Compaction dynamics in ductile granular media

Ductile compaction is common in many natural systems, but the temporal evolution of such systems is rarely studied. We observe surprising oscillations in the weight measured at the bottom of a self-compacting ensemble of ductile grains. The oscillations develop during the first ten hours of the experiment, and usually persist through the length of an experiment (one week). The weight oscillations are connected to the grain--wall contacts, and are directly correlated with the observed strain evolution and the dynamics of grain--wall contacts during the compaction. Here, we present the experimental results and characteristic time constants of the system, and discuss possible reasons for the measured weight oscillations.Comment: 11 pages, 14 figure

Epigenetics: A novel therapeutic approach for the treatment of Alzheimer\u27s disease

Alzheimer\u27s disease (AD) is the most common type of dementia in the elderly. It is characterized by the deposition of two forms of aggregates within the brain, the amyloid β plaques and tau neurofibrillary tangles. Currently, no disease-modifying agent is approved for the treatment of AD. Approved pharmacotherapies target the peripheral symptoms but they do not prevent or slow down the progression of the disease. Although several disease-modifying immunotherapeutic agents are in clinical development, many have failed due to the lack of efficacy or serious adverse events. Epigenetic changes including DNA methylation and histone modifications are involved in learning and memory and have been recently highlighted for holding promise as potential targets for AD therapeutics. Dynamic and latent epigenetic alterations are incorporated in AD pathological pathways and present valuable reversible targets for AD and other neurological disorders. The approval of epigenetic drugs for cancer treatment has opened the door for the development of epigenetic drugs for other disorders including neurodegenerative diseases. In particular, methyl donors and histone deacetylase inhibitors are being investigated for possible therapeutic effects to rescue memory and cognitive decline found in such disorders. This review explores the area of epigenetics for potential AD interventions and presents the most recent findings in this field

Efektivitas Komunikasi Dalam Organisasi

The need of communication in today’s business competition is continually changing. The advancement of information technology and the changing in managing organization has altered the way that many organizations communicate. The information technology is a tool to communicate with many different groups. The communication process should be managed effectively since not all managers and individu in an organization have good communication skills abd there is an obvious need for training to ensure that they are able to choose the most appropriate communication method to get the message across clearly understood by the receiver and on the other hand, the receiver should be able to supply some feedback

Studi Kelayakan Pembangunan Fly Over Jalan Akses Pelabuhan Teluk Lamong Ditinjau dari Segi Lalu Lintas dan Ekonomi Jalan Raya

- Pelabuhan Teluk Lamong adalah proyek PT. Pelindo III sebagai sarana penunjang Pelabuhan Tanjung Perak yang terletak sekitar 2 km dari pantai Teluk Lamong. Pelabuhan ini berfungsi sebagai pelabuhan barang yang nantinya akan disinggahi oleh kapal – kapal besar dengan kapasitas maksimum 35.000 DWT. Dengan kapasitas sebesar itu tentu akan membuat Pelabuhan Teluk Lamong mempunyai lalu lintas keluar masuk truk ekspedisi yang tinggi sehingga dapat membuat kemacetan di jalan sekitarnya. Tugas Akhir ini akan menganalisis kelayakan dari pembangunan fly over di Jalan Akses Pelabuhan Teluk Lamong yang ditinjau dari segi lalu lintas dan ekonomi jalan raya. Analisis yang akan dihitung antara lain analisis tingkat kinerja jalan berupa Derajat Kejenuhan (DS), analisis perhitungan penghematan nilai waktu dan Biaya Operasional Kendaraan (BOK), analisis Benefit Cost Ratio (BCR) dan analisis Net Present Value (NPV). Dalam Tugas Akhir ini pada kondisi eksisting tahun 2014 nilai DS = 0,633 < 1 untuk arah Surabaya – Gresik dan DS = 0,991 arah sebaliknya, maka kinerja jalan sudah hampir tidak berfungsi dengan baik. Jika dilihat dari hasil perhitungan KAJI maka dapat disimpulkan bahwa pembangunan fly over Jalan Akses Pelabuhan Teluk Lamong layak dari segi lalu lintas, karena dengan adanya fly over nilai DS berkurang yaitu pada tahun 2034 untuk arah keluar pelabuhan DS = 0,267 dan arah sebaliknya DS = 0,371. Adapun analisis kelayakan fly over secara ekonomi akan ditentukan berdasarkan nilai rasio benefit dan cost. Benefit yang dihitung adalah penghematan BOK dan nilai waktu, nilai BOK dihitung berdasarkan metode Jasa Marga. Didapat nilai BCR = 2,87 > 1 dan NPV = Rp 1.402.399.817.323 > 0 hal ini menunjukkan proyek memenuhi syarat kelayakan secara ekonomi

Design and analysis of multiband circular microstrip patch antenna for wireless communication

The study proposes a novel Approach of Circular Microstrip Patch Antenna for Multi-Band. The Proposed Antenna Dimension is (40×30×1.6)mm^3 on the FR-4, Which has ε_r equals(4.3) and Loss tangent (0.002). Both Patches and Grounds are Copper Material With Thickness (0.035 mm) Five Bands are Achieved, At Resonance Frequencies (9.658 GHz), (11.68 GHz), (16.054 GHz), (21.28 GHz), and (29.704 GHz) Respectively. This Antenna Operates In Wireless Applications for Operation in The X-Band, Ku-Band, Ka-Band, K-Band, and 5G. Also it is Works for Radar, Satellite Communications, Wireless Network Computer, Medical Communication Devices, and Local Multi Point TV, to Detect Vehicles Speeding, Especially in Europe Vehicles Speeding, Especially in Europe. The Proposed Antenna is Effectively Manufactured and Checked Using a Vector Network Analyzer (VNA) and is Simulation Using CST-MW Software version 2019