Supergravity loop contributions to brane world supersymmetry breaking

We compute the supergravity loop contributions to the visible sector scalar masses in the simplest 5D `brane-world' model. Supersymmetry is assumed to be broken away from the visible brane and the contributions are UV finite due to 5D locality. We perform the calculation with N = 1 supergraphs, using a formulation of 5D supergravity in terms of N = 1 superfields. We compute contributions to the 4D effective action that determine the visible scalar masses, and we find that the mass-squared terms are negative.Comment: 12 pages, LaTeX 2

Mediation of supersymmetry breaking in extra dimensions

We review the mechanisms of supersymmetry breaking mediation that occur in sequestered models, where the visible and the hidden sectors are separated by an extra dimension and communicate only via gravitational interactions. By locality, soft breaking terms are forbidden at the classical level and reliably computable within an effective field theory approach at the quantum level. We present a self-contained discussion of these radiative gravitational effects and the resulting pattern of soft masses, and give an overview of realistic model building based on this set-up. We consider both flat and warped extra dimensions, as well as the possibility that there be localized kinetic terms for the gravitational fields.Comment: LaTex, 15 pages; brief review prepared for MPLA. v2: minor correction

Six-dimensional Supergravity and Projective Superfields

We propose a superspace formulation of N=(1,0) conformal supergravity in six dimensions. The corresponding superspace constraints are invariant under super-Weyl transformations generated by a real scalar parameter. The known variant Weyl super-multiplet is recovered by coupling the geometry to a super-3-form tensor multiplet. Isotwistor variables are introduced and used to define projective superfields. We formulate a locally supersymmetric and super-Weyl invariant action principle in projective superspace. Some families of dynamical supergravity-matter systems are presented.Comment: 39 pages; v3: some modifications in section 2; equations (2.3), (2.14b), (2.16) and (2.17) correcte

Effective Symmetries of the Minimal Supermultiplet of N = 8 Extended Worldline Supersymmetry

A minimal representation of the N = 8 extended worldline supersymmetry, known as the `ultra-multiplet', is closely related to a family of supermultiplets with the same, E(8) chromotopology. We catalogue their effective symmetries and find a Spin(4) x Z(2) subgroup common to them all, which explains the particular basis used in the original construction. We specify a constrained superfield representation of the supermultiplets in the ultra-multiplet family, and show that such a superfield representation in fact exists for all adinkraic supermultiplets. We also exhibit the correspondences between these supermultiplets, their Adinkras and the E(8) root lattice bases. Finally, we construct quadratic Lagrangians that provide the standard kinetic terms and afford a mixing of an even number of such supermultiplets controlled by a coupling to an external 2-form of fluxes.Comment: 13 Figure

Algebra of Lax Connection for T-Dual Models

We study relation between T-duality and integrability. We develop the Hamiltonian formalism for principal chiral model on general group manifold and on its T-dual image. We calculate the Poisson bracket of Lax connections in T-dual model and we show that they are non-local as opposite to the Poisson brackets of Lax connection in original model. We demonstrate these calculations on two specific examples: Sigma model on S(2) and sigma model on AdS(2).Comment: 24 pages, references adde

Five dimensional supergravity in N = 1 superspace

We give a formulation of linearized minimal 5-dimensional supergravity in N = 1 superspace. Infinitesimal local 5D diffeomorphisms, local 5D Lorentz transformations, and local 5D supersymmetry are all realized as off-shell superfield transformations. Compactification on an S^1 / Z_2 orbifold and couplings to brane-localized supermultiplets are very simple in this formalism. We use this to show that 5-dimensional supergravity can naturally generate mu and B mu terms of the correct size in gaugino- or radion-mediated supersymmetry breaking. We also include a self-contained review of linearized minimal 4D supergravity in superspace.Comment: 22 pages, LaTeX2e, no figure

Superfield description of gravitational couplings in generic 5D supergravity

We complete the N=1 superfield action for the generic system of vector multiplets and hypermultiplets coupled to 5D supergravity, which is based on the superconformal formulation. Especially we clarify the gravitational couplings to the bulk matters at linear order in the gravitational superfields. They consist of four N=1 superfields, two of which are Z_2-odd when the fifth dimension is compactified on S^1/Z_2. This formulation provides a powerful tool to calculate quantum effects, keeping the N=1 off-shell structure.Comment: 36 pages, typos correcte

Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10-8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10-10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA)

Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

\ua9 2021, The Author(s).Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 7 10−8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 7 10−10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA)

Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10^{-8}; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10^{−10}; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA)