886 research outputs found
Macroscopical Entangled Coherent State Generator in V configuration atom system
In this paper, we propose a scheme to produce pure and macroscopical
entangled coherent state. When a three-level ''V'' configuration atom interacts
with a doubly reasonant cavity, under the strong classical driven condition,
entangled coherent state can be generated from vacuum fields. An analytical
solution for this system under the presence of cavity losses is also given
Long-term culture captures injury-repair cycles of colonic stem cells
The colonic epithelium can undergo multiple rounds of damage and repair, often in response to excessive inflammation. The responsive stem cell that mediates this process is unclear, in part because of a lack of in vitro models that recapitulate key epithelial changes that occur in vivo during damage and repair. Here, we identify a Hop
Human Papillomaviruses and Papillomatosis Lesions of the Female Lower Genital Tract
Objective: The objective of this study was to determine whether human
papillomavirus (HPV) infections are involved in the development of papillomatosis lesions
of the lower female genital tract
Selection of Pru p 3 hypoallergenic peach and nectarine varieties
To the Editor, Peach is an important fruit consumed worldwide. However, it is also one of the most frequently reported allergenic fruits.1 Component diagnosis of peach allergy indicates Pru p 1, Pru p 2, Pru p 3, Pru p 4, Pru p 7, and Pru p 9 are involved.2, 3 Pru p 3 is the dominant allergen responsible for severe allergic reaction,4 and it is considered to be the primary sensitizer to other LTPs in Mediterranean and Central Europe.5 The levels of Pru p 3 differ between varieties.6 To date, measurement of Pru p 3 in a limited number of peach and nectarines from Spain, United States, and Italy has been reported.7 Significant variation of allergen concentration in processed foods containing peach has also been observed.8 The content of Pru p 3 of peach/nectarine determines the potential risk for peach allergic patients. China is the origin of peach with representative genetic diversity to be explored for hypoallergenic varieties.9 A core collection of 103 varieties cultivated in Jiaxing, Zhejiang Province were selected to represent this diversity, including 23 nectarines and 80 peach varieties (with fruit hair, round or flat, 77 cultivated, three wild) (Table S1). The soluble solid content (SSC), ripening date, and peach aroma intensity were recorded. Specific methods are detailed in the Supporting Information. Pru p 3 was quantified by ELISA based on our previous research.6info:eu-repo/semantics/publishedVersio
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Exosomes and Their Therapeutic Potentials of Stem Cells
Exosomes, a group of vesicles originating from the multivesicular bodies (MVBs), are released into the extracellular space when MVBs fuse with the plasma membrane. Numerous studies indicate that exosomes play important roles in cell-to-cell communication, and exosomes from specific cell types and conditions display multiple functions such as exerting positive effects on regeneration in many tissues. It is widely accepted that the therapeutic potential of stem cells may be mediated largely by the paracrine factors, so harnessing the paracrine effects of stem and progenitor cells without affecting these living, replicating, and potentially pluripotent cell populations is an advantage in terms of safety and complexity. Ascending evidence indicated that exosomes might be the main components of paracrine factors; thus, understanding the role of exosomes in each subtype of stem cells is far-reaching. In this review, we discuss the functions of exosomes from different types of stem cells and emphasize the therapeutic potentials of exosomes, providing an alternative way of developing strategies to cure diseases
New Perspectives on Roles of Alpha-Synuclein in Parkinsonās Disease
Parkinsonās disease (PD) is one of the synucleinopathies spectrum of disorders typified by the presence of intraneuronal protein inclusions. It is primarily composed of misfolded and aggregated forms of alpha-synuclein (Ī±-syn), the toxicity of which has been attributed to the transition from an Ī±-helical conformation to a Ī²-sheetrich structure that polymerizes to form toxic oligomers. This could spread and initiate the formation of āLB-like aggregates,ā by transcellular mechanisms with seeding and subsequent permissive templating. This hypothesis postulates that Ī±-syn is a prion-like pathological agent and responsible for the progression of Parkinsonās pathology. Moreover, the involvement of the inflammatory response in PD pathogenesis has been reported on the excessive microglial activation and production of pro-inflammatory cytokines. At last, we describe several treatment approaches that target the pathogenic Ī±-syn protein, especially the oligomers, which are currently being tested in advanced animal experiments or are already in clinical trials. However, there are current challenges with therapies that target Ī±-syn, for example, difficulties in identifying varying Ī±-syn conformations within different individuals as well as both the cost and need of long-duration large trials
Neonatal outcome in 29 pregnant women with COVID-19 : A retrospective study in Wuhan, China
Funding: YTW: National Key Research and Development Program of China (2018YFC1002804), http://www.most.gov.cn; YTW: National Key Research and Development Program of China (2016YFC1000203), http://www.most.gov.cn. CL: COVID-19 Prevention and Control Program of International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University (2020-COVID-19-04), https://www.ipmch.com.cn. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Data Availability: All the research data are available at the ResMen Manager of Chinese Clinical Trial Registry (www.medresman.org), and the registration number is ChiCTR2000031954 (http://www.medresman.org.cn/pub/cn/proj/projectshshow.aspx?proj=1810).Peer reviewedPublisher PD
Defining the Genetic Features of O-Antigen Biosynthesis Gene Cluster and Performance of an O-Antigen Serotyping Scheme for Escherichia albertii
Escherichia albertii is a newly described and emerging diarrheagenic pathogen responsible for outbreaks of gastroenteritis. Serotyping plays an important role in diagnosis and epidemiological studies for pathogens of public health importance. The diversity of O-antigen biosynthesis gene clusters (O-AGCs) provides the primary basis for serotyping. However, little is known about the distribution and diversity of O-AGCs of E. albertii strains. Here, we presented a complete sequence set for the O-AGCs from 52 E. albertii strains and identified seven distinct O-AGCs. Six of these were also found in 15 genomes of E. albertii strains deposited in the public database. Possession of wzy/wzx genes in each O-AGC strongly suggest that O-antigens of E. albertii were synthesized by the Wzx/Wzy-dependent pathway. Furthermore, we performed an O-antigen serotyping scheme for E. albertii based on specific antisera against seven O-antigens and a high throughput xTAG Luminex assay to simultaneously detect seven O-AGCs. Both methods accurately identified serotypes of 64 tested E. albertii strains. Our data revealed the high-level diversity of O-AGCs in E. albertii. We also provide valuable methods to reliably identify and serotype this bacterium
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