Tau Neutrino Astronomy in GeV Energies

We point out the opportunity of the tau neutrino astronomy for the neutrino energy E ranging between 10 GeV and 10^3 GeV. In this energy range, the intrinsic tau neutrino production is suppressed relative to the intrinsic muon neutrino production. Any sizable tau neutrino flux may thus arise because of the \nu_{\mu}\to \nu_{\tau} neutrino oscillations only. It is demonstrated that, in the presence of the neutrino oscillations, consideration of the neutrino flavor dependence in the background atmospheric neutrino flux leads to the drastically different prospects between the observation of the astrophysical muon neutrinos and that of the astrophysical tau neutrinos. Taking the galactic-plane neutrino flux as the targeted astrophysical source, we have found that the galactic-plane tau neutrino flux dominates over the atmospheric tau neutrino flux for E > 10 GeV. Hence, the galactic-plane can at least in principle be seen through the tau neutrinos with energies just greater than 10 GeV. In a sharp contrast, the galactic-plane muon neutrino flux is overwhelmed by its atmospheric background until E > 10^6 GeV.Comment: major revision of text and two new figures, to appear in PR

α\alpha-Particle Spectrum in the Reaction p+11^{11}B→α+8Be∗→3α\to \alpha + ^8Be^*\to 3\alpha

Using a simple phenomenological parametrization of the reaction amplitude we calculated $\alpha$-particle spectrum in the reaction p+$^{11}$B$\to \alpha + ^8Be^*\to 3\alpha$ at the resonance proton energy 675 KeV. The parametrization includes Breit-Wigner factor with an energy dependent width for intermediate $^8Be^*$ state and the Coulomb and the centrifugal factors in $\alpha$-particle emission vertexes. The shape of the spectrum consists of a well defined peak corresponding to emission of the primary $\alpha$ and a flat shoulder going down to very low energy. We found that below 1.5 MeV there are 17.5% of $\alpha$'s and below 1 MeV there are 11% of them.Comment: 6 pages, 3 figure

A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity

Glutamatergic synapses display variable strength and diverse short-term plasticity (STP), even for a given type of connection. Using nonnegative tensor factorization and conventional state modeling, we demonstrate that a kinetic scheme consisting of two sequential and reversible steps of release–machinery assembly and a final step of synaptic vesicle (SV) fusion reproduces STP and its diversity among synapses. Analyzing transmission at the calyx of Held synapses reveals that differences in synaptic strength and STP are not primarily caused by variable fusion probability (pfusion) but are determined by the fraction of docked synaptic vesicles equipped with a mature release machinery. Our simulations show that traditional quantal analysis methods do not necessarily report pfusion of SVs with a mature release machinery but reflect both pfusion and the distribution between mature and immature priming states at rest. Thus, the approach holds promise for a better mechanistic dissection of the roles of presynaptic proteins in the sequence of SV docking, two-step priming, and fusion. It suggests a mechanism for activity-induced redistribution of synaptic efficacy

The Luminosity Function of Field Galaxies in the CNOC1 Redshift Survey

We have computed the luminosity function for 389 field galaxies from the Canadian Network for Observational Cosmology cluster redshift survey (CNOC1), over redshifts z = 0.2-0.6. We find Schechter parameters M^* - 5 log h = -19.6 \pm 0.3 and \alpha = -0.9 \pm 0.2 in rest-frame B_{AB}. We have also split our sample at the color of a redshifted but nonevolving Sbc galaxy, and find distinctly different luminosity functions for red and blue galaxies. Red galaxies have a shallow slope \alpha \approx -0.4 and dominate the bright end of the luminosity function, while blue galaxies have a steep \alpha \approx -1.4 and prevail at the faint end. Comparisons of the CNOC1 results to those from the Canada-France (CFRS) and Autofib redshift surveys show broad agreement among these independent samples, but there are also significant differences which will require larger samples to resolve. Also, in CNOC1 the red galaxy luminosity density stays about the same over the range z = 0.2-0.6, while the blue galaxy luminosity density increases steadily with redshift. These results are consistent with the trend of the luminosity density vs. redshift relations seen in the CFRS, though the normalizations of the luminosity densities appear to differ for blue galaxies. Comparison to the local luminosity function from the Las Campanas redshift survey (LCRS) shows that the luminosity density at z \approx 0.1 is only about half that seen at z \approx 0.4. A change in the luminosity function shape, particularly at the faint end, appears to be required to match the CNOC1 and LCRS luminosity functions, if galaxy evolution is the sole cause of the differences seen. However, it should be noted that the specific details of the construction of different surveys may complicate the comparison of results and so may need to be considered carefully.Comment: 22 pages, including 6 postscript figures, uses AASTEX v4.0 style files. Corrected minor typos and updated references. Results and conclusions unchanged. Final version to appear in the Astrophysical Journa

CD4+ T-cell responses to Epstein-Barr virus nuclear antigen EBNA1 in Chinese populations are highly focused on novel C-terminal domain-derived epitopes

Epstein-Barr virus nuclear antigen EBNA1, the one viral protein uniformly expressed in nasopharyngeal carcinoma (NPC), represents a prime target for T-cell-based immunotherapy. However, little is known about the EBNA1 epitopes, particularly CD4 epitopes, presented by HLA alleles in Chinese people, the group at highest risk for NPC. We analyzed the CD4$^+$ T-cell responses to EBNA1 in 78 healthy Chinese donors and found marked focusing on a small number of epitopes in the EBNA1 C-terminal region, including a DP5- restricted epitope that was recognized by almost half of the donors tested and elicited responses able to recognize EBNA1-expressing, DP5-positive target cells

On Behavior of a Double Rotor HAWT with a Differential Planet Gear

The mathematical model of a double disk horizontal axis wind turbine is constructed. The turbine has two propellers (actuator disks). One propeller is rigidly connected to a carrier of a planet gear, the other is rigidly connected to an external ring of the same planet gear. A rotor of an electrical generator is rigidly connected to a sun of the planet gear. The generator is included into a local electrical circuit with several consumers. The quasi-steady model of aerodynamic action is used. The electromechanical torque acting on the rotor of generator is assumed to be a linear function of an angular speed of the rotor. Existence and stability of steady motions are studied. Analysis of characteristics of steady motions such as angular speed of each propeller and mechanical power trapped from the flow is performed. A control strategy is suggested

Female Sex Development and Reproductive Duct Formation Depend on Wnt4a in Zebrafish.

In laboratory strains of zebrafish, sex determination occurs in the absence of a typical sex chromosome and it is not known what regulates the proportion of animals that develop as males or females. Many sex determination and gonad differentiation genes that act downstream of a sex chromosome are well conserved among vertebrates, but studies that test their contribution to this process have mostly been limited to mammalian models. In mammals, WNT4 is a signaling ligand that is essential for ovary and Müllerian duct development, where it antagonizes the male-promoting FGF9 signal. Wnt4 is well conserved across all vertebrates, but it is not known if Wnt4 plays a role in sex determination and/or the differentiation of sex organs in nonmammalian vertebrates. This question is especially interesting in teleosts, such as zebrafish, because they lack an Fgf9 ortholog. Here we show that wnt4a is the ortholog of mammalian Wnt4, and that wnt4b was present in the last common ancestor of humans and zebrafish, but was lost in mammals. We show that wnt4a loss-of-function mutants develop predominantly as males and conclude that wnt4a activity promotes female sex determination and/or differentiation in zebrafish. Additionally, both male and female wnt4a mutants are sterile due to defects in reproductive duct development. Together these results strongly argue that Wnt4a is a conserved regulator of female sex determination and reproductive duct development in mammalian and nonmammalian vertebrates