28 research outputs found
A survey of parametric modelling methods for designing the head of a high-speed train
With the continuous increase of the running speed, the head shape of the high-speed train (HST) turns
out to be a critical factor for further speed boost. In order to cut down the time used in the HST head design and improve the modelling efficiency, various parametric modelling methods have been widely applied in the optimization design of the HST head to obtain an optimal head shape so that the aerodynamic effect acting on the head of HSTs can be reduced and more energy can be saved. This paper reviews these parametric modelling methods and classifies them into four categories: 2D, 3D, CATIA-based, and mesh deformation-based parametric modelling methods. Each of the methods is introduced, and the advantages and disadvantages of these methods are identified. The simulation results are presented to demonstrate that the aerodynamic performance of the optimal models constructed by these parametric modelling methods has been improved when compared with numerical calculation results of the original models or the prototype models of running trains. Since different parametric modelling methods used different original models and optimization methods, few publications could be found which compare the simulation results of the aerodynamic performance among different parametric modelling methods. In spite of this, these parametric modelling methods indicate more local shape details will lead to more accurate simulation results, and fewer design variables will result in higher computational efficiency. Therefore, the ability of describing more local shape details with fewer design variables could serve as a main specification to assess the performance of various parametric modelling methods. The future research directions may concentrate on how to improve such ability
Assessment of nitrate leakage and N2O emission from five environmental-friendly agricultural practices using fuzzy logic method and empirical formula
Unresolved inflammation during hospitalization is associated with post-discharge institutionalization and mortality in geriatric rehabilitation inpatients: The RESORT cohort
10.1016/j.exger.2021.111597Experimental Gerontology15611159
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Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels
Human embryonic stem cells (hESCs) is a potential unlimited ex vivo source of ventricular (V) cardiomyocytes (CMs), but hESC-VCMs and their engineered tissues display immature traits. In adult VCMs, sarcolemmal (sarc) and mitochondrial (mito) ATP-sensitive potassium (KATP) channels play crucial roles in excitability and cardioprotection. In this study, we aim to investigate the biological roles and use of sarcKATP and mitoKATP in hESC-VCM. We showed that SarcIK, ATP in single hESC-VCMs was dormant under baseline conditions, but became markedly activated by cyanide (CN) or the known opener P1075 with a current density that was ~8-fold smaller than adult; These effects were reversible upon washout or the addition of GLI or HMR1098. Interestingly, sarcIK, ATP displayed a ~3-fold increase after treatment with hypoxia (5% O2). MitoIK, ATP was absent in hESC-VCMs. However, the thyroid hormone T3 up-regulated mitoIK, ATP, conferring diazoxide protective effect on T3-treated hESC-VCMs. When assessed using a multi-cellular engineered 3D ventricular cardiac micro-tissue (hvCMT) system, T3 substantially enhanced the developed tension by 3-folds. Diazoxide also attenuated the decrease in contractility induced by simulated ischemia (1% O2). We conclude that hypoxia and T3 enhance the functionality of hESC-VCMs and their engineered tissues by selectively acting on sarc and mitoIK, ATP
Superoxide generation and leukocyte accumulation:key elements in the mediation of leukotriene B₄-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1
A role for TRPV1 in influencing the onset of cardiovascular disease in obesity
Obesity induced by Western diets is associated with type 2 diabetes mellitus and cardiovascular diseases, although underlying mechanisms are unclear. We investigated a murine model of diet-induced obesity to determine the effect of transient potential receptor vanilloid 1 (TRPV1) deletion on hypertension and metabolic syndrome. Wild-type and TRPV1 knockout mice were fed normal or high-fat diet from 3 to 15 weeks. High-fat diet-fed mice from both genotypes became obese, with similar increases in body and adipose tissue weights. High-fat diet-fed TRPV1 knockout mice showed significantly improved handling of glucose compared with high-fat diet-fed wild-type mice. Hypertension, vascular hypertrophy, and altered nociception were observed in high-fat diet-fed wild-type but not high-fat diet-fed TRPV1 knockout mice. Wild-type, but not high-fat diet-fed TRPV1 knockout, mice demonstrated remodeling in terms of aortic vascular hypertrophy and increased heart and kidney weight, although resistance vessel responses were similar in each. Moreover, the wild-type mice had significantly increased plasma levels of leptin, interleukin 10 and interleukin 1β, whereas samples from TRPV1 knockout mice did not show significant increases. Our results do not support the concept that TRPV1 plays a major role in influencing weight gain. However, we identified a role of TRPV1 in the deleterious effects observed with high-fat feeding in terms of inducing hypertension, impairing thermal nociception sensitivity, and reducing glucose tolerance. The observation of raised levels of adipokines in wild-type but not TRPV1 knockout mice is in keeping with TRPV1 involvement in stimulating the proinflammatory network that is central to obesity-induced hypertension and sensory neuronal dysfunction.</jats:p
Charge-assisted Hydrogen-bonded Linear Second-sphere Assemblies MII(DABP)3]3[Cr(C2O4)3]2·14H2O (M=Cu, Ni, Fe, Zn, and Mn) with a Discrete (H2O)14 Cluster of S6 Symmetry
TRPV1 deletion enhances local inflammation and accelerates the onset of Systemic Inflammatory Response Syndrome
Abstract
The transient receptor potential vanilloid 1 (TRPV1) is primarily localized to sensory nerve fibers and is associated with the stimulation of pain and inflammation. TRPV1 knockout (TRPV1KO) mice show enhanced LPS-induced sepsis compared with wild type (WT). This implies that TRPV1 may have a key modulatory role in increasing the beneficial and reducing the harmful components in sepsis. We investigated immune and inflammatory mechanisms in a cecal ligation and puncture (CLP) model of sepsis over 24 h. CLP TRPV1KO mice exhibited significant hypothermia, hypotension, and organ dysfunction compared with CLP WT mice. Analysis of the inflammatory responses at the site of initial infection (peritoneal cavity) revealed that CLP TRPV1KO mice exhibited: 1) decreased mononuclear cell integrity associated with apoptosis, 2) decreased macrophage tachykinin NK1-dependent phagocytosis, 3) substantially decreased levels of nitrite (indicative of NO) and reactive oxygen species, 4) increased cytokine levels, and 5) decreased bacteria clearance when compared with CLP WT mice. Therefore, TRPV1 deletion is associated with impaired macrophage-associated defense mechanisms. Thus, TRPV1 acts to protect against the damaging impact of sepsis and may influence the transition from local to a systemic inflammatory state.</jats:p