In Memorian Sir John Harington of Kelson (1561-1612)

No abstrac

Loss of Memo, a novel FGFR regulator, results in reduced lifespan.

Memo is a widely expressed 33-kDa protein required for heregulin (HRG)-, epidermal growth factor (EGF)-, and fibroblast growth factor (FGF)-induced cell motility. Studies in mouse embryonic fibroblasts, wild-type or knockout for Memo, were performed to further investigate the role of Memo downstream of FGFR. We demonstrated that Memo associates with the FGFR signalosome and is necessary for optimal activation of signaling. To uncover Memo's physiological role, Memo conditional-knockout mice were generated. These animals showed a reduced life span, increased insulin sensitivity, small stature, graying hair, alopecia, kyphosis, loss of subcutaneous fat, and loss of spermatozoa in the epididymis. Memo-knockout mice also have elevated serum levels of active vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D), and calcium compared to control littermates expressing Memo. In summary, the results from in vivo and in vitro models support the hypothesis that Memo is a novel regulator of FGFR signaling with a role in controlling 1,25(OH)2D production and normal calcium homeostasis

Prevalence of double (Fused/Geminated) primary teeth in Turkey – A study

In this paper, an intelligent and automatic moving object edge detection algorithm is proposed, based on heat flow analogy. This algorithm starts with anisotropic heat diffusion in the spatial domain to remove noise and sharpen region boundaries for the purpose of obtaining high quality edge data. Then, isotropic heat diffusion is applied in the temporal domain to calculate the total amount of heat flow. The moving edges are represented as the total amount of heat flow out from the reference frame. The overall process is completed by non-maxima suppression and hysteresis thresholding to obtain binary moving edges. Evaluation results indicate that this approach has advantages in handling noise in the temporal domain because of the averaging inherent of isotropic heat flow. Results also show that this technique can detect moving edges in image sequences

Experimental method for complex thermo-mechanical material analysis

An experimental system for complex thermo-mechanical material analysis is presented in this article. The system provides simultaneous measurements of tensile properties as well as heat generation in the process of tensile deformation. The cooling curve of the sample after its reversible deformation was measured. On the basis of an exponential model of a cooling body with respect to the Biot number Bi, it is possible to calculate the specific heat capacity c p , the thermal diffusivity α, and the thermal conductivity k. The method had been tested on a variety of materials and the results were compared to those in the technical literature or obtained by reference independent experiments and showed very good agreement