Blocking Nuclear Factor-Kappa B Protects against Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice

Inflammation critically contributes to the development of various metabolic diseases. However, the effects of inhibiting inflammatory signaling on hepatic steatosis and insulin resistance, as well as the underlying mechanisms remain obscure. In the current study, male C57BL/6J mice were fed a chow diet or high-fat diet (HFD) for 8 weeks. HFD-fed mice were respectively treated with p65 siRNA, non-silence control siRNA or vehicle every 4th day for the last 4 weeks. Vehicle-treated (HF) and non-silence siRNA-treated (HFNS) mice displayed overt inflammation, hepatic steatosis and insulin resistance compared with chow-diet-fed (NC) mice. Upon treatment with NF-κB p65 siRNA, HFD-fed (HFPS) mice were protected from hepatic steatosis and insulin resistance. Furthermore, Atg7 and Beclin1 expressions and p-AMPK were increased while p-mTOR was decreased in livers of HFPS mice in relative to HF and HFNS mice. These results suggest a crosslink between NF-κB signaling pathway and liver AMPK/mTOR/autophagy axis in the context of hepatic steatosis and insulin resistance

Bessel terahertz pulses from superluminal laser plasma filaments

Terahertz radiation with a Bessel beam profile is demonstrated experimentally from a two-color laser filament in air, which is induced by tailored femtosecond laser pulses with an axicon. The temporal and spatial distributions of Bessel rings of the terahertz radiation are retrieved after being collected in the far field. A theoretical model is proposed, which suggests that such Bessel terahertz pulses are produced due to the combined effects of the inhomogeneous superluminal filament structure and the phase change of the two-color laser components inside the plasma channel. These two effects lead to wavefront crossover and constructive/destructive interference of terahertz radiation from different plasma sources along the laser filament, respectively. Compared with other methods, our technique can support the generation of Bessel pulses with broad spectral bandwidth. Such Bessel pulses can propagate to the far field without significant spatial spreading, which shall provide new opportunities for terahertz applications

OWL: A Large Language Model for IT Operations

With the rapid development of IT operations, it has become increasingly crucial to efficiently manage and analyze large volumes of data for practical applications. The techniques of Natural Language Processing (NLP) have shown remarkable capabilities for various tasks, including named entity recognition, machine translation and dialogue systems. Recently, Large Language Models (LLMs) have achieved significant improvements across various NLP downstream tasks. However, there is a lack of specialized LLMs for IT operations. In this paper, we introduce the OWL, a large language model trained on our collected OWL-Instruct dataset with a wide range of IT-related information, where the mixture-of-adapter strategy is proposed to improve the parameter-efficient tuning across different domains or tasks. Furthermore, we evaluate the performance of our OWL on the OWL-Bench established by us and open IT-related benchmarks. OWL demonstrates superior performance results on IT tasks, which outperforms existing models by significant margins. Moreover, we hope that the findings of our work will provide more insights to revolutionize the techniques of IT operations with specialized LLMs.Comment: 31 page

Frequency tuning for broadband terahertz emission from two-color laser-induced air plasma

Effective manipulation of broadband terahertz emission, especially on spectrum tuning, is of great importance for many applications. We demonstrate a method to realize frequency tuning of terahertz emissions from two-color laser-induced air plasmas. The terahertz central frequency is switched from 0.56 to 0.82 THz by changing the polarization state of the fundamental wave with a quarter-wave plate. Based on numerical simulation, it is found that this frequency tuning is due to the birefringence effect induced by the fundamental wave on the second harmonic inside the filament, which leads to a discrepancy on the polarization chirality of the two-color laser components. Two-color lasers with opposite chirality will emit terahertz radiation with higher central frequency compared to two-color lasers with the same chirality at moderate laser intensity.</jats:p

Measurement and Control of Radially Polarized THz Radiation from DC-Biased Laser Plasma Filaments in Air

Detection and manipulation of radially polarized terahertz (THz) radiation is essential for many applications. A new measurement scheme is proposed for the diagnosis of radially polarized THz radiation from a longitudinal dc-biased plasma filament, by introducing a movable metal mask. The amplitude and spectrum of the radially polarized THz beam was measured with a &lt;110&gt;-cut ZnTe crystal, where the THz beam pattern was modulated by the mask. Based on this measurement scheme, it was demonstrated that the amplitude and spectrum of the radially polarized THz radiation from the longitudinal dc-biased filament could be manipulated by controlling the strength and the location of the dc-biased field.</jats:p

Measurement and Control of Radially Polarized THz Radiation from DC-Biased Laser Plasma Filaments in Air

Detection and manipulation of radially polarized terahertz (THz) radiation is essential for many applications. A new measurement scheme is proposed for the diagnosis of radially polarized THz radiation from a longitudinal dc-biased plasma filament, by introducing a movable metal mask. The amplitude and spectrum of the radially polarized THz beam was measured with a &lt;110&gt;-cut ZnTe crystal, where the THz beam pattern was modulated by the mask. Based on this measurement scheme, it was demonstrated that the amplitude and spectrum of the radially polarized THz radiation from the longitudinal dc-biased filament could be manipulated by controlling the strength and the location of the dc-biased field