Use of autoleukocyte, labelled with 99mTc-exametazine for evaluation of inglammatory changes in myocardium

Our purpose was to study the possibilities of autoleukocyte, labelled in vitro with 99mTc-exametazine (99m Tc-HMPAO), in evaluation of inflammatory changes of myocardium at patients with persistent form of atrial fibrillation (AF).We examined 30 patients with idiopathic persistent form of AF. For identification of the inflammatory areas in a myocardium before ablation scintigraphy (SPECT) 99mTc-HMPAO – leucocytes was carried out. Upon completion of scanning a perfusion scintigraphy of a myocardium with a 99mTc-methoxyisobutyl isonitrile (99mTc-MIBI) («Tehnetril» 99mTc, JSC Diamed, Russia) in rest under the standard protocol was carried out. Pathologic accumulation of 99mTc-HMPAO-leukocytes in a myocardium was revealed at 6 (20%) of the examined patients. Sensitivity of SPECT with 99mTc-HMPAO-leukocytes in diagnostics of inflammatory changes of a myocardium, according to our data, was - 80%, specificity - 92%, diagnostic accuracy - 90%

Use of autoleukocyte, labelled with 99mTc-exametazine for evaluation of inglammatory changes in myocardium

Our purpose was to study the possibilities of autoleukocyte, labelled in vitro with 99mTc-exametazine (99m Tc-HMPAO), in evaluation of inflammatory changes of myocardium at patients with persistent form of atrial fibrillation (AF).We examined 30 patients with idiopathic persistent form of AF. For identification of the inflammatory areas in a myocardium before ablation scintigraphy (SPECT) 99mTc-HMPAO – leucocytes was carried out. Upon completion of scanning a perfusion scintigraphy of a myocardium with a 99mTc-methoxyisobutyl isonitrile (99mTc-MIBI) («Tehnetril» 99mTc, JSC Diamed, Russia) in rest under the standard protocol was carried out. Pathologic accumulation of 99mTc-HMPAO-leukocytes in a myocardium was revealed at 6 (20%) of the examined patients. Sensitivity of SPECT with 99mTc-HMPAO-leukocytes in diagnostics of inflammatory changes of a myocardium, according to our data, was - 80%, specificity - 92%, diagnostic accuracy - 90%