Linguistics

Contains reports on one research project.National Science Foundation (Grant GP-2495)National Institutes of Health (Grant MH-04737-05)National Aeronautics and Space Administration (Grant NsG-496)U. S. Air Force (Electronic Systems Division) under Contract AF 19(628)- 248

Linguistics

Contains research objectives and reports on three research projects.National Science Foundation (Grant GP-2495)National Institutes of Health (Grant MH-04737-04)National Aeronautics and Space Administration (Grant NsG-496)U. S. Air Force (Electronic Systems Division) under Contract AF19(628)-248

Linguistics

Contains reports on three research projects.National Science Foundation (Grant GP-2495)National Institutes of Health (Grant MH-04737-04)U. S. Air Force. Electronics Systems Division (Contract AFl9(628)-2487)National Aeronautics and Space Administration (Grant NsG-496

Linguistics

Contains reports on six research projects.National Institutes of Health (Grant MH-04737-03)National Science Foundation (Grant G-16526)National Aeronautics and Space Administration (Grant NsG-496)United States Air Force, Electronic Systems Division (Contract AF19(628)-2487

Linguistics

Contains reports on seven research projects.National Science Foundation (Grant G-16526)National Institutes of Health (Grant MH-04737-02)United States Air Force, Electronic Systems Division (Contract AF19(628)-2487

Linguistics

Contains reports on seven research projects.National Science Foundation (Grant G-16526)National Institutes of Health (Grant MH-04737-03)U. S. Air Force (Electronics Systems Division) under Contract AF19(628)-248

Seeking Abraham: A Report of Furman University\u27s Task Force on Slavery and Justice

After more than a year of study, the Furman University Task Force on Slavery and Justice presents its findings in this report. The report includes the Task Force’s values and process, a presentation of the history of Furman’s early ties to slavery, a number of short vignettes by individual Task Force members, and a number of recommendations for the university to address. Members of the Task Force represent diverse students and alumni, as well as faculty and staff. The report is the result of commissioning a history, activating student research projects, hosting scholars who consulted with the Task Force, creating oral histories and curating viewpoints, and attending Universities Studying Slavery, a consortium headquartered at the University of Virginia with more than 40 international colleges and universities. The university has made a commitment to serious consideration of the entire report

Bright ligand-activatable fluorescent protein for high-quality multicolor live-cell super-resolution microscopy

We introduce UnaG as a green-to-dark photoswitching fluorescent protein capable of high-quality super-resolution imaging with photon numbers equivalent to the brightest photoswitchable red protein. UnaG only fluoresces upon binding of a fluorogenic metabolite, bilirubin, enabling UV-free reversible photoswitching with easily controllable kinetics and low background under Epi illumination. The on- and off-switching rates are controlled by the concentration of the ligand and the excitation light intensity, respectively, where the dissolved oxygen also promotes the off-switching. The photo-oxidation reaction mechanism of bilirubin in UnaG suggests that the lack of ligand-protein covalent bond allows the oxidized ligand to detach from the protein, emptying the binding cavity for rebinding to a fresh ligand molecule. We demonstrate super-resolution single-molecule localization imaging of various subcellular structures genetically encoded with UnaG, which enables facile labeling and simultaneous multicolor imaging of live cells. UnaG has the promise of becoming a default protein for high-performance super-resolution imaging. Photoconvertible proteins occupy two color channels thereby limiting multicolour localisation microscopy applications. Here the authors present UnaG, a new green-to-dark photoswitching fluorescent protein for super-resolution imaging, whose activation is based on a noncovalent binding with bilirubin

Genetic Signature of Rapid IHHNV (Infectious Hypodermal and Hematopoietic Necrosis Virus) Expansion in Wild Penaeus Shrimp Populations

Infectious hypodermal and hematopoietic necrosis virus (IHHNV) is a widely distributed single-stranded DNA parvovirus that has been responsible for major losses in wild and farmed penaeid shrimp populations on the northwestern Pacific coast of Mexico since the early 1990's. IHHNV has been considered a slow-evolving, stable virus because shrimp populations in this region have recovered to pre-epizootic levels, and limited nucleotide variation has been found in a small number of IHHNV isolates studied from this region. To gain insight into IHHNV evolutionary and population dynamics, we analyzed IHHNV capsid protein gene sequences from 89 Penaeus shrimp, along with 14 previously published sequences. Using Bayesian coalescent approaches, we calculated a mean rate of nucleotide substitution for IHHNV that was unexpectedly high (1.39×10−4 substitutions/site/year) and comparable to that reported for RNA viruses. We found more genetic diversity than previously reported for IHHNV isolates and highly significant subdivision among the viral populations in Mexican waters. Past changes in effective number of infections that we infer from Bayesian skyline plots closely correspond to IHHNV epizootiological historical records. Given the high evolutionary rate and the observed regional isolation of IHHNV in shrimp populations in the Gulf of California, we suggest regular monitoring of wild and farmed shrimp and restriction of shrimp movement as preventative measures for future viral outbreaks

Seeking Abraham: A Report of Furman University\u27s Task Force on Slavery and Justice. Second Edition

This second edition of the Seeking Abraham Report includes additional appendices, such as Appendix B, the Special Committee on Slavery and Justice’s Report to the Board of Trustees. The Special Committee’s recommendations were accepted unanimously by the Board, meaning that the university will begin to implement a version of the key campus grounds recommendations of the report in the 2019-2020 academic year