p> <p>In conclusion, the antibodies obtained in this study are specific for CTHRC1 and NFE2L3 since they do not cross-react with unrelated- and related proteins and are useful for specific measurement of native CTHRC1 and NFE2L3 proteins. The antibodies and immunoassays may be useful for the analysis of CTHRC1 and NFE2L3 in clinical samples and for screening of therapeutic compounds in CRC.</p

Development of biological tools to assess the role of TMPRSS4 and identification of novel tumor types with high expression of this prometastatic protein

Metastatic spread is responsible for the majority of cancer deaths and identification of metastasisrelated therapeutic targets is compulsory. TMPRSS4 is a pro-metastatic druggable transmembrane type II serine protease whose expression has been associated with the development of several cancer types and poor prognosis. To study the role and expression of this protease in cancer, we have developed molecular tools (active recombinant proteins and a polyclonal antibody) that can be used for diagnostic purposes and for testing anti-TMPRSS4 drugs. In addition, we have evaluated TMPRSS4 protein expression in several cancer tissue microarrays (TMAs). Full length and truncated TMPRSS4 recombinant proteins maintained the catalytic activity in two different expression systems (baculovirus and E. coli). Sensitivity of the rabbit polyclonal antisera against TMPRSS4 (ING-pAb) outperformed the antibody most commonly used in clinical settings. Analysis by immunohistochemistry in the different TMAs identified a subset of adenocarcinomas, squamous carcinomas, large cell carcinomas and carcinoids of the lung, in which TMPRSS4 expression may define aggressive tumors. In conclusion, our biological tools will help the characterization of TMPRSS4 activity and protein expression, as well as the evaluation of anti-TMPRSS4 drugs. Future studies should determine the clinical value of assessing TMPRSS4 levels in different types of lung cancer

Single-centre study of 628 adult, primary kidney transplant recipients showing no unfavourable effect of new-onset diabetes after transplant

To better understand the implications of new-onset diabetes after transplant (NODAT), we used our prospectively followed cohort of 628 adult primary kidney transplant recipients to determine the prognostic impact of pretransplant diabetes and NODAT.The study cohort consisted of all participants in four randomised immunosuppression trials performed at our centre since May 2000. For each cause-specific hazard analysed, Cox stepwise regression was used to determine a multivariable model of significant baseline predictors; the multivariable influence of having pretransplant diabetes and NODAT (t) (the latter defined as a zero-one, time-dependent covariate) was subsequently tested. Similar analyses of estimated glomerular filtration rate (eGFR) at 36 and 60 months post transplant were performed using stepwise linear regression. Finally, a repeated measures analysis of mean HbA1c as a function of diabetes category (pretransplant diabetes vs NODAT) and randomised trial (first to fourth) was performed.Median follow-up was 56 months post transplant. Patients with pretransplant diabetes comprised 23.4% (147/628), and 22.5% (108/481) of the remaining patients developed NODAT. Pretransplant diabetes had no prognostic influence on first biopsy-proven acute rejection and death-censored graft failure hazard rates, nor on eGFR, but was associated with significantly higher rates of death with a functioning graft (DWFG) (p = 0.003), DWFG due to a cardiovascular event (p = 0.005) and infection that required hospitalisation (p = 0.03). NODAT (t) had no unfavourable impact on any of these hazard rates nor on eGFR, with actuarial freedom from DWFG remaining at over 90% among patients in pre- and post-NODAT states at 72 months post transplant/NODAT. Mean HbA1c for patients in the first to fourth randomised trials, averaged across diabetes category, decreased by trial (7.28%, 6.92%, 6.87% and 6.64% [56.1, 52.1, 51.6 and 49.1 mmol/mol], respectively; p = 0.02).Less-than-expected post-NODAT risk for graft loss and death may exist in the current climate of tighter glucose monitoring post transplant

Multivariable risk of developing new onset diabetes after transplant—results from a single‐center study of 481 adult, primary kidney transplant recipients

Background Understanding the relative contributions of baseline demographics and immunosuppressive therapy on NODAT risk may help in developing preventive strategies. Methods Using our prospectively followed cohort of 481 adult, primary kidney transplant recipients without pre‐transplant diabetes, we determined the significant baseline predictors for the hazard rate of developing NODAT via Cox stepwise regression. The multivariable influence of first BPAR (defined as a time‐dependent covariate) was also tested. Results Median follow‐up was 57 mo post‐transplant; the overall percentage who developed NODAT was 22.5% (108/481). Four baseline predictors of a greater NODAT hazard rate were found (by order of selection): higher BMI (p < 0.000001), planned maintenance with SRL (p = 0.0003), non‐white recipient (p = 0.0004), and older recipient age (p = 0.0004). Approximately one‐half of the 106 patients in the highest demographic risk category (BMI ≥25 kg/m2, non‐white race, and age at transplant ≥40 yr) developed NODAT; actuarial NODAT risk ranged from 10% to 30% in the lower demographic risk categories. First BPAR was also associated with significantly higher NODAT in multivariable analysis (p = 0.02)—the highly elevated NODAT rate observed during the first few months post‐transplant and following first BPAR appears to demonstrate the diabetogenic effect of using high‐dose (intravenous) corticosteroids. Conclusions The disturbingly high NODAT rate found among patients having multiple demographic risk factors is still an important problem that awaits a better solution

\u3ci\u3eDrosophila\u3c/i\u3e Muller F Elements Maintain a Distinct Set of Genomic Properties Over 40 Million Years of Evolution

The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D. erecta, D. mojavensis, and D. grimshawi F elements and euchromatic domains from the Muller D element. We find that F elements have greater transposon density (25–50%) than euchromatic reference regions (3–11%). Among the F elements, D. grimshawi has the lowest transposon density (particularly DINE-1: 2% vs. 11–27%). F element genes have larger coding spans, more coding exons, larger introns, and lower codon bias. Comparison of the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation. F element genes have lower estimated DNA melting temperatures than D element genes, potentially facilitating transcription through heterochromatin. Most F element genes (~90%) have remained on that element, but the F element has smaller syntenic blocks than genome averages (3.4–3.6 vs. 8.4–8.8 genes per block), indicating greater rates of inversion despite lower rates of recombination. Overall, the F element has maintained characteristics that are distinct from other autosomes in the Drosophila lineage, illuminating the constraints imposed by a heterochromatic milieu