The Evolutionarily Conserved LIM Homeodomain Protein LIM-4/LHX6 Specifies the Terminal Identity of a Cholinergic and Peptidergic C. elegans Sensory/Inter/Motor Neuron-Type

The expression of specific transcription factors determines the differentiated features of postmitotic neurons. However, the mechanism by which specific molecules determine neuronal cell fate and the extent to which the functions of transcription factors are conserved in evolution are not fully understood. In C. elegans, the cholinergic and peptidergic SMB sensory/inter/motor neurons innervate muscle quadrants in the head and control the amplitude of sinusoidal movement. Here we show that the LIM homeobox protein LIM-4 determines neuronal characteristics of the SMB neurons. In lim-4 mutant animals, expression of terminal differentiation genes, such as the cholinergic gene battery and the flp-12 neuropeptide gene, is completely abolished and thus the function of the SMB neurons is compromised. LIM-4 activity promotes SMB identity by directly regulating the expression of the SMB marker genes via a distinct cis-regulatory motif. Two human LIM-4 orthologs, LHX6 and LHX8, functionally substitute for LIM-4 in C. elegans. Furthermore, C. elegans LIM-4 or human LHX6 can induce cholinergic and peptidergic characteristics in the human neuronal cell lines. Our results indicate that the evolutionarily conserved LIM-4/LHX6 homeodomain proteins function in generation of precise neuronal subtypes

How To Kill a Penguin

Within constrained minimal-flavor-violation the large destructive flavor-changing Z-penguin managed to survive eradication so far. We give a incisive description of how to kill it using the precision measurements of the Z -> b anti-b pseudo observables. The derived stringent range for the non-standard contribution to the universal Inami-Lim function C leads to tight two-sided limits for the branching ratios of all Z-penguin dominated flavor-changing K- and B-decays.Comment: 5 pages, 4 figures, 1 table, uses pdflatex, talk given at DIS 2007, Muenchen, Germany, April 15--20, 200

Representasi Perilaku Bullying Serial Drama Korea True Beauty

The drama entitled True Beauty is a Korean drama produced by tvN which was released in 2020 directed by Kim Sang Hyub. In this study, researchers used Charles Sanders Peirce's theory of semiotic analysis. Charles Sanders Peirce's theory emphasizes that criminal behavior is not due to heredity, but social/social environmental factors. The purpose of this research is to represent bullying, which the researchers found that there are three types of bullying that occur in this drama, namely physical bullying, verbal bullying, and psychological bullying. The method used is to group signs based on scenes related to the representation of bullying in the drama, which is then explained in each type of bullying scene. The conclusion of the study was that students bullied Lim Ju Kyung and Han Go Won on the grounds that both Lim Ju Kyung and Han Go Won had ugly looks. So that students at the school carry out bullying in the form of slapping, grabbing, pushing, insulting, threatening, giving nicknames, and looking down on victims. These actions can cause the victim to become insecure, easily scared, and can even lead to suicide