The genetics of diabetes: What we can learn from Drosophila

Diabetes mellitus is a heterogeneous disease characterized by hyperglycemia due to impaired insulin secretion and/or action. All diabetes types have a strong genetic component. The most frequent forms, type 1 diabetes (T1D), type 2 diabetes (T2D) and gestational diabetes mellitus (GDM), are multifactorial syndromes associated with several genes’ effects together with environmental factors. Conversely, rare forms, neonatal diabetes mellitus (NDM) and maturity onset diabetes of the young (MODY), are caused by mutations in single genes. Large scale genome screenings led to the identification of hundreds of putative causative genes for multigenic diabetes, but all the loci identified so far explain only a small proportion of heritability. Nevertheless, several recent studies allowed not only the identification of some genes as causative, but also as putative targets of new drugs. Although monogenic forms of diabetes are the most suited to perform a precision approach and allow an accurate diagnosis, at least 80% of all monogenic cases remain still undiag-nosed. The knowledge acquired so far addresses the future work towards a study more focused on the identification of diabetes causal variants; this aim will be reached only by combining expertise from different areas. In this perspective, model organism research is crucial. This review traces an overview of the genetics of diabetes and mainly focuses on Drosophila as a model system, describing how flies can contribute to diabetes knowledge advancement

A quasi-static nonlinear analysis for assessing the fire resistance of 3d frames exploiting time-dependent yield surface

In this work an automatic procedure for evaluating the axial force-biaxial bending yield surface of reinforced concrete sections in fire is proposed. It provides an accurate time-dependent expression of the yield condition by a section analysis carried out once and for all, accounting for the strength reduction of the materials, which is a function of the fire duration. The equilibrium state of 3D frames with such yield conditions, once discretized using beam finite elements, is formulated as a nonlinear vectorial equation defining a curve in the hyperspace of the discrete variables and the fire duration. A generalized path-following strategy is proposed for tracing this curve and evaluating, if it exists, the limit fire duration, that is the time of exposure which leads to structural collapse. Compared to the previous proposals on the topic, which are limited to local sectional checks, this work is the first to present a global analysis for assessing the fire resistance of 3D frames, providing a time history of the fire event and taking account of the stress redistribution. Numerical examples are given to illustrate and validate the proposal

CMB lensing extraction and primordial non-Gaussianity

The next generation of CMB experiments should get a better handle on cosmological parameters by mapping the weak lensing deflection field, which is separable from primary anisotropies thanks to the non-Gaussianity induced by lensing. However, the generation of perturbations in the Early Universe also produces a level of non-Gaussianity which is known to be small, but can contribute to the anisotropy trispectrum at the same level as lensing. In this work, we study whether the primordial non-Gaussianity can mask the lensing statistics. We concentrate only on the ``temperature quadratic estimator'' of lensing, which will be nearly optimal for the Planck satellite, and work in the flat-sky approximation. We find that primordial non-Gaussianity contaminates the deflection field estimator by roughly (0.1 f_NL)% at large angular scales, which represents at most a 10% contribution, not sufficient to threaten lensing extraction, but enough to be taken into account.Comment: 5 pages, 1 figur

Nosocomial Candida infections: epidemiology of candidaemia

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Calculating the local-type fNL for slow-roll inflation with a non-vacuum initial state

Single-field slow-roll inflation with a non-vacuum initial state has an enhanced bispectrum in the local limit. We numerically calculate the local-type fNL signal in the CMB that would be measured for such models (including the full transfer function and 2D projection). The nature of the result depends on several parameters, including the occupation number N_k, the phase angle \theta_k between the Bogoliubov parameters, and the slow-roll parameter \epsilon. In the most conservative case, where one takes \theta_k \approx \eta_0 k (justified by physical reasons discussed within) and \epsilon\lesssim 0.01, we find that 0 < fNL < 1.52 (\epsilon/0.01), which is likely too small to be detected in the CMB. However, if one is willing to allow a constant value for the phase angle \theta_k and N_k=O(1), fNL can be much larger and/or negative (depending on the choice of \theta_k), e.g. fNL \approx 28 (\epsilon/0.01) or -6.4 (\epsilon/0.01); depending on \epsilon, these scenarios could be detected by Planck or a future satellite. While we show that these results are not actually a violation of the single-field consistency relation, they do produce a value for fNL that is considerably larger than that usually predicted from single-field inflation.Comment: 8 pages, 1 figure. v2: Version accepted for publication in PRD. Added greatly expanded discussion of the phase angle \theta_k; this allows the possibility of enhanced fNL, as mentioned in abstract. More explicit comparisons with earlier wor

Environmental microbial contamination in dental setting: a local experience

ntroduction. Patients and operators are exposed during dental practice to an infective risk, which derives especially from micro- organisms suspended in aerosols. Environmental microbiologi- cal monitoring in dental settings represents a good instrument to detect critical situations. Methods. In order to investigate environmental microbial contami- nation level in a local reality, we analyzed water, air and surfaces samples of a community-based dental facility by using protocol and threshold values proposed in a recent multicenter study carried out by the Italian Society of Hygiene, Preventive Medicine and Public Health (S.It.I.) working group ?Hygiene in Dentistry?. Microbial contamination was assessed in the same room for 4 non-consecu- tive weeks during all the five working days, before and at the end of the daily activity. Air was sampled also during clinical activity, through both active and passive sampling systems. Results. Contamination of water showed a decrease during activ- ities, while a decrease in air contamination was registered only at the end of the day. Passive sampling values resulted more often above threshold values adopted. At the same time, surfaces con- tamination increases at the end of the activity. It seems that in the dental clinic analyzed microbial buildup represents the higher critical element. No differences have been registered among the different days of the week. Discussion. Our study highlights the need to improve disinfection procedures and air treatment systems in the considered environ- ment. Microbiological monitoring could represent an important element to detect the presence of risk factors and to adopt control measures

Are health literacy and lifestyle of undergraduates related to the educational field? An italian survey

Background: Health literacy (HL) is a fundamental ability to successfully deal with health and illness issues. This study aimed to assess HL among undergraduates from healthcare and non-healthcare degree courses of two Italian universities and the association between their HL, lifestyles, and BMI assumed as health outcome. Methods: The Health Literacy Assessment Tool (HLAT-8) and the Newest Vital Sign (NVS) were used to assess health literacy dimensions. Demographic and anthropometric data, adherence to Mediterranean diet (MD), physical activity levels, and smoking habits were assessed in the enrolled sample to highlight possible associations. Results: A total sample of 806 undergraduates (46% males, mean age 21.01 ± 1.78 years) was recruited. Higher HL scores were found among healthcare rather than non-healthcare students (28.7 ± 4.5 vs. 26.7 ± 4.2 for HLAT-8 and 4.9 ± 1.5 vs. 3.9 ± 1.8 for NVS, p &lt; 0.01). However, healthcare undergraduates were more likely to report unhealthy behaviors. Body Mass Index (BMI) was associated with literacy and numeracy skills only in non-healthcare undergraduates. Significant associations were found between HL scores and adherence to MD in both groups. In the regression analysis, educational field and MD were shown to be predictors of HL scores. Conclusions: Attending a healthcare related degree course was associated with higher HL scores but not with healthy behaviors. This issue should be addressed considering the role that healthcare professionals may have in educating patients towards a healthy lifestyle. Adherence to MD seems to be related to higher HL scores

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

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