43 research outputs found
GALEX Observations of CS and OH Emission in Comet 9P/Tempel 1 During Deep Impact
GALEX observations of comet 9P/Tempel 1 using the near ultraviolet (NUV)
objective grism were made before, during and after the Deep Impact event that
occurred on 2005 July 4 at 05:52:03 UT when a 370 kg NASA spacecraft was
maneuvered into the path of the comet. The NUV channel provides usable spectral
information in a bandpass covering 2000 - 3400 A with a point source spectral
resolving power of approximately 100. The primary spectral features in this
range include solar continuum scattered from cometary dust and emissions from
OH and CS molecular bands centered near 3085 and 2575 A, respectively. In
particular, we report the only cometary CS emission detected during this event.
The observations allow the evolution of these spectral features to be tracked
over the period of the encounter. In general, the NUV emissions observed from
Tempel 1 are much fainter than those that have been observed by GALEX from
other comets. However, it is possible to derive production rates for the parent
molecules of the species detected by GALEX in Tempel 1 and to determine the
number of these molecules liberated by the impact. The derived quiescent
production rates are Q(H2O) = 6.4e27 molecules/s and Q(CS2) = 6.7e24
molecules/s, while the impact produced an additional 1.6e32 H2O molecules and
1.3e29 CS2 molecules, a similar ratio as in quiescent outgassing.Comment: 15 pages, 4 figures, accepted for publication in the Astrophysical
Journa
Understanding the association between skin involvement and joint activity in patients with psoriatic arthritis: experience from the Corrona Registry.
Objective: To compare the characteristics of patients with psoriatic arthritis among patient groups stratified by degree of skin and joint involvement, and to evaluate the relationship between skin severity and joint activity.
Methods: Body surface area (BSA) and Clinical Disease Activity Index (CDAI) at enrolment were analysed. Patient characteristics were stratified by skin severity and joint activity. Baseline patient characteristics, clinical and disease characteristics and patient-reported outcomes were compared. The strength of the relationship of skin severity and joint activity was evaluated using methods for categorical variables (χ
Results: 1542 adult patients in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry enrolled between 21 May 2013 and 20 September 2016 were analysed. Most patients in the BSA \u3e3%/CDAI moderate/high subgroup had worse clinical and patient-reported outcomes. A significant (p
Conclusion: Skin severity is modestly correlated with joint activity, and patients with higher skin severity are two times more likely to have increased joint involvement. Clinicians need to address both skin severity and joint activity in treatment decisions
Preliminary Results on HAT-P-4, TrES-3, XO-2, and GJ 436 from the NASA EPOXI Mission
EPOXI (EPOCh + DIXI) is a NASA Discovery Program Mission of Opportunity using
the Deep Impact flyby spacecraft. The EPOCh (Extrasolar Planet Observation and
Characterization) Science Investigation will gather photometric time series of
known transiting exoplanet systems from January through August 2008. Here we
describe the steps in the photometric extraction of the time series and present
preliminary results of the first four EPOCh targets.Comment: 4 pages, 2 figures. To appear in the Proceedings of the 253rd IAU
Symposium: "Transiting Planets", May 2008, Cambridge, M
Precise Chemical Analyses of Planetary Surfaces
We identify the chemical elements and element ratios that should be analyzed to address many of the issues identified by the Committee on Planetary and Lunar Exploration (COMPLEX). We determined that most of these issues require two sensitive instruments to analyze the necessary complement of elements. In addition, it is useful in many cases to use one instrument to analyze the outermost planetary surface (e.g. to determine weathering effects), while a second is used to analyze a subsurface volume of material (e.g., to determine the composition of unaltered planetary surface material). This dual approach to chemical analyses will also facilitate the calibration of orbital and/or Earth-based spectral observations of the planetary body. We determined that in many cases the scientific issues defined by COMPLEX can only be fully addressed with combined packages of instruments that would supplement the chemical data with mineralogic or visual information
Observational and Dynamical Characterization of Main-Belt Comet P/2010 R2 (La Sagra)
We present observations of comet-like main-belt object P/2010 R2 (La Sagra)
obtained by Pan-STARRS 1 and the Faulkes Telescope-North on Haleakala in
Hawaii, the University of Hawaii 2.2 m, Gemini-North, and Keck I telescopes on
Mauna Kea, the Danish 1.54 m telescope at La Silla, and the Isaac Newton
Telescope on La Palma. An antisolar dust tail is observed from August 2010
through February 2011, while a dust trail aligned with the object's orbit plane
is also observed from December 2010 through August 2011. Assuming typical phase
darkening behavior, P/La Sagra is seen to increase in brightness by >1 mag
between August 2010 and December 2010, suggesting that dust production is
ongoing over this period. These results strongly suggest that the observed
activity is cometary in nature (i.e., driven by the sublimation of volatile
material), and that P/La Sagra is therefore the most recent main-belt comet to
be discovered. We find an approximate absolute magnitude for the nucleus of
H_R=17.9+/-0.2 mag, corresponding to a nucleus radius of ~0.7 km, assuming an
albedo of p=0.05. Using optical spectroscopy, we find no evidence of
sublimation products (i.e., gas emission), finding an upper limit CN production
rate of Q_CN<6x10^23 mol/s, from which we infer an H2O production rate of
Q_H2O<10^26 mol/s. Numerical simulations indicate that P/La Sagra is
dynamically stable for >100 Myr, suggesting that it is likely native to its
current location and that its composition is likely representative of other
objects in the same region of the main belt, though the relatively close
proximity of the 13:6 mean-motion resonance with Jupiter and the (3,-2,-1)
three-body mean-motion resonance with Jupiter and Saturn mean that dynamical
instability on larger timescales cannot be ruled out.Comment: 23 pages, 13 figures, accepted for publication in A
Association of the clinical components in the distal interphalangeal joint synovio-entheseal complex and subsequent response to ixekizumab or adalimumab in psoriatic arthritis.
Objectives:
To assess the frequency of simultaneous distal interphalangeal (DIP) joint disease and adjacent nail psoriasis (finger unit) among patients with psoriatic arthritis (PsA) and compare the efficacy of the IL-17A antagonist ixekizumab (IXE) and the TNF-α inhibitor adalimumab (ADA).
Methods:
This post hoc analysis evaluated the simultaneous occurrence of DIP joint involvement (tenderness and/or swelling) and adjacent nail psoriasis among patients with PsA from the SPIRIT-H2H (NCT03151551) trial comparing IXE to ADA. Among patients with simultaneous DIP joint involvement and adjacent nail psoriasis in ≥1 digit at baseline, treatment effects were assessed through week 52 for each affected finger unit; ‘finger unit’ defines the connected DIP joint and adjacent nail of an individual digit.
Results:
A total of 354 patients had simultaneous DIP joint involvement and adjacent nail psoriasis in ≥1 finger unit at baseline. Among them, 1309 (IXE: 639; ADA: 670) finger units had baseline DIP joint tenderness and/or swelling and adjacent nail psoriasis. Proportions of affected finger units achieving complete resolution were significantly higher with IXE vs ADA as early as week 12 (38.8% vs 28.4%, P < 0.0001) and at all post-baseline assessments through week 52 (64.9% vs 57.5%, P = 0.0055).
Conclusion:
In this study cohort, patients with DIP joint involvement almost always had adjacent nail psoriasis. Greater resolution of DIP joint tenderness, swelling and adjacent nail psoriasis was achieved at all time points over 52 weeks through targeting IL-17A with IXE than TNF-α with ADA, which is noteworthy given prior comparable musculoskeletal outcomes for both drug classes
Synergies between interstellar dust and heliospheric science with an Interstellar Probe
We discuss the synergies between heliospheric and dust science, the open
science questions, the technological endeavors and programmatic aspects that
are important to maintain or develop in the decade to come. In particular, we
illustrate how we can use interstellar dust in the solar system as a tracer for
the (dynamic) heliosphere properties, and emphasize the fairly unexplored, but
potentially important science question of the role of cosmic dust in
heliospheric and astrospheric physics. We show that an Interstellar Probe
mission with a dedicated dust suite would bring unprecedented advances to
interstellar dust research, and can also contribute-through measuring dust - to
heliospheric science. This can, in particular, be done well if we work in
synergy with other missions inside the solar system, thereby using multiple
vantage points in space to measure the dust as it `rolls' into the heliosphere.
Such synergies between missions inside the solar system and far out are crucial
for disentangling the spatially and temporally varying dust flow. Finally, we
highlight the relevant instrumentation and its suitability for contributing to
finding answers to the research questions.Comment: 18 pages, 7 Figures, 5 Tables. Originally submitted as white paper
for the National Academies Decadal Survey for Solar and Space Physics
2024-203