Transdermal β-Blocker Therapy in Essential Hypertension

Transdermal drug delivery has been applied to various agents in an effort to decrease the frequency of drug administration and increase the patients compliance. In our study, we demonstrated that transdermal application of a ß-blocker (20 mg mepindolol) in patients with essential hypertension led to effective blood pressure lowering effect within 1 week (160.1 ±6.1 mm Hg/95.8 ± 8.3 mm Hg vs 136.8 ± 7.2 mm Hg/84.3 ± 5.0 mm Hg; Ρ < 0.05). A controlled study of transdermal versus oral ß-blocker administration in hypertensives is necessary before this new therapeutic system is introduced in antihypertensive treatment. Am J Hypertens 1988; 1:199S-200

Влияние асфальтенов, смол и парафинов на реологические свойства нефтей различных месторождений

Аномальность в поведении нефтей некоторых месторождений является следствием наличия в них сложных структурных единиц, придающие таким нефтям специфические реологические свойства и заметно отличающие их от обычных жидкостей. Изучение поведения аномальных нефтей является актуальной проблемой нефтяной отрасли, так как это путь к повышению эффективности эксплуатации скважин, поскольку при разработки месторождений такого типа нефтей эксплуатации осложняется проявлением аномалий вязкости и подвижности нефти, образованием АСПО и высоковязких эмульсий в призабойной зоне пласта. Основная цель работы - разработка научно-технологических способов регулирования реологических свойств высоковязких нефтей с неньютоновскими свойствами для оптимизации процессов добычи и транспорта по трубопроводам.Learning of the behavior of anomalous oils is an urgent problem in the oil industry, because it is the way to increase the efficiency of well operation. Indeed, development of deposits of this type of oil is complicated by the manifestation of viscosity anomalies and oil mobility due to the formation of AFS and high-viscosity emulsions in the bottomhole formation zone. The urgency of the problem is growing because of the share of hard-to-recover oil has grown substantially over the past decade in the structure of Russian reserves. The main objective of this paper - development of scientific and technological methods for regulating the rheological properties of high-viscosity oils with non-Newtonian properties for optimization of production and transport processes through pipelines

Interdomain Interactions Control Ca2+-Dependent Potentiation in the Cation Channel TRPV4

Several Ca2+-permeable channels, including the non-selective cation channel TRPV4, are subject to Ca2+-dependent facilitation. Although it has been clearly demonstrated in functional experiments that calmodulin (CaM) binding to intracellular domains of TRP channels is involved in this process, the molecular mechanism remains elusive. In this study, we provide experimental evidence for a comprehensive molecular model that explains Ca2+-dependent facilitation of TRPV4. In the resting state, an intracellular domain from the channel N terminus forms an autoinhibitory complex with a C-terminal domain that includes a high-affinity CaM binding site. CaM binding, secondary to rises in intracellular Ca2+, displaces the N-terminal domain which may then form a homologous interaction with an identical domain from a second subunit. This represents a novel potentiation mechanism that may also be relevant in other Ca2+-permeable channels

A European City? The Making of Modern Athens, 1830‐1970

This article outlines the urban development of Athens between the 1830s and 1970s and by doing so questions the validity of the concept of the “European City” by concentrating on a Southern European example. It proposes a more inclusive view of European urbanisation by drawing attention to the social phenomenon of clientelism as an element of civil society and as a major factor in the development of the urban environment.13 p

Jüdisches Mäzenatentum im Frankreich des 19. Und 20 jahrunderts. Aus dem privaten in de öffentlichen Raum »

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