Three-dimensional calculation of shuttle charging in polar orbit

The charged particles environment in polar orbit can be of sufficient intensity to cause spacecraft charging. In order to gain a quantitative understanding of such effects, the Air Force is developing POLAR, a computer code which simulates in three dimensions the electrical interaction of large space vehicles with the polar ionospheric plasma. It models the physical processes of wake generation, ambient ion collection, precipitating auroral electron fluxes, and surface interactions, including secondary electron generation and backscattering, which lead to vehicle charging. These processes may be followed dynamically on a subsecond timescale so that the rapid passage through intense auroral arcs can be simulated. POLAR models the ambient plasma as isotropic Maxwellian electrons and ions (0+, H+), and allows for simultaneous precipitation of power-law, energetic Maxwellian, and accelerated Gaussian distributions of electrons. Magnetic field effects will be modeled in POLAR but are currently ignored

Wrapping Transition and Wrapping-Mediated Interactions for Discrete Binding along an Elastic Filament: An Exact Solution

The wrapping equilibria of one and two adsorbing cylinders are studied along a semi-flexible filament (polymer) due to the interplay between elastic rigidity and short-range adhesive energy between the cylinder and the filament. We show that statistical mechanics of the system can be solved exactly using a path integral formalism which gives access to the full effect of thermal fluctuations, going thus beyond the usual Gaussian approximations which take into account only the contributions from the minimal energy configuration and small fluctuations about this minimal energy solution. We obtain the free energy of the wrapping-unwrapping transition of the filament around the cylinders as well as the effective interaction between two wrapped cylinders due to thermal fluctuations of the elastic filament. A change of entropy due to wrapping of the filament around the adsorbing cylinders as they move closer together is identified as an additional source of interactions between them. Such entropic wrapping effects should be distinguished from the usual entropic configuration effects in semi-flexible polymers. Our results may be applicable to the problem of adsorption of proteins as well as synthetic nano-particles on semi-flexible polymers such as DNA.Comment: 24 pages, 12 figure

DNA cruciform arms nucleate through a correlated but non-synchronous cooperative mechanism

Inverted repeat (IR) sequences in DNA can form non-canonical cruciform structures to relieve torsional stress. We use Monte Carlo simulations of a recently developed coarse-grained model of DNA to demonstrate that the nucleation of a cruciform can proceed through a cooperative mechanism. Firstly, a twist-induced denaturation bubble must diffuse so that its midpoint is near the centre of symmetry of the IR sequence. Secondly, bubble fluctuations must be large enough to allow one of the arms to form a small number of hairpin bonds. Once the first arm is partially formed, the second arm can rapidly grow to a similar size. Because bubbles can twist back on themselves, they need considerably fewer bases to resolve torsional stress than the final cruciform state does. The initially stabilised cruciform therefore continues to grow, which typically proceeds synchronously, reminiscent of the S-type mechanism of cruciform formation. By using umbrella sampling techniques we calculate, for different temperatures and superhelical densities, the free energy as a function of the number of bonds in each cruciform along the correlated but non-synchronous nucleation pathways we observed in direct simulations.Comment: 12 pages main paper + 11 pages supplementary dat

Quark Masses: An Environmental Impact Statement

We investigate worlds that lie on a slice through the parameter space of the Standard Model over which quark masses vary. We allow as many as three quarks to participate in nuclei, while fixing the mass of the electron and the average mass of the lightest baryon flavor multiplet. We classify as "congenial" worlds that satisfy the environmental constraint that the quark masses allow for stable nuclei with charges one, six, and eight, making organic chemistry possible. Whether a congenial world actually produces observers depends on a multitude of historical contingencies, beginning with primordial nucleosynthesis, which we do not explore. Such constraints may be independently superimposed on our results. Environmental constraints such as the ones we study may be combined with information about the a priori distribution of quark masses over the landscape of possible universes to determine whether the measured values of the quark masses are determined environmentally, but our analysis is independent of such an anthropic approach. We estimate baryon masses as functions of quark masses and nuclear masses as functions of baryon masses. We check for the stability of nuclei against fission, strong particle emission, and weak nucleon emission. For two light quarks with charges 2/3 and -1/3, we find a band of congeniality roughly 29 MeV wide in their mass difference. We also find another, less robust region of congeniality with one light, charge -1/3 quark, and two heavier, approximately degenerate charge -1/3 and 2/3 quarks. No other assignment of light quark charges yields congenial worlds with two baryons participating in nuclei. We identify and discuss the region in quark-mass space where nuclei would be made from three or more baryon species.Comment: 40 pages, 16 figures (in color), 4 tables. See paper for a more detailed abstract. v4: Cleaning up minor typo

On separating propagating and non-propagating dynamics in fluid-flow equations

The ability to separate acoustically radiating and non-radiating components in fluid flow is desirable to identify the true sources of aerodynamic sound, which can be expressed in terms of the non-radiating flow dynamics. These non-radiating components are obtained by filtering the flow field. Two linear filtering strategies are investigated: one is based on a differential operator, the other employs convolution operations. Convolution filters are found to be superior at separating radiating and non-radiating components. Their ability to decompose the flow into non-radiating and radiating components is demonstrated on two different flows: one satisfying the linearized Euler and the other the Navier-Stokes equations. In the latter case, the corresponding sound sources are computed. These sources provide good insight into the sound generation process. For source localization, they are found to be superior to the commonly used sound sources computed using the steady part of the flow

Human ANKLE1 is a nuclease specific for branched DNA

All physical connections between sister chromatids must be broken before cells can divide, and eukaryotic cells have evolved multiple ways in which to process branchpoints connecting DNA molecules separated both spatially and temporally. A single DNA link between chromatids has the potential to disrupt cell cycle progression and genome integrity, so it is highly likely that cells require a nuclease that can process remaining unresolved and hemi-resolved DNA junctions and other branched species at the very late stages of mitosis. We argue that ANKLE1 probably serves this function in human cells (LEM-3 in Caenorhabditis elegans). LEM-3 has previously been shown to be located at the cell mid-body, and we show here that human ANKLE1 is a nuclease that cleaves a range of branched DNA species. It thus has the substrate selectivity consistent with an enzyme required to process a variety of unresolved and hemi-resolved branchpoints in DNA. Our results suggest that ANKLE1 acts as a catch-all enzyme of last resort that allows faithful chromosome segregation and cell division to occur. (C) 2020 The Author(s). Published by Elsevier Ltd

Making the user more efficient: Design for sustainable behaviour

User behaviour is a significant determinant of a product’s environmental impact; while engineering advances permit increased efficiency of product operation, the user’s decisions and habits ultimately have a major effect on the energy or other resources used by the product. There is thus a need to change users’ behaviour. A range of design techniques developed in diverse contexts suggest opportunities for engineers, designers and other stakeholders working in the field of sustainable innovation to affect users’ behaviour at the point of interaction with the product or system, in effect ‘making the user more efficient’. Approaches to changing users’ behaviour from a number of fields are reviewed and discussed, including: strategic design of affordances and behaviour-shaping constraints to control or affect energyor other resource-using interactions; the use of different kinds of feedback and persuasive technology techniques to encourage or guide users to reduce their environmental impact; and context-based systems which use feedback to adjust their behaviour to run at optimum efficiency and reduce the opportunity for user-affected inefficiency. Example implementations in the sustainable engineering and ecodesign field are suggested and discussed

A complex ray-tracing tool for high-frequency mean-field flow interaction effects in jets

This paper presents a complex ray-tracing tool for the calculation of high-frequency Green’s functions in 3D mean field jet flows. For a generic problem, the ray solution suffers from three main deficiencies: multiplicity of solutions, singularities at caustics, and the determining of complex solutions. The purpose of this paper is to generalize, combine and apply existing stationary media methods to moving media scenarios. Multiplicities are dealt with using an equivalent two-point boundary-value problem, whilst non-uniformities at caustics are corrected using diffraction catastrophes. Complex rays are found using a combination of imaginary perturbations, an assumption of caustic stability, and analytic continuation of the receiver curve. To demonstrate this method, the ray tool is compared against a high-frequency modal solution of Lilley’s equation for an off-axis point source. This solution is representative of high-frequency source positions in real jets and is rich in caustic structures. A full utilization of the ray tool is shown to provide excellent results<br/