TripleRE: Knowledge Graph Embeddings via Tripled Relation Vectors

Translation-based knowledge graph embedding has been one of the most important branches for knowledge representation learning since TransE came out. Although many translation-based approaches have achieved some progress in recent years, the performance was still unsatisfactory. This paper proposes a novel knowledge graph embedding method named TripleRE with two versions. The first version of TripleRE creatively divide the relationship vector into three parts. The second version takes advantage of the concept of residual and achieves better performance. In addition, attempts on using NodePiece to encode entities achieved promising results in reducing the parametric size, and solved the problems of scalability. Experiments show that our approach achieved state-of-the-art performance on the large-scale knowledge graph dataset, and competitive performance on other datasets

Efficient scheme for three-photon Greenberger-Horne-Zeilinger state generation

We propose an efficient scheme for the generation of three-photon Greenberger-Horne-Zeilinger (GHZ) state with linear optics and postselection. Several devices are designed and a two-mode quantum nondemolition (QND) detection is introduced to obtain the desired state. It is worth noting that the states which have entanglement in both polarization and spatial degrees of freedom are created in one of the designed setups. The method described in the present scheme can create a large number of three-photon GHZ states in principle. We also discuss an approach to generate the desired GHZ state in the presence of channel noise.Comment: 7pages, 3 figure

Asymptotic Analytical Solutions of First-Passage Rate to Quasi- Nonintegrable Hamiltonian Systems

The first-passage problem of quasi-nonintegrable Hamiltonian systems subject to light linear/nonlinear dampings and weak external/parametric random excitations is investigated here. The motivation is to acquire asymptotic analytical solution of the firstpassage rate or the mean first-passage time based on the averaged Itô stochastic differential equation for quasi-nonintegrable Hamiltonian systems. By using the probability current equation and the Laplace integral method, a new method is proposed to obtain the asymptotic analytical expressions for the first-passage rate in the case of high passage threshold. The associated functions such as the reliability function and the probability density function of first-passage time can then be obtained from the first-passage rate. High passage threshold is the crucial condition for the validity of the proposed method. The random bistable oscillator is studied as an illustrative example using the method. The analytical result obtained from the asymptotic analysis shows its consistency with the Kramers formula. A coupled two-degree-of-freedom (2DOF) nonlinear oscillator subjected to stochastic excitations is studied to illustrate the procedure of acquiring the asymptotic analytical solution. The results obtained from the analytical solution agree well with those from numerical simulation, which verifies the accuracy of the proposed method

Uplift, Climate and Biotic Changes at the Eocene-Oligocene Transition in Southeast Tibet

The uplift history of southeastern Tibet is crucial to understanding processes driving the tectonic evolution of the Tibetan Plateau and surrounding areas. Underpinning existing palaeoaltimetric studies has been regional mapping based in large part on biostratigraphy that assumes a Neogene modernisation of the highly diverse, but threatened, Asian biota. Here, with new radiometric dating and newly-collected plant fossil archives, we quantify the surface height of part of Tibet’s southeastern margin of Tibet in the latest Eocene (~34 Ma) to be ~3 km and rising, possibly attaining its present elevation (3.9 km) in the early Oligocene. We also find that the Eocene-Oligocene transition in southeastern Tibet witnessed leaf size diminution and a floral composition change from sub-tropical/warm temperate to cool temperate, likely reflective of both uplift and secular climate change, and that by the latest Eocene floral modernization on Tibet had already taken place implying modernization was deeply-rooted in the Paleogene

Cloning and characterization of functional keratinassociated protein 5-4 gene in maize

Keratin-associated proteins (KAPs) 5-4 which belongs to keratin-associated protein (KRTAP) type 5 family has two major groups: high/ultrahigh cysteine (HS) and high glycine-tyrosine (HGT). Based on bioinformatic prediction, we experimentally cloned a fragment containingan open reading frame of 1849 bp from maize, which encodes a protein of 408 amino acids. BLAST analysis indicated that KAP5-4 is homologous to the qPE9-1 protein in rice. Conserved domains analysis predicted the presence of five domains. Real time reverse transcriptase polymerase chain reaction (RT-PCR) indicated that the expression of this gene is up-regulated in response to water-deficit stress in the root and leaf.Keywords: Maize, keratin-associated protein 5-4, water-deficit stress.African Journal of Biotechnology Vol. 11(29), pp. 7417-7423, 10 April, 201

Searching for Associations Between Short Gamma-ray Bursts and Fast Radio Burst

The physical origin of fast radio bursts (FRBs) is still unclear. However, young magnetars associated with short-duration gamma-ray bursts (SGRBs) have been thought to be possible central engines for some FRBs. In this paper, we perform a systematic search for SGRBs that are associated with FRBs in a sample including 623 FRBs (601 one-off bursts and 22 repeaters) and 168 SGRBs with precise localizations. We find that FRB 190309A is spatially associated with GRB 060502B, with a chance probability of 0.05 when temporal and redshift information is taken into account. Considering the high chance probability (the statistical significance is < 3{\sigma}), we examine other observational properties such as the host galaxy, the dispersion measure, and the energy budget of the central engine to check the possibility of their association. Although the available observational information is insufficient to determine whether they are physically associated, it does not rule out such a possibility. As the only pair of FRB and GRB that are spatially associated, it remains an interesting case worthy of further attentionComment: 19 pages, 4 figures, accepted to Ap

Methylation of SRD5A2 promoter predicts a better outcome for castration-resistant prostate cancer patients undergoing androgen deprivation therapy

PURPOSE: To determine whether SRD5A2 promoter methylation is associated with cancer progression during androgen deprivation therapy (ADT) in CRPC. PATIENTS AND METHODS: In a Local CRPC cohort, 42 prostatic specimens were collected from patients who were diagnosed as CRPC and underwent transurethral resection of the prostate (TURP) at Massachusetts General Hospital (MGH). In a metastatic CRPC (Met CRPC) cohort, 12 metastatic biopsies were collected from CRPC patients who would be treated with abiraterone plus dutasteride (Clinical Trial NCT01393730). As controls, 36 benign prostatic specimens were collected from patients undergoing prostate reduction surgery for symptoms of bladder outlet obstruction secondary to benign prostatic hyperplasia (BPH). The methylation status of cytosine-phosphate-guanine (CpG) site(s) at SRD5A2 promoter regions was tested. RESULTS: Compared with benign prostatic tissue, CRPC samples demonstrated higher SRD5A2 methylation in the whole promoter region (Local CRPC cohort: P \u3c 0.001; Met CRPC cohort: P \u3c 0.05). In Local CRPC cohort, a higher ratio of methylation was correlated with better OS (R2 = 0.33, P = 0.013). Hypermethylation of specific regions (nucleotides -434 to -4 [CpG# -39 to CpG# -2]) was associated with a better OS (11.3+/-5.8 vs 6.4+/-4.4 years, P = 0.001) and PFS (8.4+/-5.4 vs 4.5+/-3.9 years, P = 0.003) with cutoff value of 37.9%. Multivariate analysis showed that SRD5A2 methylation was associated with OS independently (whole promoter region: P = 0.035; specific region: P = 0.02). CONCLUSION: Our study demonstrate that SRD5A2 methylation in promoter regions, specifically at CpG# -39 to -2, is significantly associated with better survival for CRPC patients treated with ADT. Recognition of epigenetic modifications of SRD5A2 may affect the choices and sequence of available therapies for management of CRPC