Efficient Estimation of the Nonparametric Mean and Covariance Functions for Longitudinal and Sparse Functional Data

<p>We consider the estimation of mean and covariance functions for longitudinal and sparse functional data by using the full quasi-likelihood coupling a modification of the local kernel smoothing method. The proposed estimators are shown to be consistent, asymptotically normal, and semiparametrically <i>efficient</i> in terms of their linear functionals. Their superiority to the competitors is further illustrated numerically through simulation studies. The method is applied to analyze AIDS study and atmospheric study. Supplementary materials for this article are available online.</p

Multicomponent Approach in the Synthesis of 2,2,6-Trisubstituted Morpholine Derivatives

An efficient synthesis of 2,2,6-trisubstituted morpholine is described which involves a multicomponent process by simply mixing epichlorohydrin, <i>N</i>-bromosuccinimide, nosyl amide, and an olefin. The products contain chloride handles which are suitable for further modification

Security Analysts, Cash Flow Forecasts, and Turnover

We examine the relation between security analyst turnover and the relative accuracy of their annual earnings and cash flow forecasts. Controlling for self-selection in an analyst’s decision to issue a cash flow forecast, we find that relatively more accurate earnings and cash flow forecasts reduce the probability of turnover. Relative earnings forecast accuracy decreases the probability of turnover more than relative cash flow forecast accuracy. We conduct two cross-sectional tests. We find that relative cash flow forecast accuracy is more important in the analyst’s career outcome when cash flow forecasts are potentially more useful to investors. We find that relative cash flow forecast accuracy is more heavily weighted in the career outcome when the number of other analysts providing cash flow forecasts for the firm is larger. This finding is consistent with economic intuition that relative performance evaluation is more effective when larger groups of individuals are compared

<i>N</i>-Bromosuccinimide Promoted One-Pot Synthesis of Guanidine: Scope and Mechanism

A novel electrophilic one-pot guanidine synthesis has been developed using an olefin, a cyanimide, an amine, and <i>N</i>-bromosuccinimide. A number of guanidine derivatives were prepared with good to excellent yields. An rTRTVI precursor was also prepared based on this useful process

DataSheet_1_CAPRIN2 upregulation by LINC00941 promotes nasopharyngeal carcinoma ferroptosis resistance and metastatic colonization through HMGCR.pdf

Distant metastasis is the main cause of death in nasopharyngeal carcinoma (NPC) patients. There is an urgent need to reveal the underlying mechanism of NPC metastasis and identify novel therapeutic targets. The ferroptosis resistance and survival ability of extracellular matrix (ECM)-detached tumor cells are important factors in determining the success of distant metastasis. In this study, we found that CAPRIN2 contributes to the ferroptosis resistance and survival of ECM-detached NPC cells. Moreover, CAPRIN2 serves as a positive regulator of NPC cell migration and invasion. HMGCR, the key metabolic enzyme of the mevalonate pathway, was identified as the key downstream molecule of CAPRIN2, which mediates its regulation of ferroptosis, survival, migration and invasion of NPC cells. Lung colonization experiments showed that downregulation of the CAPRIN2/HMGCR axis resulted in reduced lung metastasis of NPC cells. Erastin treatment inhibited the ability of NPC cells to colonize the lungs, which was further enhanced by CAPRIN2/HMGCR axis downregulation. Regulated by upstream LINC00941, CAPRIN2 is abnormally activated in NPC, and its high expression is associated with a poor prognosis. In conclusion, CAPRIN2 is a molecular marker of a poor prognosis in NPC, and the LINC00941/CAPRIN2/HMGCR axis provides a new target for the treatment of NPC metastasis and ferroptosis resistance.</p

<i>N</i>‑Heterocyclic Carbene Catalyzed Sulfenylation of α,β-Unsaturated Aldehydes

An efficient <i>N</i>-heterocyclic carbene (NHC) catalyzed sulfenylation reaction of α,β-unsaturated aldehydes with <i>N</i>-(arylthio)­phthalimide has been developed. A wide variety of α-thioenals can be obtained with good to excellent yields and excellent <i>Z</i>-configuration

An Enantioselective Approach toward 3,4-Dihydroisocoumarin through the Bromocyclization of Styrene-type Carboxylic Acids

A facile and enantioselective approach toward 3,4-dihydroisocoumarin was developed. The method involved an amino-thiocarbamate catalyzed enantioselective bromocyclization of styrene-type carboxylic acids, yielding 3-bromo-3,4-dihydroisocoumarins with good yields and ee's. 3-Bromo-3,4-dihydroisocoumarins are versatile building blocks for various dihydroisocoumarin derivatives in which the Br group can readily be modified to achieve biologically important 4-O-type and 4-N-type 3,4-dihydroisocoumarin systems. In addition, studies indicated that, by refining some parameters, the synthetically useful 5-exo phthalide products could be achieved with good yields and ee's

<i>N</i>‑Heterocyclic Carbene Catalyzed Sulfenylation of α,β-Unsaturated Aldehydes

An efficient <i>N</i>-heterocyclic carbene (NHC) catalyzed sulfenylation reaction of α,β-unsaturated aldehydes with <i>N</i>-(arylthio)­phthalimide has been developed. A wide variety of α-thioenals can be obtained with good to excellent yields and excellent <i>Z</i>-configuration

Supplementary document for Improving the mechanical cooling by using magnetic thermal noise in a cavity-magnomechanical system - 6195688.pdf

supplemental documen

Revealing Solid–Liquid Equilibrium Behavior of 4‑Fluorobenzoic Acid in 12 Pure Solvents from 283.15 to 323.15 K by Experiments and Molecular Simulations

The solubility of 4-fluorobenzoic acid (4FBA) in 12 pure solvents (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, isobutanol, 1-pentanol, ethyl formate, methyl acetate, ethyl acetate, acetonitrile, and acetone) from 283.15 to 323.15 K at atmospheric pressure was determined using the gravimetric method. Within the experimental temperature range, the solubility of 4FBA increased with increasing temperature in all solvents. Four thermodynamic models (modified Apelblat model, NRTL model, Van’t Hoff model, and λh model) were selected to correlate the experimental solubility data of 4FBA and assess the goodness of fit. The results revealed that the modified Apelblat equation exhibited the highest fitting accuracy. Furthermore, the mixing thermodynamic properties (mixing Gibbs free energy, mixing enthalpy, and mixing entropy) derived from the NRTL equation indicated that the mixing process of 4FBA in the selected solvents is spontaneous and entropy-driven. To elucidate the solid–liquid equilibrium behavior of 4FBA in pure solvents, the structural properties of the solute–solvent molecules were investigated. The physicochemical properties of solvents, solvation free energies, and radial distribution functions were studied to explain the solid–liquid equilibrium behavior of 4FBA