Neoadjuvant use of Imiquimod Before Surgery in Extramammary Paget’s Disease

A doença de Paget extramamária (DPEM) é uma neoplasia maligna cutânea, rara, observada principalmente em mulheres caucasianas pós-menopausa. A cirurgia é o tratamento mais comum. No entanto, no que diz respeito à DPEM vulvar, o seu tratamento cirúrgico passa frequentemente por cirurgia radical, que pode ser mutilante e levar à perda de feminilidade. Recentes avanços terapêuticos têm incluído abordagem médica e multimodal médico-cirúrgico, permitindo uma maior preservação da anatomia genital e subsequente diminuição da morbilidade. Neste sentido, imiquimod tem sido utilizado, off-label, como monoterapia ou terapêutica adjuvante na DPEM.Relatamos o caso de uma mulher com DPEM extenso na área anogenital submetida a resseção cirúrgica complementada com reconstrução plástica e precedida de tratamento médico com imiquimod. O imiquimod neoadjuvante permitiu uma citorredução significativa da área tumoral, minimizando a radicalidade cirúrgica, mantendo a função local e a morfologia.Extramammary Paget's disease (EMPD) is a distinct form of a rare malignant skin neoplasm, primarily seen in postmenopausal Caucasian women. Surgery is the most common treatment. However, concerning vulvar EMPD, radical surgery can be mutilating and leads to loss of femininity. Recent therapeutic development has included medical and medical-surgical approaches, allowing better preservation of genital anatomy with subsequent reduced morbidity. Accordingly, off-label use of imiquimod has been reported as a monotherapy or adjuvant therapy in EMPD.We report the case of a woman with extensive EMPD in the anogenital area, submitted to surgical resection complemented with plastic reconstruction and preceded by imiquimod medical treatment. Neoadjuvant imiquimod induced a significant cytoreduction of the tumor area, minimizing surgical radicality and maintaining local function and morpholog

GeoPAC: Sistema de Monitoramento de Obras do PAC.

O objetivo deste documento é descrever o sistema GeoPAC. São apresentados seu histórico de desenvolvimento, sua arquitetura de software, suas principais funcionalidades e alguns exemplos de análises de contexto territorial elaboradas pela Embrapa, a partir dos dados espaciais dos empreendimentos do PAC catalogados pelo sistema. O GeoPAC está disponível remotamente para o Ministério do Planejamento, Orçamento e Gestão (MPOG) e é fornece diversos parâmetros e indicadores utilizados no acompanhamento territorial dos empreendimentos do PAC.bitstream/item/98227/1/20140225-GeoPAC2.pd

Bound state solutions of the Dirac-Rosen-Morse potential with spin and pseudospin symmetry

The energy spectra and the corresponding two- component spinor wavefunctions of the Dirac equation for the Rosen-Morse potential with spin and pseudospin symmetry are obtained. The $s-$wave ($\kappa = 0$ state) solutions for this problem are obtained by using the basic concept of the supersymmetric quantum mechanics approach and function analysis (standard approach) in the calculations. Under the spin symmetry and pseudospin symmetry, the energy equation and the corresponding two-component spinor wavefunctions for this potential and other special types of this potential are obtained. Extension of this result to $\kappa \neq 0$ state is suggested.Comment: 18 page

Intensity-duration-frequency of maximum rainfall in Mato Grosso State.

EN-US: Intensive rainfall is an important meteorological variable that is of technical interest in hydraulic projects. This study therefore generated Intensity-Duration-Frequency equations (IDF) for 14 weather stations in Mato Grosso State, based on pluviograph analysis. Annual maximum rainfall data regarding 10-to-1440-minute long rainfall events were collected from digitized daily pluviographs. Data adherence to the generalized extreme value distribution (GEV) was checked through the Kolmogorov-Smirnov test at a 20% significance level. Next, the maximum probable rainfall for return periods such as 2, 5, 10, 20, 30, 50 and 100 years was calculated and the IDF equations were adjusted. The performance of the IDF equations was evaluated based on mean absolute error (MAE), root mean square error (RMSE), bias, Willmott's concordance index and Nash-Sutcliffe efficiency index (ENS). Adjusting the IDF equations was only possible for rainfall durations ranging from 10 to 360 min at each station due to the low frequency of longer rainfalls. High variation was present in parameters of the IDF equation and in maximum rainfall intensity between stations. The satisfactory performance of the models, as attested to by statistical indices, allows using IDF equations adjusted for rainfall durations from 10 to 360 min, and return periods from 2 to 100 years, in the regions of the Mato Grosso weather stations. | PT-BR: A chuva intensa é uma importante variável meteorológica que apresenta interesse técnico em projetos hidráulicos. Assim, este estudo teve como objetivo obter equações intensidade-duração-frequência (IDF), obtidas por análise de pluviógrafos, para 14 estações no Estado do Mato Grosso. As séries anuais de intensidade máximas de chuva com duração de 10 a 1440 min foram obtidas de Pluviogramas diários digitalizados. Verificada a aderência das séries à distribuição generalizada de valores extremos, pelo teste de Kolmogorov-Smirnov à 20% de significância, calculou-se as chuvas máximas prováveis para os tempos de retorno de 2, 5, 10, 20, 30, 50 e 100 anos e, ajustaram-se as equações IDF. O desempenho das equações IDF foi avaliado pelo erro absoluto médio (MAE), erro quadrático médio (RMSE), bias, índice de concordância de Willmott e índice de eficiência de Nash-Sutcliffe (ENS). Em todas as estações foi possível ajustar apenas equações IDF para chuvas com duração de 10 a 360 min, devido à baixa frequência de chuvas com duração superior. Houve grande variação na intensidade máxima da chuva e dos parâmetros da equação IDF entre as estações estudadas. O bom desempenho dos modelos, conforme atestados por índices estatísticos, permitem a utilização das equações IDF para as durações de 10 a 360 min e tempo de retorno de 2 a 100 anos, nas regiões das estações do Mato Grosso

Liberação de K pelo flogopitito em um argissolo cultivado com coqueiro anão verde irrigado.

A quantidade de potássio removida pelo coqueiro é alta, pois a floração, a frutificação e a maturação dos frutos ocorrem simultânea e continuadamente, o que demanda adubações constantes. O KCl é a fonte de potássio mais usada no coqueiro. Entretanto o Brasil somente produz 12% do potássio que consome e a utilização de fontes alternativas poderá, portanto diminuir a dependência do País quanto ao citado insumo. O flogopitito é uma rocha que ocorre no estado da Bahia e que contem K em sua composição. O experimento está sendo conduzido em um Argissolo Amarelo do Platô de Néopolis, Sergipe. O delineamento experimental é de blocos ao acaso com sete tratamentos sendo três níveis de K2O 0,6, 1,2 e 1,8 kg planta-1 ano-1 e três níveis de flogopitito 7,56, 15,12 e 22,68 kg planta-1 ano-1 os quais são equivalentes aos níveis de K2O, mais uma testemunha sem K. As doses foram calculadas considerando 7,93 % de K2O no flogopitito e o limite de 5 t há-1. Os teores de K no solo diminuíram com o tempo em função da remoção pela cultura e ou lixiviação. Os dados indicam que o flogopitito liberou K durante o período

Soil carbon stock and indices in sandy soil afected by Eucalyptus Harvest residue management in the South of Brazil.

Abstract: There has been limited research on the effect of eucalyptus harvest residue management on soil organic carbon (SOC) in subtropical environments. This research evaluated the effect on soil C indices of the following eucalyptus harvest residue managements: AR, with all forest remnants left on the soil; NB, where bark was removed; NBr, in which branches were removed; NR, which removed all residues; and NRs, which is same as NR but also used a shade net to prevent the litter from the new plantation from reaching the soil surface. C stocks within the soil depths of 0?20 cm and 0?100 cm increased linearly with the C input from eucalyptus harvest residues. In the layer of 0?20 cm, the lowest soil C retention rate was 0.23 Mg ha−1 year−1, in the NR treatment, while in the AR treatment, the retention rate was 0.68 Mg ha−1 year−1. In the 0?100 cm layer, the highest C retention rate was obtained in the AR (1.47 Mg ha−1 year−1). The residues showed a high humification coefficient (k1 = 0.23) and a high soil organic matter decomposition rate (k2 = 0.10). The carbon management index showed a close relationship with the C input and tree diameter at breast height

Prospecção de fungos associados a sementes de maracujá no Estado da Bahia.

O Brasil é um dos maiores produtores mundiais de maracujá (Passiflora edulis), destacandose, neste cenário, o Estado da Bahia, com 51% da área destinada à colheita e 41% da produção nacional

A soil quality index for subtropical sandy soils under different Eucalyptus harvest residue managements.

Eucalyptus harvest residues are attractive energy production resources for the forestry industry. However, their removal can have adverse impacts on soil quality and forest productivity, especially in sandy soils. In this study, we assessed the effects of Eucalyptus harvest residue managements with variable intensity on forest productivity and on physical, chemical, and biological indicators of the soil quality. The experiment was conducted in a Quartzipsamment (33 g kg− 1 clay) planted with Eucalyptus saligna in Barra do Ribeiro in southern Brazil. Before the Eucalyptus was planted, residues from the previous rotation were subjected to five different management treatments: (1) FRM, in which all forest residues (bark, branches, leaves, and litter) were allowed to remain on the soil and only trunk wood was removed; (2) FRMB, in which was identical to FRM except that bark was also removed; (3) FRMBr, in which only trunk wood and branches were removed; (4) FRR, which involved removing all types of residues (bark, branches, leaves, and litter); and, (5) FRRs, in which all forest residues from the previous rotation were removed, and leaves and branches from the new plantation were prevented from falling onto the soil surface using a shade net. Six years after planting, soil samples were collected at four different depths (0–2.5, 2.5–5, 5–10, and 10–20 cm) to determine 17 soil chemical, physical, and biological indicators. The results were combined into a soil quality index (SQI) using the principal component analysis approach. The SQI reduced by 30%, in the 0–20 cm layer, due to removal of harvest residues from the previous rotation, and collection of litter before it falls on the ground. The main drivers of SQI reduction were the principal components associated with soil organic matter and biological activity. Furthermore, the SQI was positively linearly related to tree height at P < 0.01 and to tree diameter at breast height at P = 0.07. The adverse impact on soil quality and forest productivity in our study indicates that removal of Eucalyptus harvest residues from sandy soils should be avoided