The Environment as an Argument

Context-awareness as defined in the setting of Ubiquitous Computing [3] is all about expressing the dependency of a specific computation upon some implicit piece of information. The manipulation and expression of such dependencies may thus be neatly encapsulated in a language where computations are first-class values. Perhaps surprisingly however, context-aware programming has not been explored in a functional setting, where first-class computations and higher-order functions are commonplace. In this paper we present an embedded domain-specific language (EDSL) for constructing context-aware applications in the functional programming language Haskell. © 2012 Springer-Verlag

Computer-guided concentration-controlled trials in autoimmune disorders

A randomized concentration-controlled clinical trial (RCCCT) is an alternate experimental design to the standard dose-controlled study. In a RCCCT, patients are randomly assigned to predefined plasma or blood drug concentration ranges (low, medium, and high). With the caveat that concentration ranges are sufficiently separated, this design should enhance the ability to discover important concentration response relationships. FK-506, a potent and promising immunosuppressive agent for prevention and treatment of graft rejection, has shown significant clinical activity in some immune-mediated disorders. To implement the RCCCT design, a novel FK-506 intelligent dosing system (IDS) was used to guide all doses to prospectively achieve the target concentration range specified in the study protocol. Patients enrolled in these trials suffered from a variety of autoimmune disorders, including multiple sclerosis, primary biliary cirrhosis, psoriasis, autoimmune chronic active hepatitis, and nephrotic syndrome. We observed excellent predictive performance of the IDS for all patients. The accuracy (mean prediction error) of the IDS was −0.022 ng/ml and the precision (standard deviation of the prediction error) was 0.119 ng/ml. Thus, the IDS is both accurate and reproducible for autoimmune patients. We conclude that the RCCCT design, guided by an accurate and precise IDS, is an informative and cost-effective approach for evaluation of efficacy and safety of effective but highly toxic agents. © 1993 Raven Press, Ltd., New York

Electron surface layer at the interface of a plasma and a dielectric wall

We study the potential and the charge distribution across the interface of a plasma and a dielectric wall. For this purpose, the charge bound to the wall is modelled as a quasi-stationary electron surface layer which satisfies Poisson's equation and minimizes the grand canonical potential of the wall-thermalized excess electrons constituting the wall charge. Based on an effective model for a graded interface taking into account the image potential and the offset of the conduction band to the potential just outside the dielectric, we specifically calculate the potential and the electron distribution for magnesium oxide, silicon dioxide and sapphire surfaces in contact with a helium discharge. Depending on the electron affinity of the surface, we find two vastly different behaviors. For negative electron affinity, electrons do not penetrate into the wall and an external surface charge is formed in the image potential, while for positive electron affinity, electrons penetrate into the wall and a space charge layer develops in the interior of the dielectric. We also investigate how the electron surface layer merges with the bulk of the dielectric.Comment: 15 pages, 9 figures, accepted versio

A Conjugate Study of Mean Winds and Planetary Waves Employing Enhanced Meteor Radars at Rio Grande, Argentina (53.8degS) and Juliusruh, Germany (54.6degN)

Two meteor radars with enhanced power and sensitivity and located at closely conjugate latitudes (54.6degN and 53.8degS) are employed for inter-hemispheric comparisons of mean winds and planetary wave structures. Our study uses data from June 2008 through May 2010 during which both radars provided nearly continuous wind measurements from approx.80 to 100 km. Monthly mean winds at 53.8degS exhibit a somewhat stronger westward mean zonal jet in spring and early summer at lower altitudes and no westward monthly mean winds at higher altitudes. In contrast, westward mean winds of approx.5-10 m/s at 54.6degN extend to above 96 km during late winter and early spring each year. Equatorward monthly mean winds extend approximately from spring to fall equinox at both latitudes, with amplitudes of approx.5-10 m/s and more rapid decreases in amplitude at 54.6degN at higher altitudes. Meridional mean winds are more variable at both latitudes during fall and winter, with both poleward and equatorward monthly means indicating longer-period variability. Planetary waves seen in the 2-day mean data are episodic and variable at both sites, exhibit dominant periodicities of approx.8-10 and 16-20 days and are more confined to late fall and winter at 54.6degN. At both latitudes, planetary waves in the two period bands coincide closely in time and exhibit similar horizontal velocity covariances that are positive (negative) at 54.6degN (53.8degS) during peak planetary wave responses

APPARATUS FOR THE STUDY OF FISSION-GAS RELEASE FROM NEUTRON-ACTIVATED FUELED GRAPHITE

A simple laboratory apparatus for the study of fissiongas release from neutron-activated fueled graphite was developed. Xenon-133 released from a heated specimen is carried in a helium sweep gas to a charcoal trap, where the accumulated activity is monitored continuously by a scintillation detector, ratemeter, and pen recorder. The maximum specimen temperature (2500 deg F) is achieved in 10 min with an induction heater. All instrumentation is commercially available. Data for several neutron-activated fueled-graphite specimens heated in the range from 800 to 2500 deg F are presented to illustrate the typical results obtained with the apparatus. (auth

Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling

BACKGROUND: The physiological regulation of G protein-coupled receptors, through desensitization and internalization, modulates the length of the receptor signal and may influence the development of tolerance and dependence in response to chronic drug treatment. To explore the importance of receptor regulation, we engineered a series of G(i)-coupled receptors that differ in signal length, degree of agonist-induced internalization, and ability to induce adenylyl cyclase superactivation. All of these receptors, based on the kappa opioid receptor, were modified to be receptors activated solely by synthetic ligands (RASSLs). This modification allows us to compare receptors that have the same ligands and effectors, but differ only in desensitization and internalization. RESULTS: Removal of phosphorylation sites in the C-terminus of the RASSL resulted in a mutant that was resistant to internalization and less prone to desensitization. Replacement of the C-terminus of the RASSL with the corresponding portion of the mu opioid receptor eliminated the induction of AC superactivation, without disrupting agonist-induced desensitization or internalization. Surprisingly, removal of phosphorylation sites from this chimera resulted in a receptor that is constitutively internalized, even in the absence of agonist. However, the receptor still signals and desensitizes in response to agonist, indicating normal G-protein coupling and partial membrane expression. CONCLUSIONS: These studies reveal that internalization, desensitization and adenylyl cyclase superactivation, all processes that decrease chronic G(i)-receptor signals, are independently regulated. Furthermore, specific mutations can radically alter superactivation or internalization without affecting the efficacy of acute G(i )signaling. These mutant RASSLs will be useful for further elucidating the temporal dynamics of the signaling of G protein-coupled receptors in vitro and in vivo

Data reduction and analysis of graphite fiber release experiments

The burn and burn/explode effects on aircraft structures were examined in a series of fifteen outdoor tests conducted to verify the results obtained in previous burn and explode tests of carbon/graphite composite samples conducted in a closed chamber, and to simulate aircraft accident scenarios in which carbon/graphite fibers would be released. The primary effects that were to be investigaged in these tests were the amount and size distribution of the conductive fibers released from the composite structures, and how these various sizes of fibers transported downwind. The structures included plates, barrels, aircraft spoilers and a cockpit. The heat sources included a propane gas burner and 20 ft by 20 ft and 40 ft by 60 ft JP-5 pool fires. The larger pool fire was selected to simulate an aircraft accident incident. The passive instrumentation included sticky paper and sticky bridal veil over an area 6000 ft downwind and 3000 ft crosswind. The active instrumentation included instrumented meteorological towers, movies, infrared imaging cameras, LADAR, high voltage ball gages, light emitting diode gages, microwave gages and flame velocimeter

Feasibility study of positive gauging systems. Phase 2 - Design and analysis

Resonant infrasonic gauging system investigated for Apollo project propulsion syste

Interplay Between Chaotic and Regular Motion in a Time-Dependent Barred Galaxy Model

We study the distinction and quantification of chaotic and regular motion in a time-dependent Hamiltonian barred galaxy model. Recently, a strong correlation was found between the strength of the bar and the presence of chaotic motion in this system, as models with relatively strong bars were shown to exhibit stronger chaotic behavior compared to those having a weaker bar component. Here, we attempt to further explore this connection by studying the interplay between chaotic and regular behavior of star orbits when the parameters of the model evolve in time. This happens for example when one introduces linear time dependence in the mass parameters of the model to mimic, in some general sense, the effect of self-consistent interactions of the actual N-body problem. We thus observe, in this simple time-dependent model also, that the increase of the bar's mass leads to an increase of the system's chaoticity. We propose a new way of using the Generalized Alignment Index (GALI) method as a reliable criterion to estimate the relative fraction of chaotic vs. regular orbits in such time-dependent potentials, which proves to be much more efficient than the computation of Lyapunov exponents. In particular, GALI is able to capture subtle changes in the nature of an orbit (or ensemble of orbits) even for relatively small time intervals, which makes it ideal for detecting dynamical transitions in time-dependent systems.Comment: 21 pages, 9 figures (minor typos fixed) to appear in J. Phys. A: Math. Theo