The accuracy of frozen section analysis in ultrasound- guided core needle biopsy of breast lesions

<p>Abstract</p> <p>Background</p> <p>Limited data are available to evaluate the accuracy of frozen section analysis and ultrasound- guided core needle biopsy of the breast.</p> <p>Methods</p> <p>In a retrospective analysis data of 120 consecutive handheldultrasound- guided 14- gauge automated core needle biopsies (CNB) in 109 consecutive patients with breast lesions between 2006 and 2007 were evaluated.</p> <p>Results</p> <p>In our outpatient clinic120 CNB were performed. In 59/120 (49.2%) cases we compared histological diagnosis on frozen sections with those on paraffin sections of CNB and finally with the result of open biopsy. Of the cases 42/59 (71.2%) were proved to be malignant and 17/59 (28.8%) to be benign in the definitive histology. 2/59 (3.3%) biopsies had a false negative frozen section result. No false positive results of the intraoperative frozen section analysis were obtained, resulting in a sensitivity, specificity and positive predicting value (PPV) and negative predicting value (NPV) of 95%, 100%, 100% and 90%, respectively. Histological and morphobiological parameters did not show up relevance for correct frozen section analysis. In cases of malignancy time between diagnosis and definitive treatment could not be reduced due to frozen section analysis.</p> <p>Conclusion</p> <p>The frozen section analysis of suspect breast lesions performed by CNB displays good sensitivity/specificity characteristics. Immediate investigations of CNB is an accurate diagnostic tool and an important step in reducing psychological strain by minimizing the period of uncertainty in patients with breast tumor.</p

Safety, tolerability and efficacy of intradermal rabies immunization with DebioJect™.

In a single-center study, 66 healthy volunteers aged between 18 and 50years were randomized to be immunized against rabies with three different injection routes: intradermal with DebioJect™ (IDJ), standard intradermal with classical needle (IDS), also called Mantoux method, and intramuscular with classical needle (IM). "Vaccin rabique Pasteur®" and saline solution (NaCl 0.9%) were administered at D0, D7 and D28. Antigen doses for both intradermal routes were 1/5 of the dose for IM. Tolerability, safety and induced immunogenicity of IDJ were compared to IDS and IM routes. Pain was evaluated at needle insertion and at product injection for all vaccination visits. Solicited Adverse Event (SolAE) and local reactogenicity symptoms including pain, redness and pruritus were recorded daily following each vaccination visit. Adverse events (AE) were recorded over the whole duration of the study. Humoral immune response was measured by assessing the rabies virus neutralizing antibody (VNA) titers using Rapid Fluorescent Focus Inhibition Test (RFFIT). Results demonstrated that the DebioJect™ is a safe, reliable and efficient device. Significant decreases of pain at needle insertion and at vaccine injection were reported with IDJ compared to IDS and IM. All local reactogenicity symptoms (pain, redness and pruritus) after injection with either vaccine or saline solution, were similar for IDJ and IDS, except that IDJ injection induced more redness 30min after saline solution. No systemic SolAE was deemed related to DebioJect™ and classical needles. No AE was deemed related to DebioJect™. No Serious Adverse Event (SAE) was reported during the study. At the end of the study all participants were considered immunized against rabies and no significant difference in humoral response was observed between the 3 studied routes

An examination of the effects of self-regulatory focus on the perception of the media richness: the case of email

Communication is a key element in organizations’ business success. The media richness theory and the channel expansion theory are two of the most influential theories regarding the selection and use of communication media in organizations; however, literature has focused little on the effects of self-regulation by managers and employees in these theories. To analyze these topics, this study develops an empirical investigation by gathering data from 600 managers and employees using a questionnaire. The results suggest that the perception of media richness is positively affected when the individual shows a promotion focus or strategy.Peer ReviewedPostprint (author’s final draft

Repulsive Core of NN S-Wave Scattering in a Quark Model with a Condensed Vacuum

We work in a chiral invariant quark model, with a condensed vacuum, characterized by only one parameter. Bound state equations for the nucleon and Delta are solved in order to obtain an updated value of their radii and masses. Nucleon-nucleon S-Wave scattering is studied in the RGM framework both for isospin T=1 and T=0. The phase shifts are calculated and an equivalent local potential, which is consistent with K-N scattering, is derived. The result is a reasonable microscopic short range repulsion in the nucleon-nucleon interaction.Comment: 23 pages in latex revtex, 4 Postscript figure

Ultrasound-guided core-needle biopsy of breast lesions

Ultrasound-guided CNB has proven to be a reliable technique for performing a biopsy for breast lesions that can be clearly seen on ultrasoun

On the Dynamical Overstability of Radiative Blast Waves: The Atomic Physics of Shock Stability

Atomic physics calculations of radiative cooling are used to calculate criteria for the overstability of radiating shocks. Our calculations explain the measurement of shock overstability by Grun et al. and explain why the overstability was not observed in other experiments. The methodology described here can be especially useful in astrophysical situations where the relevant properties leading to an overstability can be measured spectroscopically, but the effective adiabatic index is harder to determine.Comment: 11 pages including 3 figures, accepted for publication in Physical Review Letter

Ground state hyperfine structures of 43K and 44K measured by atomic beam magnetic resonance coupled with laser optical pumping

The ground state hyperfine structures of 43 K and 44K have been measured by an atomic beam magnetic resonance method in which the atoms are spin-polarized by laser optical pumping. The spectroscopic results are : Δv43( 2S1/2) = 192.648 4 (30) MHz and Δν44( 2S1/2) = - 946.718 (3) MHz. The sensitivity of our method is compared to the one achieved in classical ABMR apparatus

Exactly Solvable Models: The Road Towards a Rigorous Treatment of Phase Transitions in Finite Systems

We discuss exact analytical solutions of a variety of statistical models recently obtained for finite systems by a novel powerful mathematical method, the Laplace-Fourier transform. Among them are a constrained version of the statistical multifragmentation model, the Gas of Bags Model and the Hills and Dales Model of surface partition. Thus, the Laplace-Fourier transform allows one to study the nuclear matter equation of state, the equation of state of hadronic and quark gluon matter and surface partitions on the same footing. A complete analysis of the isobaric partition singularities of these models is done for finite systems. The developed formalism allows us, for the first time, to exactly define the finite volume analogs of gaseous, liquid and mixed phases of these models from the first principles of statistical mechanics and demonstrate the pitfalls of earlier works. The found solutions may be used for building up a new theoretical apparatus to rigorously study phase transitions in finite systems. The strategic directions of future research opened by these exact results are also discussed.Comment: Contribution to the ``World Consensus Initiative III, Texas A & M University, College Station, Texas, USA, February 11-17, 2005, 21