catena-Poly[[[triaqua­manganese(II)]-μ-4,4′-bipyridine-κ2 N:N′-[triaqua­manganese(II)]-μ-pyrimidine-4,6-dicarboxyl­ato-κ4 N 1,O 6:N 3,O 4] sulfate trihydrate]

The two independent MnII ions in the polymeric title compound, {[Mn2(C6H2N2O4)(C10H8N2)(H2O)6]SO4·3H2O}, exhibit distorted MnN2O4 octa­hedral coordination geometries, with the pyrimidine-4,6-dicarboxyl­ate (pmdc) ligand acting in the bis-chelating μ-(κO,κN:κO′,κN′) bridging mode and the 4,4′-bipyridine (bpy) ligand in the μ-(κN:κN′) bridging mode. The remaining coordination sites are occupied by O atoms of water mol­ecules. As a consequence, cationic chains of [Mn2(μ-pmdc)(μ-4,4′-bpy)(H2O)6]2+ are generated, which extend approximately along the a axis. Sulfate counter-anions and three uncoordinated water mol­ecules complete the structure, which is stabilized by multiple O—H⋯O hydrogen-bonding inter­actions between the structural units

Endocrine disruption in Crohn’s disease: Bisphenol A enhances systemic inflammatory response in patients with gut barrier translocation of dysbiotic microbiota products

This study has been partially funded by PID2019-107036RB-I00, from Ministerio de Ciencia, Innovacion y Universidades, Madrid, Spain, and 2020-0287, from IIS ISABIAL, Hospital General Universitario, Alicante, Spain. RL is recipient of a grant (FPU 18/00063) by Ministerio de Ciencia, Innovacion y Universidades, Madrid, Spain.The relevance of environmental triggers in Crohn's disease remains poorly explored, despite the well-known association between industrialization and disease onset/progression. We have aimed at evaluating the influence of endocrine disrupting chemicals in CD patients. We performed a prospective observational study on consecutive patients diagnosed of CD. Serum levels of endocrine disruptors, short-chain fatty acids, tryptophan and cytokines were measured. Bacterial-DNA and serum endotoxin levels were also evaluated. Gene expression of ER-α, ER-β and GPER was measured in PBMCs. All patients were genotyped for NOD2 and ATG16L1 polymorphisms. A series of 200 CD patients (140 in remission, 60 with active disease) was included in the study. Bisphenol A was significantly higher in patients with active disease versus remission and in colonic versus ileal disease. GPER was significantly increased in active patients and correlated with BPA levels. BPA was significantly increased in patients with bacterial-DNA and correlated with serum endotoxin levels, (r = 0.417; P = .003). Serum butyrate and tryptophan levels were significantly lower in patients with bacterial-DNA and an inverse relationship was present between them and BPA levels (r = −0.491; P = .001) (r = −0.611; P = .001). Serum BPA levels correlated with IL-23 (r = 0.807; P = .001) and IL-17A (r = 0.743; P = .001). The multivariate analysis revealed an independent significant contribution of BPA and bacterial-DNA to serum levels of IL-23 and IL-17A. In conclusion, bisphenol A significantly affects systemic inflammatory response in CD patients with gut barrier disruption and dysbiotic microbiota secretory products in blood. These results provide evidence of an endocrine disruptor playing an actual pathogenic role on CD.Ministerio de Ciencia, Innovacion y Universidades, Madrid, Spain PID2019-107036RB-I00 FPU 18/00063IIS ISABIAL, Hospital General Universitario, Alicante, Spain 2020-028

Self-Efficacy and Emotional Intelligence as Predictors of Perceived Stress in Nursing Professionals

Background: Nursing professionals face a variety of stressful situations daily, where the patients’ own stresses and the demands of their family members are the most important sources of such stress. Methods: The main objectives pursued were to describe the relationships of self-efficacy and emotional intelligence with perceived stress in a sample of nursing professionals. We also developed predictive models for each of the components of perceived stress based on the dimensions of emotional intelligence and self-efficacy, for the total sample, as well as samples differentiated by sex. This study sample consisted of 1777 nurses and was conducted using multiple scales: the perceived stress questionnaire, general self-efficacy scale, and the brief emotional intelligence survey for senior citizens. Results: The variables stress management, mood, adaptability, intrapersonal skills, and self-efficacy explained 22.7% of the variance in the harassment–social component, while these same variables explained 28.9% of the variance in the irritability–tension–fatigue dimension. The variables mood, stress management, self-efficacy, intrapersonal, and interpersonal explained 38.6% of the variance in the energy–joy component, of which the last variable offers the most explanatory capacity. Finally, the variables stress management, mood, interpersonal, self-efficacy and intrapersonal skills explained 27.2% of the variance in the fear–anxiety dimension. Conclusion: The results of this study suggest that one way to reduce stress in professionals would be to help them improve their emotional intelligence in programs (tailored to consider particularities of either sex) within the framework of nursing, enabling them to develop and acquire more effective stress coping strategies, which would alleviate distress and increase the wellbeing of health professionals

Sleep Quality and the Mediating Role of Stress Management on Eating by Nursing Personnel

Background: The work schedule of nursing personnel often involves double or continuous shifts and sources of stress derived from the work context, making it necessary to ensure their rest and eating habits contribute to a healthy lifestyle. The objective of this study was to analyze the mediating role of stress management on the effect that sleep quality has on uncontrolled and emotional eating by nursing professionals. The Three-Factor Eating Questionnaire-R18 was applied to measure uncontrolled and emotional eating, the Pittsburgh Sleep Quality Index as a measure of sleep quality, and the EQ-i-20M for the stress management component of emotional intelligence. (2) Methods: A sample of 1073 nurses aged 22 to 57 years was selected for this purpose. (3) Results: The main result of this study was that stress management was a mediator in the effect of sleep quality on uncontrolled and emotional eating. Furthermore, low scores for sleeping problems correlated with high scores for stress management. The results also revealed a strong negative association between stress management and uncontrolled and emotional eating. (4) Conclusions: The results are discussed from the perspective of promoting health at work as well as improving the psychosocial wellbeing of nursing professionals and increasing the quality of patient care

Self-Expressive Creativity in the Adolescent Digital Domain: Personality, Self-Esteem, and Emotions

Background: Although self-expressive creativity is related to cyberbullying, it can also reinforce strengths that contribute to positive adolescent development. Our study concentrated on the relationships between personality traits and self-expressive creativity in the digital domain in an adolescent population. For this, we analyzed the effect of self-esteem and emotional intelligence as assets for positive development related to personality traits and self-expressive creativity. Methods: The study population included a total of 742 adolescents that were high-school students in the province of Almería, Spain. The following instruments were used: Big Five Inventory (BFI) to evaluate the five broad personality factors, Rosenberg Self-Esteem Scale (RSE), Expression, Management, and Emotion Recognition Evaluation Scale (TMMS-24), and the Creative Behavior Questionnaire: Digital (CBQD). Results: The cluster analysis revealed the existence of two profiles of adolescents based on their personality traits. The analysis showed that the group with the highest levels of extraversion and openness to experience and lowest levels of neuroticism were those who showed the highest scores in self-esteem, clarity, and emotional repair, as well as in self-expressive creativity. Higher scores in neuroticism and lower scores in extraversion and openness to experience showed a direct negative effect on self-expressive creativity and indirect effect through self-esteem and emotional attention, which acted as mediators in series. Conclusions: To counteract certain characteristics that increase adolescents’ vulnerability to social network bullying, a plan must be developed for adequate positive use of the Internet from a creative model that enables digital self-expression for acquiring identity and self-efficacy through the positive influence of peers, which promotes feelings of empowerment and self-affirmation through constructive tasks that reinforce self-esteem and emotional intelligence

La Responsabilidad Penal y Civil en el Homicidio y Lesiones Culposas resultantes de un accidente de Transito Terrestre

Sedesarrolló el procedimiento a seguir en el caso de los homicidios y lesiones culposas resultantes de un accidente de tránsito terrestre, amparado bajo la Normativa Jurídica previamente establecida denominada Ley de Procedimientos Especiales sobre Accidentes de Tránsito para el tema de investigació

The argonaut constructs its shell via physical self-organization and coordinated cell sensorial activity.

We acknowledge TESCAN and Carl Zeiss Microscopy GmbH for the acquisition and early processing of the images by FIB-SEM. This research was funded by projects CGL2017-85118-P (A.G.C., C.G.), PID2020- 116660GB-I00 (A.G.C., C.G., A.B.R.-N.) (Spanish Ministerio de Ciencia e Innovación), and B-RNM-265- UGR18 (A.G.C., C.G., A.B.R.-N.) (Junta de Andalucía), the Unidad Científica de Excelencia UCE-PP2016-05 (A.G.C., C.G., A.B.R.-N.) (University of Granada), and the Research Group RNM363 (A.G.C., C.G.) (Junta de Andalucía).Conceptualization: A.G.C.; methodology: A.G.C., F.L., A.B.R.-N., and E.G.; investigation and formal analysis: all authors; visualization: A.G.C., F.L.; writing – original draft: A.G.C.; writing – review & editing: F.L., C.G., E.G., A.B.R.-N., W.W.S.The shell of the cephalopod Argonauta consists of two layers of fibers that elongate perpendicular to the shell surfaces. Fibers have a high-Mg calcitic core sheathed by thin organic membranes (>100 nm) and configurate a polygonal network in cross section. Their evolution has been studied by serial sectioning with electron microscopy-associated techniques. During growth, fibers with small cross-sectional areas shrink, whereas those with large sections widen. It is proposed that fibers evolve as an emulsion between the fluid precursors of both the mineral and organic phases. When polygons reach big cross-sectional areas, they become subdivided by new membranes. To explain both the continuation of the pattern and the subdivision process, the living cells from the mineralizing tissue must perform contact recognition of the previously formed pattern and subsequent secretion at sub-micron scale. Accordingly, the fabrication of the argonaut shell proceeds by physical self-organization together with direct cellular activity.Unidad Científica de Excelencia UCE-PP2016-05Ministerio de Ciencia e Innovación B-RNM-265-UGR18Universidad de Granada RNM363Junta de Andalucí

Evaluación del funcionamiento, operación y mantenimiento de la infraestructura sanitaria en las instituciones educativas de la ciudad de Cajamarca, 2016

RESUMEN La presente investigación está orientada a evaluar el funcionamiento, operación y mantenimiento de la infraestructura sanitaria en las instituciones educativas del nivel secundario de la ciudad de Cajamarca. Esta investigación busca dar a conocer en qué condiciones se encuentra la infraestructura sanitaria en las instituciones educativas de Cajamarca, dando recomendaciones y propuestas de mejora para lograr un buen funcionamiento de las instalaciones y así disminuir el consumo de agua y mantener un ambiente confortable para la familia institucional. Los indicadores considerados en esta investigación son el estado actual de la infraestructura sanitaria, la operación y el manteamiento de la misma; iniciando la evaluación desde la acometida de la red pública hasta el punto de descarga. Por medio de formatos de recolección de datos se determinó el estado actual de la infraestructura y se verificó si las instituciones educativas cuentan con el personal adecuado para realizar la operación y el mantenimiento. Los resultados obtenidos permiten afirmar que el funcionamiento, la operación y el mantenimiento se encuentran en un estado regular, teniendo como porcentaje final 51.95%, según la valoración y metodología empleadas.ABSTRACT This research is aimed at evaluating the performance, operation and maintenance of the health infrastructure in educational institutions at the secondary level of the city of Cajamarca. This research seeks to publicize what conditions is the health infrastructure in educational institutions of Cajamarca, giving recommendations and suggestions for improvement to achieve a smooth functioning of facilities and thus reduce water consumption and maintain a comfortable environment for family institutional. The indicators used in this research are the current state of the health infrastructure, operation and blanketing thereof; beginning with the assessment from the onslaught of the public network to the point of discharge. Through data collection formats the current state of infrastructure was determined and verified whether the educational institutions have adequate staff to perform operation and maintenance. The results confirm that the operation, operation and maintenance are in a steady state, with the final percentage 51.95%, according to the assessment and methodology employed