Integral Finite Surgeries on Knots in S³

Using the correction terms in Heegaard Floer homology, we prove that if a knot in S3 admits a positive integral T-, O-, or I-type surgery, it must have the same knot Floer homology as one of the knots given in our complete list, and the resulting manifold is orientation-preservingly homeomorphic to the p-surgery on the corresponding knot

Investigations of Bio-responsive Peptide-inorganic Nanomaterials

Growth in nanotechnology has been fuelled by miniaturization of electronic systems, development of biomedical sciences and interest in nanomaterials that exhibit interesting properties. Current techniques to fabricate small devices have difficulty in accessing the size range between 10-100 nm, and conjugation of biomolecules with inorganic nanoparticles (NPs) can potentially be used to bridge this gap. Biological functions of living cells operate in the nanoscale and there is great potential in using bionanotechnology to discover new biomedical applications in diagnostics, drug delivery and cancer therapy. In this thesis, N-fluorenylmethoxycarbonyl (Fmoc)-protected peptides are explored as tethers to self-assemble gold NPs. Assembly is characterized by transmission electron microscopy, UV-visible spectroscopy, Raman spectroscopy, zeta potential measurements, dynamic light scattering and a new technique, Nanoparticle Tracking Analysis system (NTA). Solutions of gold NPs exhibit unique colour changes depending on their aggregation state, and the use of peptide-functionalised NPs (peptide-NPs) in a novel approach of protease sensing is developed here. Detection of the protease, Thermolysin from Bacillus thermoproteolyticus Rokko was demonstrated, and design of peptide-NPs was further optimized for detection of two medically relevant proteases, non-bindingto- alpha-chymotrypsin prostate specific antigen (nACT-PSA) and human neutrophil elastase (HNE). nACT-PSA and HNE are proteases related to prostate cancer and lung diseases respectively, and detection of PSA using the engineered peptide-NPs resulted in higher sensitivity than previously reported approaches. Surface enhanced Raman scattering was also used to monitor thermolysin action on peptide-NPs, in a novel approach which gave higher sensitivity than when using UVvisible spectroscopy for detection. The quartz crystal microbalance was also applied in complementary measurements to elucidate enzyme action on the peptides. The successful approach demonstrated here of using peptides to self-assemble gold NPs could pave new ways for the fabrication of small devices. Novel approaches of protease-sensing using peptide-NPs further illustrate potential of nanomaterials for new biomedical applications

ANALISIS IMPLEMENTASI PEMBELAJARAN SCIENTIFIC APPROACH DENGAN MODEL DISCOVERY LEARNING DAN CONTEXTUAL TEACHING PADA KURIKULUM 2013

Penelitian ini bertujuan untuk menganalisis perencanaan dan pelaksanaan pembelajaran dalam implementasi pembelajaran scientific approach dengan model discovery learning dan contextual teaching and learning di SMK Negeri I Mundu Cirebon.Penelitian dilakukan menggunakan metode deskriptif. Subjek penelitian ini adalah peserta didik kelas X dan XI TPHPi dan guru TPHPi sebagai responden. Objek dalam penelitian ini adalah kegiatan pembelajaran yang merupakan bentuk dari implementasi discovery learning dan contextual teaching and learning. Instrumen dalam penelitian ini berupa pedoman analisis RPP dan pedoman analisis observasi keterlaksanaan discovery learning dan contextual teaching and learning. Data dianalisis menggunakan uji persentase dan pengukurannya menggunakan skala Guttman.Hasil penelitian menunjukan bahwa (1) hasil analisis pada dokumen RPP responden I dengan menggunakan model Discovery Learningsebesar 93,75% dengan kategori “Sangat Baik”. (2) hasil analisis pada dokumen RPP responden II dengan menggunakan model Contextual Teaching and Learning sebesar 93,75% dengan kategori “Sangat Baik”. (3) hasil analisis pada observasi keterlaksanaan dalam kegiatan belajar mengajar responden I dengan menggunakan model Discovery Learningsebesar 87,87% dengan kategori “Sangat Baik”. (4) hasil analisis pada observasi keterlaksanaan dalam kegiatan belajar mengajar responden II dengan menggunakan model Contextual Teaching and Learning sebesar 81,81% dengan kategori “Sangat Baik”. Dapat disimpulkan bahwa pembelajaran scientific approach dengan model discovery learning dan contextual teaching and learning di kelas X dan XI TPHPi SMK Negeri I Mundu terimplementasi dengan sangat baik.---------- The purpose of this study to analyze the implementation of lesson plan and teaching learning activity in scientific approach using discovery learning model and contextual teaching learning in SMK Negeri I MunduCirebon. This study is using descriptive method. Subject of this study is students from class X and XI TPHPi and teacher TPHPi as a respondents. Object in this study is learning activities which used implementation of discovery learning and contextual teaching and learning. The form of instrument in this study used as a guidelines in analyzing RPP and observing the implementation discovery learning and contextual teaching and learning. Data was analyzed using test presentage and measured by using Guttman scale. The result showed;(1) the analysis on a document lesson plans respondents I with use the model discovery learning of 93,75% to the category of “very good”; (2) the analysis on a document lesson plans respondents II and use the contextual teaching and learning model of 93,75% with category “very good”; (3) The results of the analysis in spectroscopis observations in learning activities respondents I and use discovery learning model of 87,87% with category “very good”(4) The results of the analysis in spectroscopis observations in learning activities respondents II and use contextual teaching and learning model of 81,81% with category “very good”. The conclusion of this study, implementation scientific approach learning using discovery learning models and contextual teaching and learning in class X and XI TPHPi SMK Negeri I Mundu Cirebon was very good

Efficient CO2 Sorbents Based on Silica Foam with Ultra-large Mesopores

A series of high-capacity, amine impregnated sorbents based on a cost-effective silica foam with ultra-large mesopores is reported. The sorbents exhibit fast CO2 capture kinetics, high adsorption capacity (of up to 5.8 mmol g−1 under 1 atm of dry CO2), as well as good stability over multiple adsorption–desorption cycles. A simple theoretical analysis is provided relating the support structure to sorbent performance.This publication was based on work supported by Award no. KUS-C1-018-02, made by King Abdullah University of Science and Technology (KAUST)

Quantum phases of SrCu2(BO3)2 from high-pressure thermodynamics

We report heat capacity measurements of SrCu$_2$(BO$_3$)$_2$ under high pressure along with simulations of relevant quantum spin models and map out the $(P,T)$ phase diagram of the material. We find a first-order quantum phase transition between the low-pressure quantum dimer paramagnet and a phase with signatures of a plaquette-singlet state below T = $2$ K. At higher pressures, we observe a transition into a previously unknown antiferromagnetic state below $4$ K. Our findings can be explained within the two-dimensional Shastry-Sutherland quantum spin model supplemented by weak inter-layer couplings. The possibility to tune SrCu$_2$(BO$_3$)$_2$ between the plaquette-singlet and antiferromagnetic states opens opportunities for experimental tests of quantum field theories and lattice models involving fractionalized excitations, emergent symmetries, and gauge fluctuations.Comment: 6 pages + 8 pages supplemental informatio

Analisis Kesulitan Anak Berkebutuhan Khusus Dalam Belajar Matematka Di Kelas Inklusi (Penelitian Dilaksanakan Di SMK N 9 Surakarta)

Penelitian ini bertujuan untuk mengetahui kesulitan yang dialami oleh anak berkebutuhan khusus (ABK) dalam belajar matematika di kelas inklusi. Informan dalam penelitian ini adalah siswa ABK SMK N 9 Surakarta. Data dikumpulkan dengan metode wawancara, observasi dan angket sebagai metode pokok. Metode bantu berupa dokumentasi. Analisis data kualitatif melalui 4 alur yaitu pengumpulan data, reduksi data, display data, menarik kesimpulan. Hasil penelitian menunjukan bahwa setiap ABK mengalami kesulitan dalam belajar matematika di kelas inklusi, kesulitan ABK bervariasi sesuai dengan kebutuhan mereka, bagi ABK tuna wicara dan tuna rungu mengalami kesulitan dalam mendengar selama pelajaran, bagi ABK diskalkulitia mengalami kesulitan dalam menghitung angka dan penerapan dalam soal matematika, ABK yang ber IQ rendah kesulitan dalam memahami materi yang diberikan oleh guru, Ada juga yang mengalami kesulitan belajar karena strategi pembelajaran di kelas sangat membosankan, dan guru tidak memberikan penjelasan lebih lanjut tentang materi yang dipelajari, guru hanya memberikan rumus. Guru juga tidak memberikan perlakuan khusus untuk ABK