102 research outputs found
Strong Gravitational Lensing in a Charged Squashed Kaluza- Klein Black hole
In this paper we investigate the strong gravitational lensing in a charged
squashed Kaluza-Klein black hole. We suppose that the supermassive black hole
in the galaxy center can be considered by a charged squashed Kaluza-Klein black
hole and then we study the strong gravitational lensing theory and estimate the
numerical values for parameters and observables of it. We explore the effects
of the scale of extra dimension and the charge of black hole
on these parameters and observables.Comment: 17 pages, 10 figure
Microlensing as a probe of the Galactic structure; 20 years of microlensing optical depth studies
Microlensing is now a very popular observational astronomical technique. The
investigations accessible through this effect range from the dark matter
problem to the search for extra-solar planets. In this review, the techniques
to search for microlensing effects and to determine optical depths through the
monitoring of large samples of stars will be described. The consequences of the
published results on the knowledge of the Milky-Way structure and its dark
matter component will be discussed. The difficulties and limitations of the
ongoing programs and the perspectives of the microlensing optical depth
technique as a probe of the Galaxy structure will also be detailed.Comment: Accepted for publication in General Relativity and Gravitation.
General Relativity and Gravitation in press (2010) 0
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Foreign policy and globalization theory: The case of Israel
Since the early 1990s, international relations has witnessed a stimulating debate on globalization. This debate laid the foundations for globalization theory (GT), providing the tools for an empirical examination of the globalization of multiple activities: from politics and organized violence, to finance, trade and production, through culture and environmental degradation. However, examination of what appear to be the best-known works on globalization reveals that foreign policy has been virtually excluded from GT. In this context, based on what is described here as a synergistic transformationalist approach (STA) to globalization, I provide a critique of GT. The critique is geared towards examining why foreign policy hitherto has been overlooked by contemporary GT. I expose the problems this generates and address them by exploring how STA enables GT to incorporate foreign policy. I use the case of Israel heuristically to elicit how incorporating foreign policy into GT may provide a better understanding of the relationship between foreign policy and globalization. Three themes are highlighted: the role of foreign policy in inducing and reproducing globalization; determining the mutually constitutive relationship between globalization and the state; and shaping the interfacing between international politics and globalization
Active/Passive, ‘Diminished’/‘Beautiful’, ‘Light’ from Above and Below: Rereading Shekhinah’s Sexual Desire in Zohar al Shir ha-Shirim (Song of Songs)
In Zohar al Shir ha-Shirim, the Zohar’s reading of Song of Songs, Shekhinah, echoing themes associated with the Shulamite of the biblical text, consistently initiates cosmic union. Sexual desire in the zoharic texts is a form of capital necessary to facilitate sefirotic intercourse, although scholarly readings of the zoharic corpus often identify Shekhinah as a passive receptacle. This, however, is only true if the endemic contradictions within the texts are glossed over. In Song of Songs, the Shulamite’s sexual ‘initiative’ is core. This was not lost on the author(s) of Zohar al Shir ha-Shirim, who, in struggling to explain Shekhinah’s sefirotic role in line with the erotics of Song of Songs, inescapably echoed the ‘depatriarchalizing’ themes of the biblical text. As this article demonstrates, in Zohar al Shir ha-Shirim, Shekhinah is active and repeatedly encourages and frustrates cosmic sexual intercourse. Zohar al Shir ha-Shirim shows that it is possible to reread Shekhinah’s role beyond the androcentrism of the authors as well as scholarly assumptions about her passivity
Study by MOA of extra-solar planets in gravitational microlensing events of high magnification
A search for extra-solar planets was carried out in three gravitational
microlensing events of high magnification, MACHO 98-BLG-35, MACHO 99-LMC-2, and
OGLE 00-BUL-12. Photometry was derived from observational images by the MOA and
OGLE groups using an image subtraction technique. For MACHO 98-BLG-35,
additional photometry derived from the MPS and PLANET groups was included.
Planetary modeling of the three events was carried out in a super-cluster
computing environment. The estimated probability for explaining the data on
MACHO 98-BLG-35 without a planet is <1%. The best planetary model has a planet
of mass ~(0.4-1.5) X 10^-5 M_Earth at a projected radius of either ~1.5 or ~2.3
AU. We show how multi-planet models can be applied to the data. We calculated
exclusion regions for the three events and found that Jupiter-mass planets can
be excluded with projected radii from as wide as about 30 AU to as close as
around 0.5 AU for MACHO 98-BLG-35 and OGLE 00-BUL-12. For MACHO 99-LMC-2, the
exclusion region extends out to around 10 AU and constitutes the first limit
placed on a planetary companion to an extragalactic star. We derive a
particularly high peak magnification of ~160 for OGLE 00-BUL-12. We discuss the
detectability of planets with masses as low as Mercury in this and similar
events.Comment: 14 pages, 16 embedded postscript figures, 3 PNG figures, revised
version accepted by MNRA
Nanopore surface coating delivers nanopore size and shape through conductance-based sizing
The performance of nanopore single-molecule sensing elements depends intimately on their physical dimensions and surface chemical properties. These factors underpin the dependence of the nanopore ionic conductance on electrolyte concentration, yet the measured, or modeled, dependence only partially illuminates the details of geometry and surface chemistry. Using the electrolyte-dependent conductance data before and after selective surface functionalization of solid-state nanopores, however, introduces more degrees of freedom and improves the performance of conductance-based nanopore characterizations. Sets of representative nanopore profiles were used to generate conductance data, and the nanopore shape and exact dimensions were identified, through conductance alone, by orders-of-magnitude 3 reductions in the geometry optimization metrics. The optimization framework could similarly be used to evaluate the nanopore surface coating thickness
Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells
<p>Abstract</p> <p>Background</p> <p>Isothiocyanates are natural compounds found in consumable cruciferous vegetables. They have been shown to inhibit chemical carcinogenesis by a wide variety of chemical carcinogens in animal models. Recent studies have also shown that isothiocyanates have antitumor activity, inhibiting the growth of several types of cultured human cancer cells. Our previous study showed that PEITC inhibited human leukemia cells growth by inducing apoptosis. However, the effect of isothiocyanates on lung cancer cell metastasis has not been studied. In the present study, we investigated the inhibitory effects of BITC and PEITC on metastatic potential of highly metastatic human lung cancer L9981 cells.</p> <p>Methods</p> <p>Cell migration and invasion were measured by wound healing assay and transwell chemotaxis assay. Expression of metastasis-related genes was assessed by quantitative RT-PCR and Western blotting. The mechanisms of action were evaluated by flow cytometry, reporter assay and Western blotting.</p> <p>Results</p> <p>Our data showed that both BITC and PEITC inhibited L9981 cell growth in a dose-dependent manner, the IC50 values were 5.0 and 9.7 μM, respectively. Cell migrations were reduced to 8.1% and 16.5% of control, respectively; and cell invasions were reduced to 2.7% and 7.3% of control, respectively. Metastasis-related genes MMP-2, Twist and β-catenin were also modulated. BITC and PEITC inhibited cell survival signaling molecules Akt and NFκB activation. Moreover, BITC and PEITC increased ROS generation and caused GSH depletion. Pretreatment with NAC blocked BITC and PEITC induced ROS elevation and NFκB inhibition.</p> <p>Conclusion</p> <p>Our results indicated that BITC and PEITC suppress lung cancer cell metastasis potential by modulation of metastasis-related gene expression, inhibition of Akt/NFκB pathway. Induction of oxidative stress may play an important role.</p
A phase I clinical trial of continual alternating etoposide and topotecan in refractory solid tumours
The goal of this phase I study was to develop a novel schedule using oral etoposide and infusional topotecan as a continually alternating schedule with potentially optimal reciprocal induction of the nontarget topoisomerase. The initial etoposide dose was 15 mg m−2 b.i.d. days (D)1–5 weeks 1,3,5,7,9 and 11, escalated 5 mg per dose per dose level (DL). Topotecan in weeks 2,4,6,8,10 and 12 was administered by 96 h infusion at an initial dose of 0.2 mg m−2 day−1 with a dose escalation of 0.1, then at 0.05 mg m−2 day−1. Eligibility criteria required no organ dysfunction. Two dose reductions or delays were allowed. A total of 36 patients with a median age of 57 (22–78) years, received a median 8 (2–19) weeks of chemotherapy. At DL 6, dose-limiting toxicities consisted of grade 3 nausea, vomiting and intolerable fatigue. Three patients developed a line-related thrombosis or infection and one subsequently developed AML. There was no febrile neutropenia. There were six radiologically confirmed responses (18%) and 56% of patients demonstrated a response or stable disease, typically with only modest toxicity. Oral etoposide 35 mg m−2 b.i.d. D1–5 and 1.8 mg m−2 96 h (total dose) infusional topotecan D8–11 can be administered on an alternating continual weekly schedule for at least 12 weeks, with promising clinical activity
Notes on Hidden Mirror World
A few remarks on Dark Matter (DM) models are presented. An example is Mirror
Matter which is the oldest but still viable DM candidate, perhaps not in the
purest form. It can serve as a test-bench for other analogous DM models, since
the properties of macroscopic objects are quite firmly fixed for Mirror Matter.
A pedagogical derivation of virial theorem is given and it is pointed out that
concepts of virial velocity or virial temperature are misleading for some
cases. It is shown that the limits on self-interaction cross-sections derived
from observations of colliding clusters of galaxies are not real limits for
individual particles if they form macroscopic bodies. The effect of the heating
of interstellar medium by Mirror Matter compact stars is very weak but may be
observable. The effect of neutron star heating by accretion of M-baryons may be
negligible. Problems of MACHOs as Mirror Matter stars are touched upon.Comment: Latex, revtex, 24 pages, 1 figure, references updated and adde
Microstructural analysis of the effects of incorporation of myelin basic protein in phospholipid layers
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