A forensic geoscience framework and practice

Appropriate and correct collection, analysis, interpretation, and presentation of geoforensic evidence are contingent upon understanding the specific context of the particular forensic investigation undertaken. To achieve this, the role of experimental studies in forensic geoscience must not be underestimated. In this article, we present two experimental studies that assess the spatial distribution of pollen in a living room and the nature of subsequent transfer of pollen onto clothing. The presence of cut flowers in a living room are shown to lead to a distribution of pollen grains onto all types of surface in that room that exhibits a distance–decay pattern with the greatest numbers of grains found in close proximity to the flowers. Once the transfer of pollen grains from a source location onto clothing has taken place, our second study demonstrates the nature of the persistence of that evidence for dry and damp clothing under active and inactive conditions. The level of activity after transfer is shown to have far more influence upon the persistence of this form of geoforensic evidence in comparison to the damp or dry conditions of the garment. We argue that these findings have implications for all stages of the forensic investigation–from sampling protocols to the interpretation of the presence/absence of geoforensic evidence. Whilst every contact does indeed leave a trace, it is imperative that there is an appreciation of the context of each forensic investigation, meaningful science take place and accurate and helpful crime reconstructions to be achieved

Flujos atrioventriculares normales evaluados por la técnica Doppler espectral en caninos

Los autores realizaron un estudio de las posiciones más adecuadas para estudiar los flujos transmitral y transtricuspídeo por medio de Doppler espectral pulsado en caninos normales y determinar los valores medios de los siguientes parámetros: velocidad pico, velocidad media, gradiente pico de presión, gradiente medio de presión, integral tiempo–velocidad y relación entre ondas E y A. Las mejores posiciones para la obtención de valores del flujo mitral y tricuspídeo fueron la imagen apical de cinco cámaras captada desde la ventana paraesternal izquierda para la primera y la oblicua del tracto de entrada ventricular derecho en la misma ventana para la segunda

Noninvasive positive pressure ventilation for acute respiratory failure in children: a concise review

Noninvasive positive pressure ventilation (NPPV) refers to the delivery of mechanical respiratory support without the use of endotracheal intubation (ETI). The present review focused on the effectiveness of NPPV in children > 1 month of age with acute respiratory failure (ARF) due to different conditions. ARF is the most common cause of cardiac arrest in children. Therefore, prompt recognition and treatment of pediatric patients with pending respiratory failure can be lifesaving. Mechanical respiratory support is a critical intervention in many cases of ARF. In recent years, NPPV has been proposed as a valuable alternative to invasive mechanical ventilation (IMV) in this acute setting. Recent physiological studies have demonstrated beneficial effects of NPPV in children with ARF. Several pediatric clinical studies, the majority of which were noncontrolled or case series and of small size, have suggested the effectiveness of NPPV in the treatment of ARF due to acute airway (upper or lower) obstruction or certain primary parenchymal lung disease, and in specific circumstances, such as postoperative or postextubation ARF, immunocompromised patients with ARF, or as a means to facilitate extubation. NPPV was well tolerated with rare major complications and was associated with improved gas exchange, decreased work of breathing, and ETI avoidance in 22-100% of patients. High FiO2 needs or high PaCO2 level on admission or within the first hours after starting NPPV appeared to be the best independent predictive factors for the NPPV failure in children with ARF. However, many important issues, such as the identification of the patient, the right time for NPPV application, and the appropriate setting, are still lacking. Further randomized, controlled trials that address these issues in children with ARF are recommended

Vegan diets : practical advice for athletes and exercisers.

With the growth of social media as a platform to share information, veganism is becoming more visible, and could be becoming more accepted in sports and in the health and fitness industry. However, to date, there appears to be a lack of literature that discusses how to manage vegan diets for athletic purposes. This article attempted to review literature in order to provide recommendations for how to construct a vegan diet for athletes and exercisers. While little data could be found in the sports nutrition literature specifically, it was revealed elsewhere that veganism creates challenges that need to be accounted for when designing a nutritious diet. This included the sufficiency of energy and protein; the adequacy of vitamin B12, iron, zinc, calcium, iodine and vitamin D; and the lack of the long-chain n-3 fatty acids EPA and DHA in most plant-based sources. However, via the strategic management of food and appropriate supplementation, it is the contention of this article that a nutritive vegan diet can be designed to achieve the dietary needs of most athletes satisfactorily. Further, it was suggested here that creatine and β-alanine supplementation might be of particular use to vegan athletes, owing to vegetarian diets promoting lower muscle creatine and lower muscle carnosine levels in consumers. Empirical research is needed to examine the effects of vegan diets in athletic populations however, especially if this movement grows in popularity, to ensure that the health and performance of athletic vegans is optimised in accordance with developments in sports nutrition knowledge

Models of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a major global health problem and is predicted to become the third most common cause of death by 2020. Apart from the important preventive steps of smoking cessation, there are no other specific treatments for COPD that are as effective in reversing the condition, and therefore there is a need to understand the pathophysiological mechanisms that could lead to new therapeutic strategies. The development of experimental models will help to dissect these mechanisms at the cellular and molecular level. COPD is a disease characterized by progressive airflow obstruction of the peripheral airways, associated with lung inflammation, emphysema and mucus hypersecretion. Different approaches to mimic COPD have been developed but are limited in comparison to models of allergic asthma. COPD models usually do not mimic the major features of human COPD and are commonly based on the induction of COPD-like lesions in the lungs and airways using noxious inhalants such as tobacco smoke, nitrogen dioxide, or sulfur dioxide. Depending on the duration and intensity of exposure, these noxious stimuli induce signs of chronic inflammation and airway remodelling. Emphysema can be achieved by combining such exposure with instillation of tissue-degrading enzymes. Other approaches are based on genetically-targeted mice which develop COPD-like lesions with emphysema, and such mice provide deep insights into pathophysiological mechanisms. Future approaches should aim to mimic irreversible airflow obstruction, associated with cough and sputum production, with the possibility of inducing exacerbations