Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

We conducted genome-wide association study (GWAS) meta-analyses of relative caloric intake from fat, protein, carbohydrates and sugar in over 235,000 individuals. We identified 21 approximately independent lead SNPs. Relative protein intake exhibits the strongest relationships with poor health, including positive genetic associations with obesity, type 2 diabetes, and heart disease ( ≈ 0.15 − 0.5). Relative carbohydrate and sugar intake have negative genetic correlations with waist circumference, waist-hip ratio, and neighborhood poverty (|| ≈ 0.1 − 0.3). Overall, our results show that the relative intake of each macronutrient has a distinct genetic architecture and pattern of genetic correlations suggestive of health implications beyond caloric content

Cable-driven parallel robot for curtain wall module installation

A cable-driven parallel robot (CDPR) was developed for the installation of curtain wall modules (CWM). The research addressed the question of whether the CDPR was capable installing CWMs with sufficient accuracy while being competitive compared to conventional manual methods. In order to develop and test such a system, a conceptual framework that consisted of three sub-systems was defined. The tests, carried out in two close-to-real demonstration buildings, revealed an absolute accuracy of the CWM installation of 4 to 23 mm. The working time for installing a CWM was reduced to 0.51 h. The results also show that the system is competitive for a workspace greater than 96 m2 compared to conventional manual methods. However, improvements such as reducing the hours for setting up the CDPR on the one hand and achieving a faster and more robust MEE on the other hand will be still necessary in the future.This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 73251

In-orbit aerodynamic coefficient measurements using SOAR (Satellite for Orbital Aerodynamics Research)

The Satellite for Orbital Aerodynamics Research (SOAR) is a CubeSat mission, due to be launched in 2021, to investigate the interaction between different materials and the atmospheric flow regime in very low Earth orbits (VLEO). Improving knowledge of the gas–surface interactions at these altitudes and identification of novel materials that can minimise drag or improve aerodynamic control are important for the design of future spacecraft that can operate in lower altitude orbits. Such satellites may be smaller and cheaper to develop or can provide improved Earth observation data or communications link-budgets and latency. In order to achieve these objectives, SOAR features two payloads: (i) a set of steerable fins which provide the ability to expose different materials or surface finishes to the oncoming flow with varying angle of incidence whilst also providing variable geometry to investigate aerostability and aerodynamic control; and (ii) an ion and neutral mass spectrometer with time-of-flight capability which enables accurate measurement of the in-situ flow composition, density, velocity. Using precise orbit and attitude determination information and the measured atmospheric flow characteristics the forces and torques experienced by the satellite in orbit can be studied and estimates of the aerodynamic coefficients calculated. This paper presents the scientific concept and design of the SOAR mission. The methodology for recovery of the aerodynamic coefficients from the measured orbit, attitude, and in-situ atmospheric data using a least-squares orbit determination and free-parameter fitting process is described and the experimental uncertainty of the resolved aerodynamic coefficients is estimated. The presented results indicate that the combination of the satellite design and experimental methodology are capable of clearly illustrating the variation of drag and lift coefficient for differing surface incidence angle. The lowest uncertainties for the drag coefficient measurement are found at approximately 300 km, whilst the measurement of lift coefficient improves for reducing orbital altitude to 200 km

Intake Design for an Atmosphere-Breathing Electric Propulsion System (ABEP)

Challenging space missions include those at very low altitudes, where the atmosphere is source of aerodynamic drag on the spacecraft. To extend the lifetime of such missions, an efficient propulsion system is required. One solution is Atmosphere-Breathing Electric Propulsion (ABEP) that collects atmospheric particles to be used as propellant for an electric thruster. The system would minimize the requirement of limited propellant availability and can also be applied to any planetary body with atmosphere, enabling new missions at low altitude ranges for longer times. IRS is developing, within the H2020 DISCOVERER project, an intake and a thruster for an ABEP system. The article describes the design and simulation of the intake, optimized to feed the radio frequency (RF) Helicon-based plasma thruster developed at IRS. The article deals in particular with the design of intakes based on diffuse and specular reflecting materials, which are analysed by the PICLas DSMC-PIC tool. Orbital altitudes $h=150-250$ km and the respective species based on the NRLMSISE-00 model (O, $N_2$, $O_2$, He, Ar, H, N) are investigated for several concepts based on fully diffuse and specular scattering, including hybrid designs. The major focus has been on the intake efficiency defined as $\eta_c=\dot{N}_{out}/\dot{N}_{in}$, with $\dot{N}_{in}$ the incoming particle flux, and $\dot{N}_{out}$ the one collected by the intake. Finally, two concepts are selected and presented providing the best expected performance for the operation with the selected thruster. The first one is based on fully diffuse accommodation yielding to $\eta_c<0.46$ and the second one based un fully specular accommodation yielding to $\eta_c<0.94$. Finally, also the influence of misalignment with the flow is analysed, highlighting a strong dependence of $\eta_c$ in the diffuse-based intake while, ...Comment: Accepted Versio

Intake design for an Atmosphere-Breathing Electric Propulsion System (ABEP)

Challenging space missions include those at very low altitudes, where the atmosphere is source of aerodynamic drag on the spacecraft. To extend the lifetime of such missions, an efficient propulsion system is required. One solution is Atmosphere-Breathing Electric Propulsion (ABEP) that collects atmospheric particles to be used as propellant for an electric thruster. The system would minimize the requirement of limited propellant availability and can also be applied to any planetary body with atmosphere, enabling new missions at low altitude ranges for longer times. IRS is developing, within the H2020 DISCOVERER project, an intake and a thruster for an ABEP system. The article describes the design and simulation of the intake, optimized to feed the radio frequency (RF) Helicon-based plasma thruster developed at IRS. The article deals in particular with the design of intakes based on diffuse and specular reflecting materials, which are analysed by the PICLas DSMC-PIC tool. Orbital altitudes and the respective species based on the NRLMSISE-00 model (O, , , He, Ar, H, N) are investigated for several concepts based on fully diffuse and specular scattering, including hybrid designs. The major focus has been on the intake efficiency defined as , with the incoming particle flux, and the one collected by the intake. Finally, two concepts are selected and presented providing the best expected performance for the operation with the selected thruster. The first one is based on fully diffuse accommodation yielding to and the second one based on fully specular accommodation yielding to . Finally, also the influence of misalignment with the flow is analysed, highlighting a strong dependence of in the diffuse-based intake while, for the specular-based intake, this is much lower finally leading to a more resilient design while also relaxing requirements of pointing accuracy for the spacecraft

RF Helicon-based Inductive Plasma Thruster (IPT) Design for an Atmosphere-Breathing Electric Propulsion system (ABEP)

Challenging space missions include those at very low altitudes, where the atmosphere is source of aerodynamic drag on the spacecraft. To extend such missions lifetime, an efficient propulsion system is required. One solution is Atmosphere-Breathing Electric Propulsion (ABEP). It collects atmospheric particles to be used as propellant for an electric thruster. The system would minimize the requirement of limited propellant availability and can also be applied to any planet with atmosphere, enabling new mission at low altitude ranges for longer times. Challenging is also the presence of reactive chemical species, such as atomic oxygen in Earth orbit. Such species cause erosion of (not only) propulsion system components, i.e. acceleration grids, electrodes, and discharge channels of conventional EP systems. IRS is developing within the DISCOVERER project, an intake and a thruster for an ABEP system. The paper describes the design and implementation of the RF helicon-based inductive plasma thruster (IPT). This paper deals in particular with the design and implementation of a novel antenna called the birdcage antenna, a device well known in magnetic resonance imaging (MRI), and also lately employed for helicon-wave based plasma sources in fusion research. This is aided by the numerical tool XFdtd®. The IPT is based on RF electrodeless operation aided by an externally applied static magnetic field. The IPT is composed by an antenna, a discharge channel, a movable injector, and a solenoid. By changing the operational parameters along with the novel antenna design, the aim is to minimize losses in the RF circuit, and accelerate a quasi-neutral plasma plume. This is also to be aided by the formation of helicon waves within the plasma that are to improve the overall efficiency and achieve higher exhaust velocities. Finally, the designed IPT with a particular focus on the birdcage antenna design procedure is presented

Genomic analysis of diet composition finds novel loci and associations with health and lifestyle

We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique, approximately independent lead SNPs. Fourteen lead SNPs are uniquely associated with one macronutrient at genome-wide significance (P < 5 x 10(-8)), while five of the 21 lead SNPs reach suggestive significance (P < 1 x 10(-5)) for at least one other macronutrient. While the phenotypes are genetically correlated, each phenotype carries a partially unique genetic architecture. Relative protein intake exhibits the strongest relationships with poor health, including positive genetic associations with obesity, type 2 diabetes, and heart disease (r(g) approximate to 0.15-0.5). In contrast, relative carbohydrate and sugar intake have negative genetic correlations with waist circumference, waist-hip ratio, and neighborhood deprivation (|r(g)| approximate to 0.1-0.3) and positive genetic correlations with physical activity (r(g) approximate to 0.1 and 0.2). Relative fat intake has no consistent pattern of genetic correlations with poor health but has a negative genetic correlation with educational attainment (r(g) approximate to-0.1). Although our analyses do not allow us to draw causal conclusions, we find no evidence of negative health consequences associated with relative carbohydrate, sugar, or fat intake. However, our results are consistent with the hypothesis that relative protein intake plays a role in the etiology of metabolic dysfunction.Public Health and primary carePrevention, Population and Disease management (PrePoD

An Affordable and Adaptable Building System to Transform Informal Settlements in Cairo

Today, approximately 70% of Greater Cairo’s 20 million inhabitants are living in urban informal settlements, and the number is expected to continuously increase. These informal settlements suffer from various issues such as overpopulation, high unemployment rate, land shortage, poor living conditions, inadequate infrastructures, and environmental pressures. This paper is a scientific summary of the results from the research project A²L-Mobilius, which is partly funded by the German Federal Ministry of Education and Research (Project: AL²MOBILIUS; Grant Number: GERF-IB-033 Almobilius_01DH14003). The goal of this research is to explore an integrated approach to improve the living condition of local residents as well as to revitalize the local communities. By investigating the context of informal settlements in Cairo, an Affordable and Adaptable Building System (A²BS) based on open building concepts is proposed, which can be easily prefabricated and assembled by unskilled labor. Meanwhile, Decentralized Processing Units (DPUs) tailored to the building system are introduced to enhance three main aspects of life (working, energy, and mobility). Finally, a simulation of a regenerated house based on selected case study building is presented, which integrates A²BS and various DPUs. Additionally, an appropriate business model for the future prosperity of the local communities is discussed in the context of Decentralized Industrial Village (DIV). In conclusion, this research will be a step forward to improve the living conditions of informal settlements in Cairo and worldwide