Global Journalist: Reconstruction after the Iraq War

This is a Global Journalist conversation from April 17, 2003 between Stuart Loory and journalists on what to expect for the reconstruction process following the end of the war in Iraq. They examine past reconstruction in Afghanistan and Bosnia and determine what should and should not be repeated in Iraq. Host: Stuart Loory. Guests: John Lichfield (Paris), Senad Slatina (Bosnia), Razia Sultana (Pakistan). Producers: Sara Andrea Fajardo, Augustine Pang. Director: Mary Furness

Meta-analyses of Phase 3 randomised controlled trials of third generation aromatase inhibitors versus tamoxifen as first-line endocrine therapy in postmenopausal women with hormone receptor-positive advanced breast cancer

Background Four randomised controlled trials (RCTs) in postmenopausal women with advanced breast cancer (ABC) comparing aromatase inhibitors (AIs) versus the selective estrogen receptor modulator tamoxifen, each individually reported significantly longer progression free survival (PFS) but none showed a significant difference in overall survival (OS). In these trials between 6.8%–55% of tumours were hormone receptor (HR) status unknown or negative. This meta-analysis restricted the comparison to HR-positive (HR+) tumours. MethodsAnonymised individual patient data were obtained from three RCTs, EORTC (exemestane versus tamoxifen), Study 0027 and Study 0030 (both anastrozole versus tamoxifen). For the remaining RCT (Femara Study PO25; letrozole versus tamoxifen), odds ratio (OR) or hazard ratio (HzR), with confidence intervals were obtained from the clinical study report, for patients with HR+ tumours, in addition to published data. In total, data were obtained from 2296 patients; 1560 (68%) had HR+ ABC. FindingsThe OR for clinical benefit rate was 1·56, in favour of AIs (p[less than] 0·001). The duration of clinical benefit was not significantly increased by AIs (hazard ratio [HzR] 0·88; p=0·08). For PFS the HzR (0·82) was in favour of AIs (p=0·007). However, for OS the HzR (1·05) was not significantly different between AIs and tamoxifen (p=0·42).InterpretationAlthough third generation AIs put significantly more patients into ‘clinical benefit’, their tumours were not controlled for significantly longer. Overall, while this resulted in a significantly greater PFS in favour of the AIs, this did not translate into improvement in OS

Health-related quality of life from the FALCON phase III randomised trial of fulvestrant 500 mg versus anastrozole for hormone receptor-positive advanced breast cancer

Background The phase III randomised FALCON trial (NCT01602380) demonstrated improved progression-free survival with fulvestrant 500 mg versus anastrozole 1 mg in endocrine therapy-naïve postmenopausal women with hormone receptor-positive (HR+) locally advanced or metastatic breast cancer (LA/MBC). Furthermore, overall health-related quality of life (HRQoL) was maintained and comparable for fulvestrant and anastrozole. Here, we present additional analyses of patient-reported HRQoL outcomes from FALCON. Methods Women with endocrine therapy-naïve HR+ LA/MBC were randomised 1:1 to fulvestrant (days 0, 14, 28, then every 28 d) or anastrozole (daily) until disease progression or discontinuation. HRQoL was assessed by FACT-B questionnaire (TOI and FACT-B total score) at randomisation and every 12 weeks during treatment. HRQoL data post-treatment (with or without progression) were also collected. Results In total, 462 patients were randomised (fulvestrant, n = 230; anastrozole, n = 232). Compliance to FACT-B overall ranged from 60.0 to 97.4%. Mean change from baseline in TOI and FACT-B total score remained broadly stable (approximately ± 3 points to week 132) and was similar between arms during treatment. HRQoL was also maintained in FACT-B subscales. Approximately one-third of patients had improved TOI (≥+6 points) and FACT-B (≥+8 points) total scores from baseline up to week 120 and 132, respectively, of treatment with fulvestrant (ranges 26.4–45.0% and 22.4–35.8%, respectively) and anastrozole (ranges 18.6–32.9%, and 22.7–37.9%, respectively). Conclusions Mean change from baseline in TOI and FACT-B total score was maintained for fulvestrant and anastrozole; similar proportions of patients in both arms had improved TOI and FACT-B total scores

Constructing the eastern european other: The horsemeat scandal and the migrant other

The Horsemeat scandal in the UK in 2013 ignited a furore about consumer deception and the bodily transgression of consuming something so alien to the British psyche. The imagination of the horse as a noble and mythic figure in British history and sociological imagination was invoked to construct the consumption of horsemeat as a social taboo and an immoral proposition in the British media debates. This paper traces the horsemeat scandal and its media framing in the UK. Much of the aversion to horsemeat was intertextually bound with discourses of immigration, the expansion of the EU and the threat in tandem to the UK. Food as a social and cultural artefact laden with symbolic meaning and national pride became a platform to construct the ‘Other’ – in this case the Eastern European Other. The media debates on the horsemeat scandal interwove the opening up of the EU and particularly UK to the influx of Eastern European migration. The horsemeat controversy in implicating the Eastern Europeans for the contamination of the supply chain became a means to not just construct the ‘Other’ but also to entwine contemporary policy debates about immigration. This temporal framing of contemporary debates enables a nation to renew and contemporise its notions of ‘otherness’ while sustaining an historic social imaginary of itself

Johannis VVallisi, SS. Th.D. geometriae professoris Saviliani in celeberrimãa Academia Oxoniensi, operum mathematicorum pars prima [electronic resource] : qua continentur, oratio inauguralis. Mathesis universalis, sive, Arithmeticum tum speciosam complectens. Adversis Meibomii, de proportionibus dialogum, tractatis elencticus.

"Johannis VVallis, Geometriae Professoris Saviliani, Oratio inauguralis" has separate dated title page; it is unpaginated. "Johannis VVallisi, S.S. Th.D. Geometriae Professoris Saviliani in celeberrimãa Academia Oxoniensi; Mathesis universalis" and "Johannis Wallisi S.S. Th.D. Geometriae Professoris Saviliani, in celeberrima Academia Oxoniensi; Adversus Marci Meibomii, de proportionibus dialogum, tractatus elenctius" each have separate dated title page and pagination; register is continuous. "De proportionibus, dialogi; a Marco Meibomio conscripti; refutatio" (caption title) has separate pagination and register.Text continuous despite pagination.Wing, D.G. Short-title catalogue of books printed in England, Scotland, Ireland, Wales, and British America, and of English books printed in other countries, 1641-1700 (2nd ed. 1994),English short title catalogue,Includes a chapter on logarithms and a passage about chess in Persian and LatinIncludes errata.Reproduction of original in: Henry E. Huntington Library and Art Gallery.Electronic reproduction

The common-prayer-book [electronic resource] : the best companion in the house and closet as well as in the temple, or a collection of prayers out of the liturgie of the Church of England, most needul both for the whole family together, and for every single person apart by himself : with a particular office for the sacrament.

Compiled by William Howell.Wing, D.G. Short-title catalogue of books printed in England, Scotland, Ireland, Wales, and British America, and of English books printed in other countries, 1641-1700 (2nd ed. 1994),English short title catalogue,Reproduction of original in: York Minster Library.Electronic reproduction