A Deep Chandra Observation of the Giant HII Region N11 I. X-ray Sources in the Field

A very sensitive X-ray investigation of the giant HII region N11 in the LMC was performed using the Chandra X-ray Observatory. The 300ks observation reveals X-ray sources with luminosities down to 10^32 erg/s, increasing by more than a factor of 5 the number of known point sources in the field. Amongst these detections are 13 massive stars (3 compact groups of massive stars, 9 O-stars and one early B-star) with log(Lx/Lbol)~-6.5 to -7, which may suggest that they are highly magnetic or colliding wind systems. On the other hand, the stacked signal for regions corresponding to undetected O-stars yields log(Lx/Lbol)~-7.3, i.e., an emission level comparable to similar Galactic stars despite the lower metallicity. Other point sources coincide with 11 foreground stars, 6 late-B/A stars in N11, and many background objects. This observation also uncovers the extent and detailed spatial properties of the soft, diffuse emission regions but the presence of some hotter plasma in their spectra suggests contamination by the unresolved stellar population.Comment: file including online material, accepted for publication by ApJ

Research on 3D chatter stability of blade by high-speed turn-milling

High speed turn-milling is regarded as the milling of a curved surface while rotating the workpiece around its centre point, which combines effectively the advantages of both turning and milling, wherein allows for good metal removal with the difficult-to-cut thin-walled workpieces in aviation. The objective of the present work is to study chatter stability of thin-walled blade by high-speed turn-milling in cutting condition. The dynamic model and the stability critical condition determined by the relative dynamic characteristics between cutter subsystem and blade subsystem are put forward. Aiming at the small-stiffness frequency response characteristics of thin walled structures, the stability critical domain is predicted based on the high-order dynamic behavior of the multi-DOF system. It can be shown that the chatter condition in turn-milling is closely related to both cutter speed and depth of cut, besides cutter geometry, engagement conditions, frequency response function, material property of workpiece and so on. Based on chatter stability simulation model to access 3D chatter stability lobes of high-speed turn-milling machining blades. This conclusion provides a theoretical foundation and reference for the orthogonal turn-milling mechanism research

Research on Cutting Force of Turn-Milling Based on Thin-Walled Blade

Turn-milling is regarded as the milling of a curved surface while rotating the workpiece around its center point, which combines effectively the advantages of both turning and milling, wherein it allows for good metal removal with the difficult-to-cut thin-walled workpieces in aviation. The objective of the present work is to study cutting force by turn-milling in cutting condition. Aiming at the deformation properties of thin-walled blade, the predicted models of rigid cutting force and flexible cutting force with ball cutter are provided, respectively, in turn-milling process. The deformation values of blade and cutter are calculated, respectively, based on the engaged trajectory by using the iterative algorithm. The rigid and flexible cutting forces are compared and the influence degrees of cutting parameters on cutting forces are analyzed. These conclusions provide theoretical foundation and reference for turn-milling mechanism research

Design and compressive behavior of controllable irregular porous scaffolds: based on Veronoi-tessellation and for additive manufacturing

Adjustment of the mechanical properties (apparent elastic modulus and compressive strength) in porous scaffolds is important for artificial implants and bone tissue engineering. In this study, a top-down design method based on Voronoi-Tessellation was proposed. This method was successful in obtaining the porous structures with specified and functionally graded porosity. The porous specimens were prepared by selective laser melting technology. Quasi-static compressive tests were conducted as well. The experiment results revealed that the mechanical properties were affected by both porosity and irregularity. The irregularity coefficient proposed in this study can achieve good accommodation and balance of “irregularity” and “controllability”. The method proposed in this study provides an efficient approach for the bionic design and topological optimization of scaffolds

Modulation of Actin Filament Dynamics by Inward Rectifying of Potassium Channel Kir2.1

Apart from its ion channel properties, the Kir2.1 channel has been found in tumors and cancer cells to facilitate cancer cell motility. It is assumed that Kir2.1 might be associated with cell actin filament dynamics. With the help of structured illumination microscopy (SIM), we show that Kir2.1 overexpression promotes actin filament dynamics, cell invasion, and adhesion. Mutated Kir2.1 channels, with impaired membrane expression, present much weaker actin regulatory effects, which indicates that precise Kir2.1 membrane localization is key to its actin filament remolding effect. It is found that Kir2.1 membrane expression and anchoring are associated with PIP2 affinity, and PIP2 depletion inhibits actin filament dynamics. We also report that membrane-expressed Kir2.1 regulates redistribution and phosphorylation of FLNA (filamin A), which may be the mechanism underlying Kir2.1 and actin filament dynamics. In conclusion, Kir2.1 membrane localization regulates cell actin filaments, and not the ion channel properties. These data indicate that Kir2.1 may have additional cellular functions distinct from the regulation of excitability, which provides new insight into the study of channel proteins

Properties of jet-plated Ni coating on Ti alloy (Ti6Al4V) with laser cleaning pretreatment

The surface mechanical properties of the Selective Laser Melting (SLM) formed Ti6Al4V samples were improved by adopting a novel laser cleaning pretreatment process combined with a jet electrodeposition process. This paper aimed to investigate the effects of different laser powers on the morphologies and adhesions of the nickel coatings. The advantages of the laser cleaning process are no grinding, no contact, high efficiency and environmental protection. The morphologies, adhesion, wear resistance, and hardness of the coatings were characterized. The results indicate that when the laser energy density reached 20% (4 J/cm2), the contaminations on the substrate and the oxide layer were removed and the crystalline grain of the coating was 15.3 nm. The shallow pits generated by laser burning increased the adhesion of the coatings. In addition, when the laser energy density increased to 6 J/cm2, a yellow oxide layer was produced on the surface of the cleaned titanium alloy. Moreover, the wear resistance of the titanium alloy after the nickel plating was improved. The wear volume was only 0.046 mm3, and the hardness increased to 1967.6 N/mm2

Effects of Astragaloside IV on heart failure in rats

<p>Abstract</p> <p>Background</p> <p>Astragaloside IV (ASI) in <it>Radix Astragali </it>is believed to be the active component in treating heart failure. The present study aims to examine the effects of ASI on cardiovascular parameters in long-term heart failure in rats.</p> <p>Methods</p> <p>Using echocardiographic and haemodynamic measurements, we studied the effects of ASI on congestive heart failure (CHF) induced by ligation of the left coronary artery in rats.</p> <p>Results</p> <p>ASI (0.1, 0.3 and 1.0 mg/kg/day) attenuated the decline of fractional shortening (FS). The peak derivatives of the left ventricle (LV) pressure (dp/dt) in ASI-treated groups significantly increased. Both LV internal diameters in diastole (LVIDd) and in systole (LVIDs) decreased significantly after ASI treatment (0.3 and 1.0 mg/kg/day). ASI (1.0 mg/kg/day) attenuated the decrease of LV systolic pressure (LVSP). ASI treatment inhibited compensatory hypertrophy of myocardial cells and lowered the number of apoptotic myocytes.</p> <p>Conclusion</p> <p>ASI improved cardiac functions as measured by cardiovascular parameters.</p

Distortion of thin-walled structure fabricated by selective laser melting based on assumption of constraining force-induced distortion

Metal additive manufacturing has shown great potential in aerospace, medical, and automobile industries; however, distortion of metal part has been an obstacle in widespread application of metal additive manufacturing. The mechanism of thin-walled structure distortion remains unrevealed. In this study, the origin of distortion of thin-walled structure was discussed, based on the previously proposed assumption of constraining force-induced distortion. The relation between the microstructure and macro-distortion has been linked via the constraining force. The influence of scan directions and structure sizes on the distortion was also studied, and the approaches to decrease the thin-walled structure were discussed. Use of the alternant scan strategy has been validated as an effective approach if the structure sizes cannot be adjusted