Guns and Option Derivatives Are Rights: Two Must Be Analogously Priced

Financial derivatives and guns can be significantly valuable tools. They can also be “weapons of mass destruction” that impose externalities on society. The last few years have demonstrated the need for stricter regulation, particularly regulation concerning risk-taking, in relation to both. In light of those externalities, laws and regulations used to identify, monitor, and mitigate risks are essential and legal intervention to regulate the risk of such externalities is justified. Regulation concerning risk-taking does carry high economic and social costs and should be carefully crafted. We posit that both guns and option derivatives are rights and must be appropriately priced to benefit society

The roles of neutrophils in non-tuberculous mycobacterial pulmonary disease

Non-tuberculous Mycobacterial Pulmonary Disease (NTM-PD) is an increasingly recognised global health issue. Studies have suggested that neutrophils may play an important role in controlling NTM infection and contribute to protective immune responses within the early phase of infection. However, these cells are also adversely associated with disease progression and exacerbation and can contribute to pathology, for example in the development of bronchiectasis. In this review, we discuss the key findings and latest evidence regarding the diverse functions of neutrophils in NTM infection. First, we focus on studies that implicate neutrophils in the early response to NTM infection and the evidence reporting neutrophils' capability to kill NTM. Next, we present an overview of the positive and negative effects that characterise the bidirectional relationship between neutrophils and adaptive immunity. We consider the pathological role of neutrophils in driving the clinical phenotype of NTM-PD including bronchiectasis. Finally, we highlight the current promising treatments in development targeting neutrophils in airways diseases. Clearly, more insights on the roles of neutrophils in NTM-PD are needed in order to inform both preventative strategies and host-directed therapy for these important infections

Differences in evolutionary pressure acting within highly conserved ortholog groups

<p>Abstract</p> <p>Background</p> <p>In highly conserved widely distributed ortholog groups, the main evolutionary force is assumed to be purifying selection that enforces sequence conservation, with most divergence occurring by accumulation of neutral substitutions. Using a set of ortholog groups from prokaryotes, with a single representative in each studied organism, we asked the question if this evolutionary pressure is acting similarly on different subgroups of orthologs defined as major lineages (e.g. Proteobacteria or Firmicutes).</p> <p>Results</p> <p>Using correlations in entropy measures as a proxy for evolutionary pressure, we observed two distinct behaviors within our ortholog collection. The first subset of ortholog groups, called here informational, consisted mostly of proteins associated with information processing (i.e. translation, transcription, DNA replication) and the second, the non-informational ortholog groups, mostly comprised of proteins involved in metabolic pathways. The evolutionary pressure acting on non-informational proteins is more uniform relative to their informational counterparts. The non-informational proteins show higher level of correlation between entropy profiles and more uniformity across subgroups.</p> <p>Conclusion</p> <p>The low correlation of entropy profiles in the informational ortholog groups suggest that the evolutionary pressure acting on the informational ortholog groups is not uniform across different clades considered this study. This might suggest "fine-tuning" of informational proteins in each lineage leading to lineage-specific differences in selection. This, in turn, could make these proteins less exchangeable between lineages. In contrast, the uniformity of the selective pressure acting on the non-informational groups might allow the exchange of the genetic material via lateral gene transfer.</p

GenBank

GenBank (R) is a comprehensive database that contains publicly available nucleotide sequences for more than 240 000 named organisms, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the web-based BankIt or standalone Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the EMBL Data Library in Europe and the DNA Data Bank of Japan ensures worldwide coverage. GenBank is accessible through NCBI's retrieval system, Entrez, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI Homepage ()

Rapid magma generation or shared magmatic reservoir? Petrology and geochronology of the Rat Creek and Nelson Mountain Tuffs, CO, USA

This study was supported by the ETH Research Grant ETH-34 15-2 (JS).Large-volume silicic volcanism poses global hazards in the form of proximal pyroclastic density currents, distal ash fall and short-term climate perturbations, which altogether warrant the study of how silicic magma bodies evolve and assemble. The southern rocky mountain volcanic field (SRMVF) is home to some of the largest super-eruptions in the geological record, and has been studied to help address the debate over how quickly eruptible magma batches can be assembled–whether in decades to centuries, or more slowly over 100’s of kyr. The present study focuses on the San Luis caldera complex within the SRMVF, and discusses the paradigms of rapid magma generation vs. rapid magma assembly. The caldera complex consists of three overlapping calderas that overlie the sources of three large-volume mid-Cenozoic ignimbrites: first, the Rat Creek Tuff (RCT; zoned dacite-rhyolite, 150 km3), followed by the Cebolla Creek Tuff (mafic dacite, 250 km3) and finally, the Nelson Mountain Tuff (NMT; zoned dacite-rhyolite, 500 km3), which are all indistinguishable in age by 40Ar/39Ar dating. We argue for a shared magmatic history for the three units on the basis of (1) similar mineral trace element compositions in the first and last eruptions (plagioclase, sanidine, biotite, pyroxene, amphibole, titanite, and zircon), (2) overlapping zircon U-Pb ages in all three units, and (3) similar thermal rejuvenation signatures visible in biotite (low-Mn, high-Ba) and zircon (low-Hf, low-U) geochemistry within the RCT and NMT. It is postulated that the NMT was sourced from a pre-existing magma reservoir to the northeast, which is corroborated by the formation of the nearby Cochetopa Caldera during the eruption of the NMT. The inferred lateral magma transport has two important implications: (1) it demonstrates long-distance transport of highly viscosity magmas at volumes (100’s of km3) not previously recorded, and (2) the sourcing of magma from a nearby pre-existing magma reservoir greatly reduces the rate of magma generation necessary to explain the close coincidence of three overlapping, large-volume magma systems. Additionally, the concept of magmatic “flux” (km3 kyr−1) is discussed in this context, and it is argued that an area-normalized flux (km3 kyr–1 km−2) provides a more useful number for measuring magma production rates: it is expected that magmatic volumes will scale with footprint of the thermal anomaly, and not taking this into account may lead to errant volumetric flux (km3 kyr−1) estimates. Meanwhile, area-normalized flux estimates in a given area are similar between units, consistent with evolution in a relatively constant thermal regime. Such estimates also demonstrate similar fluxes for ∼cogenetic volcanic and plutonic units.Publisher PDFPeer reviewe

The relationship of protein conservation and sequence length

BACKGROUND: In general, the length of a protein sequence is determined by its function and the wide variance in the lengths of an organism's proteins reflects the diversity of specific functional roles for these proteins. However, additional evolutionary forces that affect the length of a protein may be revealed by studying the length distributions of proteins evolving under weaker functional constraints. RESULTS: We performed sequence comparisons to distinguish highly conserved and poorly conserved proteins from the bacterium Escherichia coli, the archaeon Archaeoglobus fulgidus, and the eukaryotes Saccharomyces cerevisiae, Drosophila melanogaster, and Homo sapiens. For all organisms studied, the conserved and nonconserved proteins have strikingly different length distributions. The conserved proteins are, on average, longer than the poorly conserved ones, and the length distributions for the poorly conserved proteins have a relatively narrow peak, in contrast to the conserved proteins whose lengths spread over a wider range of values. For the two prokaryotes studied, the poorly conserved proteins approximate the minimal length distribution expected for a diverse range of structural folds. CONCLUSIONS: There is a relationship between protein conservation and sequence length. For all the organisms studied, there seems to be a significant evolutionary trend favoring shorter proteins in the absence of other, more specific functional constraints

GenBank

GenBank(R) is a comprehensive database that contains publicly available nucleotide sequences for more than 380,000 organisms named at the genus level or lower, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the European Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage. GenBank is accessible through the NCBI Entrez retrieval system that integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI Homepage: https://www.ncbi.nlm.nih.gov