Predictors of treatment failure after multiple imputation: odds ratios and confidence intervals.

<p>CI: confidence interval; MUAC: mid-upper arm circumference; PCV13: 13 valent pneumococcal conjugate vaccine. ‘Fast’ respiratory rate was defined as >50 breaths per minute for infants aged 2–11 months and >40 breath per minute for 12-59months, and ‘very fast’ was >70 breaths per minute for infants aged 2–11 months and >60 breath per minute for 12-59months.</p><p>*p-value<0.05</p><p>Predictors of treatment failure after multiple imputation: odds ratios and confidence intervals.</p

Risk predictiveness curve.

<p>The solid line indicates children’s predicted risk of treatment failure. For each quintile of predicted risk, we plotted the observed risks of treatment failure (open circles). The agreement between the predicted and observed risks measures the calibration.</p

Observed and predicted treatment failure.

<p>The dotted line plots the observed vs. predicted probability of treatment failure the solid line is a bias-corrected version (40 bootstrap repetitions). The rug plot along the top of the graph indicates the distribution of the predicted probabilities.</p

Participant flow diagram for inclusion in the prognostic algorithm model.

<p>Participant flow diagram for inclusion in the prognostic algorithm model.</p

Clinical and hypoxemic pneumonia definitions

<p>Clinical and hypoxemic pneumonia definitions</p

Changes in case burden of clinical and hypoxemic pneumonia in children (0–59 months)

<p>Changes in case burden of clinical and hypoxemic pneumonia in children (0–59 months)</p

Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Clinical and Hypoxemic Childhood Pneumonia over Three Years in Central Malawi: An Observational Study - Fig 2

<p><b>Pneumonia cases and deaths in children under 5 years old by month: January 2012–June 2014:</b> a) Total clinical pneumonia cases at all hospitals, health centres and community health worker clinics b) Clinical pneumonia cases at all hospitals, health centres and community health worker clinics by category c) Hypoxemic pneumonia cases at all hospitals, health centres and community health worker clinics d) Hospital pneumonia deaths.</p

Map of study sites

<p>Map of study sites</p

Clinical pneumonia, hypoxemic pneumonia, outcome, and PCV13 status by health system level in Lilongwe and Mchinji districts, Malawi

<p>Clinical pneumonia, hypoxemic pneumonia, outcome, and PCV13 status by health system level in Lilongwe and Mchinji districts, Malawi</p