COVID-19 vaccine hesitancy among health and social care workers during mass vaccination in Scotland

Health and social care workers (HSCWs) have an essential role in the uptake of the COVID-19 vaccine. Vaccination is an emotionally charged issue and perceptions of risk associated with COVID19 can contribute towards vaccine hesitancy (VH). The aim of this study was to explore the role of emotion and risk perception associated with HSCWs' uptake of the COVID-19 vaccine during the initial mass roll-out of the vaccine in Scotland. A cross-sectional online survey with a correlational design was used. An online survey was conducted with HSCWs (N = 1189) aged 18 to 67 years (M = 44.09 yrs, SD = 11.48) working in Scotland during the third lockdown period (December 26th – March 31st 2021) of the COVID-19 pandemic. The survey collected data relating to sociodemographic characteristics, vaccine uptake and VH, emotions associated with the COVID-19 vaccine, and risk perception. Open-ended free text data were also collected on HSCWs’ main reasons for VH. Most participants (83.96%) felt positively about the roll-out of the COVID-19 vaccine, stating it would be beneficial for themselves and others to receive it. Nonetheless, 16.04% of HSCWs expressed VH. Occupational group, age, gender and risk perceptions did not affect variance in VH, but positive emotions associated with the COVID-19 vaccine and years of experience did. We emphasise the importance of future interventions to increase COVID-19 vaccine uptake by enhancing positive emotions and reducing ambivalent emotions associated with the COVID-19 vaccine particularly among less experienced HSCWs

Decorin reduces intraocular pressure and retinal ganglion cell loss in rodents through fibrolysis of the scarred trabecular meshwork

Purpose. To investigate whether Decorin, a matrikine that regulates extracellular matrix (ECM) deposition, can reverse established trabecular meshwork (TM) fibrosis, lower IOP, and reduce progressive retinal ganglion cell (RGC) death in a novel rodent model of TM fibrosis. Methods. Adult rats had intracameral (IC) injections of human recombinant (hr) TGF-β over 30 days (30d; to induce TM fibrosis, raise IOP, and initiate RGC death by 17d) or PBS (controls) and visually evoked potentials (VEP) were measured at 30d to evaluate resultant visual pathway dysfunction. In some animals TGF-β injections were stopped at 17d when TM fibrosis and IOP were consistently raised and either hrDecorin or PBS IC injections were administered between 21d and 30d. Intraocular pressure was measured biweekly and eyes were processed for immunohistochemical analysis of ECM deposition to assess TM fibrosis and levels of matrix metalloproteinases (MMP) and tissue inhibitors of matrix metalloproteinases (TIMP) to assess fibrolysis. The effect of hrDecorin treatment on RGC survival was also assessed. Results. Transforming growth factor–β injections caused sustained increases in ECM deposition in the TM and raised IOP by 17d, responses that were associated with 42% RGC loss and a significant decrease in VEP amplitude measured at 30d. Decorin treatment from 17d reduced TGF-β–induced TM fibrosis, increased levels of MMP2 and MMP9 and lowered TIMP2 levels, and lowered IOP, preventing progressive RGC loss. Conclusions. Human recombinant Decorin reversed established TM fibrosis and lowered IOP, thereby rescuing RGC from progressive death. These data provide evidence for the candidacy of hrDecorin as a treatment for open-angle glaucoma

The Grizzly, February 7, 1986

Refrigerators are Still a Hot Issue • Bridge Reopens • Nursing Homes: Investigation II • Letters: Controversial Issue has no Basis; Space Shuttle: Tragedy Turned Spectacle; Times are Changing • USGA Election Candidates • Mer Chicks Take Two • Mermen Drown W. Maryland • Bears No. 2 in MAC • Lady Bears Thrash Haverford • Gymnasts Take Bryn Mawr • A Tough Job Gets Recognition • Track Team Impressive at Widener • Lab Manual to be Rewritten • Open Dialog: Women Ministers • Coulter Chosen MVPhttps://digitalcommons.ursinus.edu/grizzlynews/1156/thumbnail.jp

ENACT study : what has helped health and social care workers maintain their mental wellbeing during the COVID-19 pandemic?

A growing body of research has highlighted the adverse impact of COVID-19 stressors on health and social care workers’ (HSCWs) mental health. Complementing this work, we report on the psychosocial factors that have had both a positive and negative impact on the mental wellbeing of HSCWs during the third lockdown period in Scotland. Using a cross-sectional design, participants (n= 1364) completed an online survey providing quantitative data and free open-text responses. A multi-method approach to analysis was used. The majority of HSCWs were found to have low wellbeing scores, high levels of COVID-19 stress, worry, burnout and risk perception scores and almost half of HSCWs met the clinical cut off for acute stress (indicative of PTSD). HSCWs with higher scores on adaptive coping strategies and team resilience reported higher scores on mental wellbeing. HSCWs were significantly more likely to seek informal support for dealing with personal or emotional problems compared to formal supports. Barriers to formal help-seeking were identified including stigma and fear of the consequences of disclosure. HSCWs mostly valued peer support, workplace supports, visible leadership and teamwork in maintaining their mental wellbeing. Our findings illuminate the complexity of the effects of the COVID-19 pandemic on HSCWs’ wellbeing and will inform future intervention development seeking to increase positive adaptation and improve staff wellbeing. Addressing barriers to mental health help-seeking among HSCWs is essential. The implications emphasise the importance of lessons learned across health and social care contexts, planning and preparedness for future pandemics

Domestication of Campylobacter jejuni NCTC 11168

Reference and type strains of well-known bacteria have been a cornerstone of microbiology research for decades. The sharing of well-characterized isolates among laboratories has run in parallel with research efforts and enhanced the reproducibility of experiments, leading to a wealth of knowledge about trait variation in different species and the underlying genetics. Campylobacter jejuni strain NCTC 11168, deposited at the National Collection of Type Cultures in 1977, has been adopted widely as a reference strain by researchers worldwide and was the first Campylobacter for which the complete genome was published (in 2000). In this study, we collected 23 C . jejuni NCTC 11168 reference isolates from laboratories across the UK and compared variation in simple laboratory phenotypes with genetic variation in sequenced genomes. Putatively identical isolates, identified previously to have aberrant phenotypes, varied by up to 281 SNPs (in 15 genes) compared to the most recent reference strain. Isolates also display considerable phenotype variation in motility, morphology, growth at 37 °C, invasion of chicken and human cell lines, and susceptibility to ampicillin. This study provides evidence of ongoing evolutionary change among C. jejuni isolates as they are cultured in different laboratories and highlights the need for careful consideration of genetic variation within laboratory reference strains. This article contains data hosted by Microreact

I fell out of my standing. Falls narratives, ageism and socio-medical understanding of falls in older persons

There is a wealth of research addressing falls aetiology in older persons. This may be framed within western world, ageing demographics and financial concerns that require evidence of effective bio-medical interventions (Kingston 2000). Drawing on older persons’ falls narratives and building on a small body of work (see, for example, Horton and Arber 2004; Kingston 2000; McKee et al 1999; Yardley 2004), this paper highlights ways in which fallers view falls and calls for complementary, social and cultural analyses. In so doing, negative culturally and linguistically embedded notions of falling in relation to ageing, usefulness, personal control, autonomy, social embarrassment and social standing, may be challenged. In turn, the ‘faller’ may position him- or herself beyond connotations of ‘loss of control’ and decline (Horton and Arber 2004; McKee et al 1999)

“I fell out of my standing”: falls, narratives and the language of ageing

There is a wealth of research addressing falls aetiology in older persons. This may be framed within western world, ageing demographics and financial concerns that require evidence of effective bio-medical interventions (Kingston 2000). Drawing on older persons’ falls narratives and building on a small body of work (see, for example, Horton and Arber 2004; Kingston 2000; McKee et al 1999; Yardley 2004), this paper highlights ways in which fallers view falls and calls for complementary, social and cultural analyses. In so doing, negative culturally and linguistically embedded notions of falling in relation to ageing, usefulness, personal control, autonomy, social embarrassment and social standing, may be challenged. In turn, the ‘faller’ may position him- or herself beyond connotations of ‘loss of control’ and decline (Horton and Arber 2004; McKee et al 1999). The falls narratives have been collected as part of an ongoing, multi-sited and multi-disciplinary Irish study Technologies for Independent Living (TRIL) that is addressing physical, cognitive and social consequences of ageing. Narrative data collection is part of an ethnography underpinning this large study.* This includes falls histories taken at the time of telephone recruitment by a clinical nurse manager and during a comprehensive medical assessment within a clinic setting and an audio recorded, qualitative interview in study participants’ homes. Collection of falls narratives is ongoing and the following discussion is developed from the recruitment and medical falls history-taking of twenty TRIL participants and the qualitative interviews of eight further participants. Exploration of falls narratives offers insights into negative and pervasive associations between ageing and falling that can culturally inform clinicians’ understanding of falls. The paper also reflects on how this understanding is being used to develop falls prevention technologies