Pole analysis on the hadron spectroscopy of Λb→J/ΨpK−\Lambda_b\to J/\Psi p K^-

In this paper we study the $J/\Psi p$ spectroscopy in the process of $\Lambda_b\to J/\Psi p K^-$. The final state interactions of coupled channel $J/\Psi p$ ~-~ $\bar{D} \Sigma_c$~-~$\bar{D}^{*} \Sigma_c$ are constructed based on K-matrix with the Chew-Mandelstam function. We build the $\Lambda_b\to J/\Psi p K^-$ amplitude according to the Au-Morgan-Pennington method. The event shape is fitted and the decay width of $\Lambda_b\to J/\Psi p K^-$ is used to constrain the parameters, too. With the amplitudes we extract out the poles and their residues. Our amplitude and pole analysis suggest that the $P_c(4312)$ should be $\bar{D}\Sigma_c$ molecule, the $P_c(4440)$ could be an S-wave compact pentaquark state, and the structure around $P_c(4457)$ is caused by the cusp effect. The future experimental measurement of the decays of $\Lambda_b\to \bar{D}\Sigma_c K^-$ and $\Lambda_b\to \bar{D}^*\Sigma_c K^-$ would further help to study the nature of these resonances.Comment: updated to the published versio

Research Progress on Flavor Substances of Rice and Its Derivatives

As the main grain product in China， the flavor and quality of rice have attracted much attention.Different varieties or different producing areas may give rice unique flavor. The current methods of extracting rice flavor compounds (SAFE， SDE， SPME， P&T， SFE， etc.) were compared. The mechanism of producing rice flavor substances was discussed. Different rice varieties， growth environment， storage conditions， amylose content， cooking method， soaking time and so on would affect rice flavor， but the relationship between volatile matter and aroma is still not clear. However， 2-AP is generally considered to be a marker to distinguish aromatic rice from non aromatic rice. At the same time， the flavor compounds，processing methods， production mechanism and other thing of some rice derived foods were also listed. It provides a certain reference and theoretical basis for the recovery and application of rice flavor substances

Atherosclerosis and Helminths Infection

Atherosclerosis is a chronic disease that causes various cardiovascular complications. Plaque formation in atherosclerosis is considered similar to the pathogenesis of other autoimmune diseases; thus, immunomodulation and immunosuppression may present strategies for the treatment and prevention of these diseases. Interestingly helminth infection was found to inhibit T helper 1-mediated autoimmune diseases and T helper 2-mediated allergy and asthma, indicating significant potential for clinical application. Some study even found that therapeutic efficacy of the viable tapeworm was superior to dexamethasone treatment. Recently, some studies have shown an inverse association between helminth infections and inflammatory diseases, including diabetes mellitus, lipid abnormality, and atherosclerosis. Will the underlying mechanism bring us a new idea on the treatment for these diseases? We tried to find an answer by reviewing recent articles

Early Blockade of TLRs MyD88-Dependent Pathway May Reduce Secondary Spinal Cord Injury in the Rats

To determine the role of toll-like receptors (TLRs) myeloid differentiation factor 88 (MyD88) dependent pathway in the spinal cord secondary injury, compression injury was made at T8 segment of the spinal cord in adult male Sprague-Dawley rats. Shown by RT-PCR, TLR4 mRNA in the spinal cord was quickly elevated after compression injury. Intramedullary injection of MyD88 inhibitory peptide (MIP) resulted in significant improvement in locomotor function recovery at various time points after surgery. Meanwhile, injury area, p38 phosphorylation, and proinflammation cytokines in the injured spinal cord were significantly reduced in MIP-treated animals, compared with control peptide (CP) group. These data suggest that TLRs MyD88-dependent pathway may play an important role in the development of secondary spinal cord injury, and inhibition of this pathway at early time after primary injury could effectively protect cells from inflammation and apoptosis and therefore improve the functional recovery

Impervious surface change mapping with an uncertainty-based spatial-temporal consistency model: a case study in Wuhan city using Landsat time-series datasets from 1987 to 2016

Detailed information on the spatial-temporal change of impervious surfaces is important for quantifying the effects of rapid urbanization. Free access of the Landsat archive provides new opportunities for impervious surface mapping with fine spatial and temporal resolution. To improve the classification accuracy, a temporal consistency (TC) model may be applied on the original classification results of Landsat time-series datasets. However, existing TC models only use class labels, and ignore the uncertainty of classification during the process. In this study, an uncertainty-based spatial-temporal consistency (USTC) model was proposed to improve the accuracy of the long time series of impervious surface classifications. In contrast to existing TC methods, the proposed USTC model integrates classification uncertainty with the spatial-temporal context information to better describe the spatial-temporal consistency for the long time-series datasets. The proposed USTC model was used to obtain an annual map of impervious surfaces in Wuhan city with Landsat Thematic Mapper (TM), Enhanced Thematic Mapper (ETM+), and Operational Land Imager (OLI) images from 1987 to 2016. The impervious surfaces mapped by the proposed USTC model were compared with those produced by the support vector machine (SVM) classifier and the TC model. The accuracy comparison of these results indicated that the proposed USTC model had the best performance in terms of classification accuracy. The increase of overall accuracy was about 4.23% compared with the SVM classifier, and about 1.79% compared with the TC model, which indicates the effectiveness of the proposed USTC model in mapping impervious surfaces from long-term Landsat sensor imagery

Study on the relationship of acute ketosis intoxication and type 2 diabetes mellitus

AbstractObjectiveTo study the change of serum C-reactive protein (CRP) levels and its correlation with ketosis in type 2 diabetes mellitus patients with acute ketosis intoxication.MethodsA retrospective analysis was conducted for the patients with type 2 diabetes mellitus from August 2015 to January 2016. The patients combined with ketosis were included into diabetic ketosis group and the patients without ketosis were included into negative control group. The clinical data were collected from two groups including general data, blood pressure, liver function and the levels of blood fat, glycosylated hemoglobin, blood ketone, β-hydroxybutyric acid and CRP. The discrepancy of clinical data between two groups was analyzed.ResultsThe levels of glycosylated hemoglobin [(11.6 ± 2.1)% vs. (8.3 ± 1.9)%], blood ketone [0.65 (0.3, 1.75) vs. 0.1 (0.1, 0.2) mmol/L], β-hydroxybutyric acid [0.595 (0.303, 1.775) vs. 0.08 (0.06, 0.15) mmol/L] and CRP [0.595 (0.303, 1.775) vs. 0.08 (0.06, 0.15) mmol/L] were significant higher than those of negative control group, while the levels of blood pressure, blood fat and aminopherase had no significant difference. The serum CRP levels showed positive correlation with blood ketone and β-hydroxybutyric acid (r = 0.490 and r = 0.478, respectively).ConclusionsPoor blood glucose control for a long time and strengthening inflammatory response are correlated with the status of acute ketosis in type 2 diabetes mellitus patients. The CRP levels in ketosis patients were significantly elevated and could be used to evaluate the degree of ketosis

Developmental Profiles of Preschool Children With Spastic Diplegic and Quadriplegic Cerebral Palsy

Cerebral palsy (CP) is a disorder of movement and posture control with multiple impairments. The clinical manifestations of CP vary among children. The aim of this study was to compare the developmental profiles of preschool children with either of two types of CP: spastic diplegic (SD) CP and spastic quadriplegic (SQ) CP. Relationships between the children's various developmental functions were also investigated. We recruited 137 children with spastic CP, aged 1-5 years (mean age = 3.7 ± 2.1 years), and we classified them into two groups: SD (n = 59) and SQ (n = 78). The comparison group comprised 18 children with typical development. Developmental functions were assessed in all the children, using the Chinese Child Development Inventory with the updated norms. This scale addressed eight functional domains: gross motor ability, fine motor ability, expressive language ability, concept comprehension ability, situation comprehension ability, self-help ability, personal-social skills, and general development. A development quotient (DQ) was determined for each domain as a percentage of the developmental age divided by the chronological age. The developmental profiles of the CP subtypes were found to differ. Children with SQ were found to have lower DQs than those with SD (p < 0.01). There was also a difference in the distribution of DQs between the SD and SQ groups, although the lowest DQ in both groups was for the gross motor domain. An uneven delay in the development of gross motor function was found in both groups of children with CP. Motor functions, including gross motor and fine motor functions, were significantly related to self-help ability. Complex and significant correlations among developmental functions were also identified in children with CP. The findings in the present study may allow clinicians to anticipate the developmental profile of children with CP on the basis of whether they have the SD or SQ subtype. This, in turn, is likely to facilitate individual assessment, goal setting, and the planning of interventions in children with CP

Lysosome-Membrane Fusion Mediated Superoxide Production in Hyperglycaemia-Induced Endothelial Dysfunction

Lysosomal exocytosis and fusion to cellular membrane is critical in the oxidative stress formation of endothelium under apoptotic stimulus. We investigated the role therein of it in hyperglycaemia-induced endothelial dysfunction. The lysosome-membrane fusion was shown by the expression of lamp1, the lysosomal membrane marker, on cellular membrane and the transportation of lysosomal symbolic enzymes into cultural medium. We also examined the ceramide production, lipid rafts (LRs) clustering, colocalization of gp91phox, a NADPH oxidase subunit (NOX) to LRs clusters, superoxide (O2.-) formation and nitric oxide (NO) content in human umbilical vein endothelial cells (HUVEC) and the endothelium-dependent NO-mediated vasodilation in isolated rat aorta. As compared to normal glucose (5.6 mmol/l, Ctrl) incubation, high glucose (22 mmol/l, HG) exposure facilitated the lysosome-membrane fusion in HUVEC shown by significantly increased quantity of lamp1 protein on cellular membrane and enhanced activity of lysosomal symbolized enzymes in cultural medium. HG incubation also elicited ceramide generation, LRs clustering and gp91phox colocalization to LRs clusters which were proved to mediate the HG induced O2.- formation and NO depletion in HUVEC. Functionally, the endothelium-dependent NO-mediated vasodilation in aorta was blunted substantially after HG incubation. Moreover, the HG-induced effect including ceramide production, LRs clustering, gp91phox colocalization to LRs clusters, O2.- formation and endothelial dysfunction could be blocked significantly by the inhibition of lysosome-membrane fusion. We propose that hyperglycaemia-induced endothelial impairment is closely related to the lysosome-membrane fusion and the following LRs clustering, LRs-NOX platforms formation and O2.- production