The magnetotelluric tensor: improved invariants for its decomposition, especially 'the 7th'

A decomposition of the magnetotelluric tensor is described in terms of quantities which are invariant to the rotation of observing axes, and which also are distinct measures of the 1D, 2D or 3D characteristics of the tensor and so may be useful in dimensionality analysis. When the in-phase and quadrature parts of the tensor are analysed separately there are two invariants which gauge 1D structure, two invariants which gauge 2D structure, and three invariants which gauge 3D structure. A matrix method similar to singular value decomposition is used to determine many of the invariants, and their display is then possible on Mohr diagrams. A particular set of invariants proposed some seventeen years ago is revised to yield an improved set. Several possibilities for the seventh invariant are canvassed, and illustrated by examples from field data. Low values of Δβ, the invariant now preferred for 'the 7th', may indicate a particular simplification of otherwise complicated three-dimensional structure

The sign convention for quadrature Parkinson arrows in geomagnetic induction studies

Time series analysis, which is basic to modern geophysical data processing, involves a choice between working with a time dependence of e+iωt or e-iωt. In published work the choice made is sometimes not explicitly stated, leaving ambiguity in the interpretation of complex quantities with quadrature parts. Parkinson arrows are used in geomagnetic induction studies to summarize anomalous vertical magnetic fluctuations at different observing stations and to indicate regions of high electrical conductivity. Such arrows are now regularly computed as real and quadrature pairs. The general convention is often adopted of 'reversing' a calculated real arrow so that it will point toward a conductivity increase, but for quadrature arrows the practice between various published papers has generally not been so consistent. The present paper demonstrates that consistent practice for reversing or not reversing quadrature Parkinson arrows is possible when the initial convention for time dependence is taken into account. A reversal practice is determined for interpretation in terms of a simple channeling model. A related matter is the definition of phase. Phase values are also generally ambiguous unless the time dependence used (e-iωt or e+iωt) is stated

Rethinking animal models of sepsis - working towards improved clinical translation whilst integrating the 3Rs.

Sepsis is a major worldwide healthcare issue with unmet clinical need. Despite extensive animal research in this area, successful clinical translation has been largely unsuccessful. We propose one reason for this is that, sometimes, the experimental question is misdirected or unrealistic expectations are being made of the animal model. As sepsis models can lead to a rapid and substantial suffering - it is essential that we continually review experimental approaches and undertake a full harm:benefit impact assessment for each study. In some instances, this may require refinement of existing sepsis models. In other cases, it may be replacement to a different experimental system altogether, answering a mechanistic question whilst aligning with the principles of reduction, refinement and replacement (3Rs). We discuss making better use of patient data to identify potentially useful therapeutic targets which can subsequently be validated in preclinical systems. This may be achieved through greater use of construct validity models, from which mechanistic conclusions are drawn. We argue that such models could provide equally useful scientific data as face validity models, but with an improved 3Rs impact. Indeed, construct validity models may not require sepsis to be modelled, per se. We propose that approaches that could support and refine clinical translation of research findings, whilst reducing the overall welfare burden on research animals

DNA cruciform arms nucleate through a correlated but non-synchronous cooperative mechanism

Inverted repeat (IR) sequences in DNA can form non-canonical cruciform structures to relieve torsional stress. We use Monte Carlo simulations of a recently developed coarse-grained model of DNA to demonstrate that the nucleation of a cruciform can proceed through a cooperative mechanism. Firstly, a twist-induced denaturation bubble must diffuse so that its midpoint is near the centre of symmetry of the IR sequence. Secondly, bubble fluctuations must be large enough to allow one of the arms to form a small number of hairpin bonds. Once the first arm is partially formed, the second arm can rapidly grow to a similar size. Because bubbles can twist back on themselves, they need considerably fewer bases to resolve torsional stress than the final cruciform state does. The initially stabilised cruciform therefore continues to grow, which typically proceeds synchronously, reminiscent of the S-type mechanism of cruciform formation. By using umbrella sampling techniques we calculate, for different temperatures and superhelical densities, the free energy as a function of the number of bonds in each cruciform along the correlated but non-synchronous nucleation pathways we observed in direct simulations.Comment: 12 pages main paper + 11 pages supplementary dat

Quark Masses: An Environmental Impact Statement

We investigate worlds that lie on a slice through the parameter space of the Standard Model over which quark masses vary. We allow as many as three quarks to participate in nuclei, while fixing the mass of the electron and the average mass of the lightest baryon flavor multiplet. We classify as "congenial" worlds that satisfy the environmental constraint that the quark masses allow for stable nuclei with charges one, six, and eight, making organic chemistry possible. Whether a congenial world actually produces observers depends on a multitude of historical contingencies, beginning with primordial nucleosynthesis, which we do not explore. Such constraints may be independently superimposed on our results. Environmental constraints such as the ones we study may be combined with information about the a priori distribution of quark masses over the landscape of possible universes to determine whether the measured values of the quark masses are determined environmentally, but our analysis is independent of such an anthropic approach. We estimate baryon masses as functions of quark masses and nuclear masses as functions of baryon masses. We check for the stability of nuclei against fission, strong particle emission, and weak nucleon emission. For two light quarks with charges 2/3 and -1/3, we find a band of congeniality roughly 29 MeV wide in their mass difference. We also find another, less robust region of congeniality with one light, charge -1/3 quark, and two heavier, approximately degenerate charge -1/3 and 2/3 quarks. No other assignment of light quark charges yields congenial worlds with two baryons participating in nuclei. We identify and discuss the region in quark-mass space where nuclei would be made from three or more baryon species.Comment: 40 pages, 16 figures (in color), 4 tables. See paper for a more detailed abstract. v4: Cleaning up minor typo

Geomagnetic induction and conductive structures in north-west India

Magnetic disturbance events and quiet daily variation as recorded by the 1979 magnetometer array study in north-west India are analysed for evidence of electrical conductivity structures in the region. Contour maps of Fourier transform parameters are presented, and the disturbance event data are also reduced to sets of real and quadrature Parkinson arrows over a range of periods. A variety of conductive structures in the area are mapped, including some relatively shallow ones thought to be caused by sediments, as in the Ganga basin. More information is obtained on a major conductivity structure which strikes perpendicular to the Ganga basin into the foothills of the Himalayas; a second major conductivity structure is detected to lie to the west of the array area, and may be associated there with some aspect of the suture zone of India and Asia

Assessing risks and mitigating impacts of harmful algal blooms on mariculture and marine fisheries

Aquaculture is the fastest growing food sector globally and protein provisioning from aquaculture now exceeds that from wild capture fisheries. There is clear potential for the further expansion of marine aquaculture (mariculture), but there are associated risks. Some naturally occurring algae can proliferate under certain environmental conditions, causing deoxygenation of seawater, or releasing toxic compounds (phycotoxins), which can harm wild and cultured finfish and shellfish, and also human consumers. The impacts of these so‐called harmful algal blooms (HABs) amount to approximately 8 $billion/yr globally, due to mass mortalities in finfish, harvesting bans preventing the sale of shellfish that have accumulated unsafe levels of HAB phycotoxins and unavoided human health costs. Here, we provide a critical review and analysis of HAB impacts on mariculture (and wild capture fisheries) and recommend research to identify ways to minimise their impacts to the industry. We examine causal factors for HAB development in inshore versus offshore locations and consider how mariculture itself, in its various forms, may exacerbate or mitigate HAB risk. From a management perspective, there is considerable scope for strategic siting of offshore mariculture and holistic Environmental Approaches for Aquaculture, such as offsetting nutrient outputs from finfish farming, via the co‐location of extractive shellfish and macroalgae. Such pre‐emptive, ecosystem‐based approaches are preferable to reactive physical, chemical or microbiological control measures aiming to remove or neutralise HABs and their phycotxins. To facilitate mariculture expansion and long‐term sustainability, it is also essential to evaluate HAB risk in conjunction with climate change

A complex ray-tracing tool for high-frequency mean-field flow interaction effects in jets

This paper presents a complex ray-tracing tool for the calculation of high-frequency Green’s functions in 3D mean field jet flows. For a generic problem, the ray solution suffers from three main deficiencies: multiplicity of solutions, singularities at caustics, and the determining of complex solutions. The purpose of this paper is to generalize, combine and apply existing stationary media methods to moving media scenarios. Multiplicities are dealt with using an equivalent two-point boundary-value problem, whilst non-uniformities at caustics are corrected using diffraction catastrophes. Complex rays are found using a combination of imaginary perturbations, an assumption of caustic stability, and analytic continuation of the receiver curve. To demonstrate this method, the ray tool is compared against a high-frequency modal solution of Lilley’s equation for an off-axis point source. This solution is representative of high-frequency source positions in real jets and is rich in caustic structures. A full utilization of the ray tool is shown to provide excellent results<br/