Robust autoresonant excitation in the plasma beat-wave accelerator: a theoretical study

A modified version of the Plasma Beat-Wave Accelerator scheme is introduced and analyzed, which is based on autoresonant phase-locking of the nonlinear Langmuir wave to the slowly chirped beat frequency of the driving lasers via adiabatic passage through resonance. This new scheme is designed to overcome some of the well-known limitations of previous approaches, namely relativistic detuning and nonlinear modulation or other non-uniformity or non-stationarity in the driven Langmuir wave amplitude, and sensitivity to frequency mismatch due to measurement uncertainties and density fluctuations and inhomogeneities

A survey of HC_3N in extragalactic sources: Is HC_3N a tracer of activity in ULIRGs?

Context. HC_3N is a molecule that is mainly associated with Galactic star-forming regions, but it has also been detected in extragalactic environments. Aims. To present the first extragalactic survey of HC_3N, when combining earlier data from the literature with six new single-dish detections, and to compare HC_3N with other molecular tracers (HCN, HNC), as well as other properties (silicate absorption strength, IR flux density ratios, C_(II) flux, and megamaser activity). Methods. We present mm IRAM 30 m, OSO 20 m, and SEST observations of HC_3N rotational lines (mainly the J = 10–9 transition) and of the J = 1–0 transitions of HCN and HNC. Our combined HC_3N data account for 13 galaxies (excluding the upper limits reported for the non-detections), while we have HCN and HNC data for more than 20 galaxies. Results. A preliminary definition “HC_3N-luminous galaxy” is made based upon the HC_3N/HCN ratio. Most (~80%) HC_3N-luminous galaxies seem to be deeply obscured galaxies and (U)LIRGs. A majority (~60% or more) of the HC3N-luminous galaxies in the sample present OH mega- or strong kilomaser activity. A possible explanation is that both HC_3N and OH megamasers need warm dust for their excitation. Alternatively, the dust that excites the OH megamaser offers protection against UV destruction of HC_3N. A high silicate absorption strength is also found in several of the HC_3N-luminous objects, which may help the HC3N to survive. Finally, we find that a high HC_3N/HCN ratio is related to a high dust temperature and a low C_(II) flux

Autonomous Duffing-Holmes Type Chaotic Oscillator

A novel DuffingHolmes type autonomous chaotic oscillator is described. In comparison with the well-known nonautonomous DuffingHolmes circuit it lacks the external periodic drive, but includes two extra linear feedback subcircuits, namely a direct positive feedback loop, and an inertial negative feedback loop. In contrast to many other autonomous chaotic oscillators, including linear unstable resonators and nonlinear damping loops, the novel circuit is based on nonlinear resonator and linear damping loop in the negative feedback. SPICE simulation and hardware experimental investigations are presented. Fairly good agreement between numerical and experimental results is observed

Self-consistent Langmuir waves in resonantly driven thermal plasmas

The longitudinal dynamics of a resonantly driven Langmuir wave are analyzed in the limit that the growth of the electrostatic wave is slow compared to the bounce frequency. Using simple physical arguments, the nonlinear distribution function is shown to be nearly gaussian in the canonical particle action, with a slowly evolving mean and fixed variance. Self-consistency with the electrostatic potential provide the basic properties of the nonlinear distribution function including a frequency shift that agrees well with driven, electrostatic particle simulations. This extends earlier work on nonlinear Langmuir waves by Morales and O'Neil [G. J. Morales and T. M. O'Neil, Phys. Rev. Lett. 28, 417 (1972)], and could form the basis of a reduced kinetic treatment of Raman backscatter in a plasma.Comment: 11 pages, 4 figures, submitted to Physics of Plasma

One step multiderivative methods for first order ordinary differential equations

A family of one-step multiderivative methods based on Padé approximants to the exponential function is developed. The methods are extrapolated and analysed for use in PECE mode. Error constants and stability intervals are calculated and the combinations compared with well known linear multi-step combinations and combinations using high accuracy Newton-Cotes quadrature formulas as correctors. w926020

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity.

Abnormal activation of the epidermal growth factor receptor (EGFR) due to a deletion of exons 2-7 of EGFR (EGFRvIII) is a common alteration in glioblastoma (GBM). While this alteration can drive gliomagenesis, tumors harboring EGFRvIII are heterogeneous. To investigate the role for EGFRvIII activation in tumor phenotype we used a neural progenitor cell-based murine model of GBM driven by EGFR signaling and generated tumor progenitor cells with high and low EGFRvIII activation, pEGFRHi and pEGFRLo. In vivo, ex vivo, and in vitro studies suggested a direct association between EGFRvIII activity and increased tumor cell proliferation, decreased tumor cell adhesion to the extracellular matrix, and altered progenitor cell phenotype. Time-lapse confocal imaging of tumor cells in brain slice cultures demonstrated blood vessel co-option by tumor cells and highlighted differences in invasive pattern. Inhibition of EGFR signaling in pEGFRHi promoted cell differentiation and increased cell-matrix adhesion. Conversely, increased EGFRvIII activation in pEGFRLo reduced cell-matrix adhesion. Our study using a murine model for GBM driven by a single genetic driver, suggests differences in EGFR activation contribute to tumor heterogeneity and aggressiveness

Notes

Notes by Benedict R. Danko, Patrick F. Coughlin, William J. O\u27Connor, John E. Lindberg, Lawrence S. May, Jr., Arthur L. Beaudette, and Mark Harry Berens