Nuevos datos acerca de los repertorios teatrales en el primer catálogo de «El peregrino en su patria»

En este artículo se muestra cómo los títulos que contienen los repertorios de los autores de comedias presentes en El peregrino en su patria de 1604 están dispuestos según un orden cronológico, aunque con algunos matices y no pocas excepciones. Además, se amplían los repertorios descubiertos por Thornton Wilder y se afina la fecha de composición de varias obras, prestando especial atención a textos que se han perdido, como La perdición de España, La gobernadora, La gran pintora, La bella gitana o La toma de Álora. Finalmente, el presente artículo pretende mostrar de un modo práctico cómo una base de datos digital como el Diccionario biográfico de actores del teatro clásico español (DICAT) puede resultar de gran ayuda a la hora de resolver algunos de los problemas clásicos de la filología en general y del teatro del Siglo de Oro en particular.This paper shows that the plays contained in the repertoire of the autores de comedias which appear in El peregrino en su patria (1604) are organised chronologically, although there are some nuances and exceptions. The article also expands the repertoire discovered by Thornton Wilder and sets the date of composition for some plays, paying special attention to lost texts such as La perdición de España, La gobernadora, La gran pintora, La bella gitana or La toma de Álora. Finally, this paper attempts to show in a practical way that a database such as the Diccionario biográfico de actores del teatro clásico español (DICAT) can be extremely helpful when it comes to dealing with some of the philology's classical problems in general and those of the theatre of the Golden Age in particular

Helically Locked Tethered Twistacenes

Twisting linear acenes out of planarity affects their electronic and optical properties, and induces chirality. However, it is difficult to isolate the effect of twisting from the substituent effect. Moreover, many twistacenes (twisted acenes) readily racemize in solution. Here, we introduce a series of twistacenes having an anthracene backbone diagonally tethered by an <i>n</i>-alkyl bridge, which induces a twist of various angles. This allows us to systematically monitor the effect of twisting on electronic and optical properties. We find that absorption is bathochromically shifted with increasing twist, while fluorescence quantum efficiency drops dramatically. The tethered twistacenes were isolated to their enantiomerically pure form, displaying strong chiroptical properties and anisotropy factor (<i>g</i>-value). No racemization was observed even upon prolonged heating, rendering these tethered twistacenes suitable as enantiopure helical building units for π-conjugated backbones

Helically Locked Tethered Twistacenes

Twisting linear acenes out of planarity affects their electronic and optical properties, and induces chirality. However, it is difficult to isolate the effect of twisting from the substituent effect. Moreover, many twistacenes (twisted acenes) readily racemize in solution. Here, we introduce a series of twistacenes having an anthracene backbone diagonally tethered by an <i>n</i>-alkyl bridge, which induces a twist of various angles. This allows us to systematically monitor the effect of twisting on electronic and optical properties. We find that absorption is bathochromically shifted with increasing twist, while fluorescence quantum efficiency drops dramatically. The tethered twistacenes were isolated to their enantiomerically pure form, displaying strong chiroptical properties and anisotropy factor (<i>g</i>-value). No racemization was observed even upon prolonged heating, rendering these tethered twistacenes suitable as enantiopure helical building units for π-conjugated backbones

Helically Locked Tethered Twistacenes

Twisting linear acenes out of planarity affects their electronic and optical properties, and induces chirality. However, it is difficult to isolate the effect of twisting from the substituent effect. Moreover, many twistacenes (twisted acenes) readily racemize in solution. Here, we introduce a series of twistacenes having an anthracene backbone diagonally tethered by an <i>n</i>-alkyl bridge, which induces a twist of various angles. This allows us to systematically monitor the effect of twisting on electronic and optical properties. We find that absorption is bathochromically shifted with increasing twist, while fluorescence quantum efficiency drops dramatically. The tethered twistacenes were isolated to their enantiomerically pure form, displaying strong chiroptical properties and anisotropy factor (<i>g</i>-value). No racemization was observed even upon prolonged heating, rendering these tethered twistacenes suitable as enantiopure helical building units for π-conjugated backbones

Helically Locked Tethered Twistacenes

Twisting linear acenes out of planarity affects their electronic and optical properties, and induces chirality. However, it is difficult to isolate the effect of twisting from the substituent effect. Moreover, many twistacenes (twisted acenes) readily racemize in solution. Here, we introduce a series of twistacenes having an anthracene backbone diagonally tethered by an <i>n</i>-alkyl bridge, which induces a twist of various angles. This allows us to systematically monitor the effect of twisting on electronic and optical properties. We find that absorption is bathochromically shifted with increasing twist, while fluorescence quantum efficiency drops dramatically. The tethered twistacenes were isolated to their enantiomerically pure form, displaying strong chiroptical properties and anisotropy factor (<i>g</i>-value). No racemization was observed even upon prolonged heating, rendering these tethered twistacenes suitable as enantiopure helical building units for π-conjugated backbones

Helically Locked Tethered Twistacenes

Twisting linear acenes out of planarity affects their electronic and optical properties, and induces chirality. However, it is difficult to isolate the effect of twisting from the substituent effect. Moreover, many twistacenes (twisted acenes) readily racemize in solution. Here, we introduce a series of twistacenes having an anthracene backbone diagonally tethered by an <i>n</i>-alkyl bridge, which induces a twist of various angles. This allows us to systematically monitor the effect of twisting on electronic and optical properties. We find that absorption is bathochromically shifted with increasing twist, while fluorescence quantum efficiency drops dramatically. The tethered twistacenes were isolated to their enantiomerically pure form, displaying strong chiroptical properties and anisotropy factor (<i>g</i>-value). No racemization was observed even upon prolonged heating, rendering these tethered twistacenes suitable as enantiopure helical building units for π-conjugated backbones

Helically Locked Tethered Twistacenes

Twisting linear acenes out of planarity affects their electronic and optical properties, and induces chirality. However, it is difficult to isolate the effect of twisting from the substituent effect. Moreover, many twistacenes (twisted acenes) readily racemize in solution. Here, we introduce a series of twistacenes having an anthracene backbone diagonally tethered by an <i>n</i>-alkyl bridge, which induces a twist of various angles. This allows us to systematically monitor the effect of twisting on electronic and optical properties. We find that absorption is bathochromically shifted with increasing twist, while fluorescence quantum efficiency drops dramatically. The tethered twistacenes were isolated to their enantiomerically pure form, displaying strong chiroptical properties and anisotropy factor (<i>g</i>-value). No racemization was observed even upon prolonged heating, rendering these tethered twistacenes suitable as enantiopure helical building units for π-conjugated backbones

Pre-implantation genetic diagnosis

Genetic disorders are a major cause of miscarriage and fetal death. Pre-implantation genetic diagnosis (PGD) can be used to diagnose genetic defects before pregnancy has occurred by creating embryos by IVF, then removing single cells which are genetically analysed using FISH or PCR. Although successful, the techniques have many difficulties because they are highly specialised and at the extreme limit of sensitivity. Newer techniques, however, can rapidly diagnose multiple defects including chromosomal aneuploidy, sex and single gene defects. Embryonic cells can also be DNA fingerprinted to ensure that contamination has not occurred. As embryo screening can increase IVF success rates and decrease miscarriage rates, it will be increasing offered in routine IVF rather than just those patients at high genetic risk. These new, low cost techniques may ultimately allow PGD to be offered to all IVF patients regardless of risk

Reactivity of Long Conjugated Systems: Selectivity of Diels–Alder Cycloaddition in Oligofurans

Taking advantage of the synthetic availability and solubility of long oligofurans, their reactivity toward dienophiles was studied as a model for the rarely investigated reactivity of long conjugated systems. Unlike oligoacenes, the reactivity of oligofurans decreases or remains constant with increasing chain length. Terminal ring cycloadducts of oligofurans are kinetically and thermodynamically favored, whereas central ring cycloadducts are preferred in oligoacenes, because of the different driving forces in the two reactions: π-conjugation in oligofurans and aromatization/dearomatization in oligoacenes

Novel Cu(I)-Selective Chelators Based on a Bis(phosphorothioyl)amide Scaffold

Bis­(dialkyl/aryl-phosphorothioyl)­amide (BPA) derivatives are versatile ligands known by their high metal-ion affinity and selectivity. Here, we synthesized related chelators based on bis­(1,3,2-dithia/dioxaphospholane-2-sulfide)­amide (BTPA/BOPA) scaffolds targeting the chelation of soft metal ions. Crystal structures of BTPA compounds <b>6</b> (N^–R₃NH⁺) and <b>8</b> (NEt) revealed a <i>gauche</i> geometry, while BOPA compound <b>7</b> (N^–R₃NH⁺) exhibited an <i>anti</i>-geometry. Solid-state ³¹P magic-angle spinning NMR spectra of BTPA <b>6</b>-Hg­(II) and <b>6</b>-Zn­(II) complexes imply a square planar or tetrahedral geometry of the former and a distorted tetrahedral geometry of the latter, while both BTPA <b>6</b>-Ni­(II) and BOPA <b>7</b>-Ni­(II) complexes possibly form a polymeric structure. In Cu­(I)-H₂O₂ system (Fenton reaction conditions) BTPA compounds <b>6</b>, <b>8</b>, and <b>10</b> (NCH₂Ph) were identified as most potent antioxidants (IC₅₀ 32, 56, and 29 μM, respectively), whereas BOPA analogues <b>7</b>, <b>9</b> (NEt), and <b>11</b> (NCH₂Ph) were found to be poor antioxidants. In Fe­(II)-H₂O₂ system, IC₅₀ values for both BTPA and BOPA compounds exceeded 500 μM indicating high selectivity to Cu­(I) versus the borderline Fe­(II)-ion. Neither BTPA nor BOPA derivatives showed radical scavenging properties in H₂O₂ photolysis, implying that inhibition of the Cu­(I)-induced Fenton reaction by both BTPA and BOPA analogues occurred predominantly through Cu­(I)-chelation. In addition, NMR-monitored Cu­(I)- and Zn­(II)-titration of BTPA compounds <b>8</b> and <b>10</b> showed their high selectivity to a soft metal ion, Cu­(I), as compared to a borderline metal ion, Zn­(II). In summary, lipophilic BTPA analogues are promising highly selective Cu­(I) ion chelators