Variational blue noise sampling

Blue noise point sampling is one of the core algorithms in computer graphics. In this paper, we present a new and versatile variational framework for generating point distributions with high-quality blue noise characteristics while precisely adapting to given density functions. Different from previous approaches based on discrete settings of capacity-constrained Voronoi tessellation, we cast the blue noise sampling generation as a variational problem with continuous settings. Based on an accurate evaluation of the gradient of an energy function, an efficient optimization is developed which delivers significantly faster performance than the previous optimization-based methods. Our framework can easily be extended to generating blue noise point samples on manifold surfaces and for multi-class sampling. The optimization formulation also allows us to naturally deal with dynamic domains, such as deformable surfaces, and to yield blue noise samplings with temporal coherence. We present experimental results to validate the efficacy of our variational framework. Finally, we show a variety of applications of the proposed methods, including nonphotorealistic image stippling, color stippling, and blue noise sampling on deformable surfaces. © 1995-2012 IEEE.published_or_final_versio

Recycling spent lead-acid battery into lead halide for resource purification and multifunctional perovskite diode

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of aficamten in healthy Chinese participants: a randomized, double-blind, placebo-controlled, phase 1 study

Objectives: Aficamten is a selective, small-molecule allosteric inhibitor of cardiac sarcomere being developed as a chronic oral treatment for patients with symptomatic obstructive hypertrophic cardiomyopathy. This was the first-in-Chinese study aiming to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of aficamten in healthy adults.Methods: This double-blind, randomized, placebo-controlled, phase 1 study was conducted in 28 healthy male and female Chinese participants after single ascending dose (SAD) and multi-dose (MD) administrations of aficamten. In the SAD cohort, 16 participants were randomized to receive a single oral dose of aficamten: 10 mg, 20 mg, or placebo. In the MD cohort, 12 participants were randomized to receive multiple doses of aficamten: 5 mg or placebo once daily for 14 days. Safety was monitored throughout the study with electrocardiograms, echocardiograms, clinical laboratory tests, and reporting of adverse events (AEs). Pharmacokinetic profiles of aficamten and metabolites, as well as CYP2D6 genetic impact, were evaluated.Results: A total of 35 treatment-emergent AEs were reported by 14 (50%) participants with mild severity. There were no serious AEs or adverse decreases in left ventricular ejection fraction below 50% during the study. Aficamten was dose-proportional over the dose range of 5–20 mg and accumulated in the MD cohort.Conclusion: Aficamten was safe and well-tolerated in the healthy Chinese adult participants. The pharmacokinetics of aficamten in the Chinese population was comparable to those previously found in Western participants. These phase 1 data support the progression of aficamten into future clinical studies in Chinese patients.Clinical Trial registration:https://clinicaltrials.gov, identifier: NCT04783766

A Novel Testis-specific GTPase Serves as a Link to Proteasome Biogenesis: Functional Characterization of RhoS/RSA-14-44 in Spermatogenesis

We functionally characterized RhoS/RSA-14-44 as a new member of Rho GTPase subfamily in spermatogenesis, which provides a direct link between Rho family GTPase and the proteasome biogenesis

Autophagy: A Double-Edged Sword in Male Reproduction

Autophagy, an evolutionarily conserved cell reprogramming mechanism, exists in all eukaryotic organisms. It is a fundamental and vital degradation/recycling pathway that removes undesirable components, such as cytoplasmic organelles, misfolded proteins, viruses, and intracellular bacteria, to provide energy and essential materials for organisms. The success of male reproduction depends on healthy testes, which are mainly composed of seminiferous tubules and mesenchyme. Seminiferous tubules are composed of Sertoli cells (SCs) and various germ cells, and the main functional part of mesenchyme are Leydig cells (LCs). In recent years, a large amount of evidence has confirmed that autophagy is active in many cellular events associated with the testes. Autophagy is not only important for testicular spermatogenesis, but is also an essential regulatory mechanism for the ectoplasmic specialization (ES) integrity of SCs, as well as for the normal function of the blood–testes barrier (BTB). At the same time, it is active in LCs and is crucial for steroid production and for maintaining testosterone levels. In this review, we expanded upon the narration regarding the composition of the testes; summarized the regulation and molecular mechanism of autophagy in SCs, germ cells, and LCs; and concluded the roles of autophagy in the process of spermatogenesis and testicular endocrinology. Through integrating the latest summaries and advances, we discuss how the role of autophagy is a double-edged sword in the testes and may provide insight for future studies and explorations on autophagy in male reproduction

Wear monitoring of diamond saw wire based on YOLOv5 and DeepSORT

In order to improve the efficiency and quality of diamond wire saw cutting and meet the demand of real-time monitoring of saw wire wear, a detection algorithm based on improved YOLOv5 was proposed. The algorithm combined coordinate attention mechanism and BiFPN module on the basis of YOLOv5. The detection accuracy, recall rate and average accuracy were increased by 1.7%, 3.7% and 3.2% respectively. Abrasive particles with different wear degrees can be effectively detected. Besides, the DeepSORT multi-target tracking algorithm was connected to set up a virtual detection line, count the number of abrasive particles with different wear degrees, and monitor the wear of diamond saw wire