Effect of Topical Application of Different Substances on Fibroplasia in Cutaneous Surgical Wounds

Background. Fibroblasts on the edges of a surgical wound are induced to synthesize collagen during the healing process which is known as fibroplasia. Objective. The aim of this study was to determine the effect of the application of different substances on fibroplasia of cutaneous surgical wounds on rats. Materials and Methods. 48 Wistar rats were divided into three groups. A surgical wound 1 cm in diameter and 1  mm in depth was created on the dorsum of each animal. The surgical wounds were submitted to the topical application of an alcoholic extract of 30% propolis, 70% alcohol, or 0.001% dexamethasone in a cream base every 12 hours. The animals were sacrificed three, seven, 14, and 28 days postoperatively. The specimens were histologically processed and stained with Masson's trichrome. The assessment of fibroplasia was performed using a scoring system: (1) 5 to 25% collagen deposition; (2) 26 to 50% collagen deposition; (3) 51 to 75% collagen deposition; (4) more than 75% collagen deposition. Results. There were statistically significant differences in collagen deposition between the substances at all postoperative evaluation times. Conclusion. Propolis and alcohol promoted greater collagen deposition in surgical wounds than dexamethasone

The study of morphologic changes induced by urethane in an oral chemical carcinogenesis DMBA-induced model

A proposta deste trabalho resultou da necessidade de se avaliar o potencial carcinogênico da uretana, em concentragoes mais baixas, a partir do modelo experimental de carcinogenese bucal DMBA-induzida. Cem hamsters sírios dourados foram separados em cinco grupos experimentais. 0 grupo 1 recebeu aplicações topicas de uretana 0.5% na borda lateral da língua; grupo 2, uretana 6%; grupo 3 uretana 0.5% + DMBA; grupo 4, uretana 6% + DMBA, e o grupo 5 — DMBA (controle positivo). Os dados obtidos mostraram que a uretana a 0.5% e 6% não induziu alterações histolOgicas nos grupos 1 e 2. A formação de carcinomas nos animais tratados com uretana e DMBA ocorreu em proporções menores quando comparada com o grupo controle positivo (DMBA). A uretana a 0.5% e 6% reduziu a carcinogenicidade do DMBA, e não apresentou potencial carcinogenic° de iniciação, promoção e/ou progressão.The study examined the carcinogenic potential of urethane in lower concent:ration forms according to the experimental oral carcinogenese DMBA-induced model. One hundred Syrian golden hamsters were separated in five experimental groups. Group 1 receivecl 0.5% urethane topical applications along in the lateral border of the tongue; group 2, 6% urethane; group 3, 0.5% urethane + 9,10 dimethyl 1,2-benzantracene (DMBA); group 4, 6% urethane + DMBA; and group 5, assigned positive control, DMBA. The results indicated no histological alterations in groups 1 anel 2 inducecl by 0.5% and 6% urethane. The formation of carcinomas in animals treated with urethane and DMBA wa:s visible in lesser proportions when compareci with the positive control group (DMBA). The 0.5% and 6% urethane decreased carcinogenicity of DMBA and did not present carcinogenic potential for initiation, promotion and/or its progression

Basosquamous carcinoma: Histopathological features

Basosquamous carcinoma (BSC) is a rare aggressive epithelial neoplasm with features of both basal cell carcinoma and squamous cell carcinoma, with a tendency toward local recurrence and a propensity for lymph node and distant metastases. The aim of the present study was to report the case of a 63-year-old Caucasian male with BSC in the auricular region