Pediatric asthma and autism-genomic perspectives.

High-throughput technologies, ranging from microarrays to NexGen sequencing of RNA and genomic DNA, have opened new avenues for exploration of the pathobiology of human disease. Comparisons of the architecture of the genome, identification of mutated or modified sequences, and pre-and post- transcriptional regulation of gene expression as disease specific biomarkers are revolutionizing our understanding of the causes of disease and are guiding the development of new therapies. There is enormous heterogeneity in types of genomic variation that occur in human disease. Some are inherited, while others are the result of new somatic or germline mutations or errors in chromosomal replication. In this review, we provide examples of changes that occur in the human genome in two of the most common chronic pediatric disorders, autism and asthma. The incidence and economic burden of both of these disorders are increasing worldwide. Genomic variations have the potential to serve as biomarkers for personalization of therapy and prediction of outcomes

Towards Optimal Discrete Online Hashing with Balanced Similarity

When facing large-scale image datasets, online hashing serves as a promising solution for online retrieval and prediction tasks. It encodes the online streaming data into compact binary codes, and simultaneously updates the hash functions to renew codes of the existing dataset. To this end, the existing methods update hash functions solely based on the new data batch, without investigating the correlation between such new data and the existing dataset. In addition, existing works update the hash functions using a relaxation process in its corresponding approximated continuous space. And it remains as an open problem to directly apply discrete optimizations in online hashing. In this paper, we propose a novel supervised online hashing method, termed Balanced Similarity for Online Discrete Hashing (BSODH), to solve the above problems in a unified framework. BSODH employs a well-designed hashing algorithm to preserve the similarity between the streaming data and the existing dataset via an asymmetric graph regularization. We further identify the "data-imbalance" problem brought by the constructed asymmetric graph, which restricts the application of discrete optimization in our problem. Therefore, a novel balanced similarity is further proposed, which uses two equilibrium factors to balance the similar and dissimilar weights and eventually enables the usage of discrete optimizations. Extensive experiments conducted on three widely-used benchmarks demonstrate the advantages of the proposed method over the state-of-the-art methods.Comment: 8 pages, 11 figures, conferenc

Periodic Radio Variability in NRAO 530: Phase Dispersion Minimization Analysis

In this paper, a periodicity analysis of the radio light curves of the blazar NRAO 530 at 14.5, 8.0, and 4.8 GHz is presented employing an improved Phase Dispersion Minimization (PDM) technique. The result, which shows two persistent periodic components of $\sim 6$ and $\sim 10$ years at all three frequencies, is consistent with the results obtained with the Lomb-Scargle periodogram and weighted wavelet Z-transform algorithms. The reliability of the derived periodicities is confirmed by the Monte Carlo numerical simulations which show a high statistical confidence. (Quasi-)Periodic fluctuations of the radio luminosity of NRAO 530 might be associated with the oscillations of the accretion disk triggered by hydrodynamic instabilities of the accreted flow. \keywords{methods: statistical -- galaxies: active -- galaxies: quasar: individual: NRAO 530}Comment: 8 pages, 5 figures, accepted by RA

COMPARISON OF PLANTAR LOAD WHEN RUNNING ON TREADMILL AND ON CEMENT AND GRASS OVERGROUND SURFACES

The objective of this study was to compare plantar loads during running on a treadmill and on concrete and grass surfaces. Sixteen experienced heel-to-toe runners participated in the study. Plantar loads were collected using a Novel Pedar insole sensor system during running at 3.8 m/s. Compared with running on the two other surfaces, treadmill running showed a lower magnitude of maximum plantar pressure and maximum plantar force for the total foot, maximum plantar pressure for the two toe regions, maximum plantar force for the medial forefoot and the two toe regions, and longer absolute contact time at the two toe regions (

Efficacy of Ultrasound-guided Radiofrequency Ablation of Parathyroid Hyperplasia: Single Session vs. Two-Session for Effect on Hypocalcemia

To evaluate safety and efficacy of one- vs. two-session radiofrequency ablation (RFA) of parathyroid hyperplasia for patients with secondary hyperparathyroidism (SHPT) and to compare the outcome of both methods on hypocalcemia. Patients with secondary hyperparathyroidism underwent ultrasound guided RFA of parathyroid hyperplasia. Patients were alternately assigned to either group 1 (n = 28) with RFA of all 4 glands in one session or group 2 (n = 28) with RFA of 2 glands in a first session and other 2 glands in a second session. Serum parathyroid hormone (PTH), calcium, phosphorus and alkaline phosphatase (ALP) values were measured at a series of time points after RFA. RFA parameters, including operation duration and ablation time and hospitalization length and cost, were compared between the two groups. Mean PTH decreased in group 1 from 1865.18 ± 828.93 pg/ml to 145.72 ± 119.27 pg/ml at 1 day after RFA and in group 2 from 2256.64 ± 1021.72 pg/ml to 1388.13 ± 890.15 pg/ml at 1 day after first RFA and to 137.26 ± 107.12 pg/ml at 1 day after second RFA. Group 1\u27s calcium level decreased to 1.79 ± 0.31 mmol/L at day 1 after RFA and group 2 decreased to 1.89 ± 0.26 mmol/L at day 1 after second session RFA (P \u3c 0.05). Multivariate analysis showed that hypocalcemia was related to serum ALP. Patients with ALP ≥ 566 U/L had lower calcium compared to patients with ALP \u3c 566 U/L up to a month after RFA (P \u3c 0.05). Group 1\u27s RFA time and hospitalization were shorter and had lower cost compared with Group 2. US-guided RFA of parathyroid hyperplasia is a safe and effective method for treating secondary hyperparathyroidism. Single-session RFA was more cost-effective and resulted in a shorter hospital stay compared to two sessions. However, patients with two-session RFA had less hypocalcemia, especially those with high ALP