Top of the tops: Combining searches for Dark Matter with top quarks at √s = 13 TeV with the ATLAS detector

Trotz der zahlreichen astrophysikalisch und kosmologisch überzeugenden Beweise für Dunkle Materie bleibt ihre wahre Natur unbekannt. Eine Motivation für die Suche nach Dunkler Materie am Large Hadron Collider (LHC) und insbesondere mit dem ATLAS-Experiment ist die besonders vielversprechende Möglichkeit, dass Wechselwirkungen zwischen gewöhnlicher Materie und Dunkler Materie durch neue Spin-0-Teilchen vermittelt werden. Solche Teilchen würden das Standardmodell um einen potentiellen Dunklen Sektor erweitern, zu dem die Teilchen der Dunklen Materie gehören. ähnlich wie das Higgs-Boson interagieren diese neuen Mediatoren am stärksten mit den schwersten Teilchen über Kopplungen vom Yukawa-Typ, wodurch sie empfänglicher für die damit verbundene Produktion durch Quarks mit schwerem Flavour werden. Diese Dissertation präsentiert die Ergebnisse der statistischen Kombination von zwei Suchen, die auf die mit Dunkler Materie verbundene Produktion von einem Top-Quark-Paar oder einem einzelnen Top-Quark, jeweils zwei geladenen Leptonen im Endzustand, abzielen. Diese beiden Kanäle weisen komplementäre Eigenschaften auf, und eine Kombination kann die Empfindlichkeit gegenüber Dunkle-Materie-Signalen erheblich verbessern. Diese Kombination wird unter Verwendung von 139 fb-1 pp-Kollisionsdaten durchgeführt, die bei einer Schwerpunktsenergie von 13 TeV erzeugt und vom ATLAS-Detektor am LHC aufgezeichnet wurden. Die Ergebnisse der Kombination werden in Bezug auf vereinfachte Modelle für Dunklen Materie mit einem skalaren oder pseudoskalaren Spin-0-Mediator interpretiert. Die statistische Kombination weitet die bei einem Konfidenzniveau von 95% ausgeschlossenen Massen auf bis zu 350 GeV sowohl für skalare als auch für pseudoskalare Mediatoren aus. Die beobachteten Ausschlu{\ss}grenzen des Wirkungsquerschnitts werden für den ska\-laren (pseudoskalaren) Mediator um 20%(30%) gegenüber dem Besten des einzelnen Kanals verbessert.Despite the multiple astrophysical and cosmological compelling evidences for Dark Matter, its true nature remains unknown. A motivation to dark matter searches at the Large Hadron Collider (LHC), and in particular in the ATLAS experiment, is the especially promising possibility that interactions between ordinary matter and dark matter are mediated by new spin-0 particles. Such particles would extend the Standard Model with a potential dark sector, to which dark matter particles belong. Similarly to the Higgs boson, these new mediators interact strongest with the heaviest particles via Yukawa-type couplings, making them more prone to associated production with heavy-flavour quarks. This thesis presents the results of the statistical combination of two searches targeting dark matter associated production with a top quark pair and a single top quark, targeting two charged leptons in the final state. These two channels present in fact complementary properties and a combination could enhance significantly the sensitivity to dark matter signals. This combination is carried out using 139 fb-1 of pp collision data produced at centre-of-mass of 13 TeV recorded by the ATLAS detector at the LHC. The results of the combination are interpreted in terms of simplified dark matter models with a spin-0 scalar or pseudoscalar mediator particle. The statistical combination extends the exclusion at 95 % Confidence Level (CL) of masses up to 350 GeV for both scalar and pseudoscalar mediators. The observed upper limits on the cross-section are improved up by 20 %(30 %) for scalar(pseudoscalar) mediator with respect to the best of the individual channel

Disease-Modifying Therapies and Coronavirus Disease 2019 Severity in Multiple Sclerosis

Objective: This study was undertaken to assess the impact of immunosuppressive and immunomodulatory therapies on the severity of coronavirus disease 2019 (COVID-19) in people with multiple sclerosis (PwMS). Methods: We retrospectively collected data of PwMS with suspected or confirmed COVID-19. All the patients had complete follow-up to death or recovery. Severe COVID-19 was defined by a 3-level variable: mild disease not requiring hospitalization versus pneumonia or hospitalization versus intensive care unit (ICU) admission or death. We evaluated baseline characteristics and MS therapies associated with severe COVID-19 by multivariate and propensity score (PS)-weighted ordinal logistic models. Sensitivity analyses were run to confirm the results. Results: Of 844 PwMS with suspected (n = 565) or confirmed (n = 279) COVID-19, 13 (1.54%) died; 11 of them were in a progressive MS phase, and 8 were without any therapy. Thirty-eight (4.5%) were admitted to an ICU; 99 (11.7%) had radiologically documented pneumonia; 96 (11.4%) were hospitalized. After adjusting for region, age, sex, progressive MS course, Expanded Disability Status Scale, disease duration, body mass index, comorbidities, and recent methylprednisolone use, therapy with an anti-CD20 agent (ocrelizumab or rituximab) was significantly associated (odds ratio [OR] = 2.37, 95% confidence interval [CI] = 1.18-4.74, p = 0.015) with increased risk of severe COVID-19. Recent use (<1 month) of methylprednisolone was also associated with a worse outcome (OR = 5.24, 95% CI = 2.20-12.53, p = 0.001). Results were confirmed by the PS-weighted analysis and by all the sensitivity analyses. Interpretation: This study showed an acceptable level of safety of therapies with a broad array of mechanisms of action. However, some specific elements of risk emerged. These will need to be considered while the COVID-19 pandemic persists

The ABC130 barrel module prototyping programme for the ATLAS strip tracker

For the Phase-II Upgrade of the ATLAS Detector, its Inner Detector, consisting of silicon pixel, silicon strip and transition radiation sub-detectors, will be replaced with an all new 100 % silicon tracker, composed of a pixel tracker at inner radii and a strip tracker at outer radii. The future ATLAS strip tracker will include 11,000 silicon sensor modules in the central region (barrel) and 7,000 modules in the forward region (end-caps), which are foreseen to be constructed over a period of 3.5 years. The construction of each module consists of a series of assembly and quality control steps, which were engineered to be identical for all production sites. In order to develop the tooling and procedures for assembly and testing of these modules, two series of major prototyping programs were conducted: an early program using readout chips designed using a 250 nm fabrication process (ABCN-25) and a subsequent program using a follow-up chip set made using 130 nm processing (ABC130 and HCC130 chips). This second generation of readout chips was used for an extensive prototyping program that produced around 100 barrel-type modules and contributed significantly to the development of the final module layout. This paper gives an overview of the components used in ABC130 barrel modules, their assembly procedure and findings resulting from their tests.Comment: 82 pages, 66 figure

COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context

Background and objectives: It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim of this study is to compare COVID-19-related outcomes collected in an Italian cohort of patients with MS with the outcomes expected in the age- and sex-matched Italian population. Methods: Hospitalization, intensive care unit (ICU) admission, and death after COVID-19 diagnosis of 1,362 patients with MS were compared with the age- and sex-matched Italian population in a retrospective observational case-cohort study with population-based control. The observed vs the expected events were compared in the whole MS cohort and in different subgroups (higher risk: Expanded Disability Status Scale [EDSS] score > 3 or at least 1 comorbidity, lower risk: EDSS score ≤ 3 and no comorbidities) by the χ2 test, and the risk excess was quantified by risk ratios (RRs). Results: The risk of severe events was about twice the risk in the age- and sex-matched Italian population: RR = 2.12 for hospitalization (p < 0.001), RR = 2.19 for ICU admission (p < 0.001), and RR = 2.43 for death (p < 0.001). The excess of risk was confined to the higher-risk group (n = 553). In lower-risk patients (n = 809), the rate of events was close to that of the Italian age- and sex-matched population (RR = 1.12 for hospitalization, RR = 1.52 for ICU admission, and RR = 1.19 for death). In the lower-risk group, an increased hospitalization risk was detected in patients on anti-CD20 (RR = 3.03, p = 0.005), whereas a decrease was detected in patients on interferon (0 observed vs 4 expected events, p = 0.04). Discussion: Overall, the MS cohort had a risk of severe events that is twice the risk than the age- and sex-matched Italian population. This excess of risk is mainly explained by the EDSS score and comorbidities, whereas a residual increase of hospitalization risk was observed in patients on anti-CD20 therapies and a decrease in people on interferon

DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon

Constraints on spin-0 dark matter mediators and invisible Higgs decays using ATLAS 13 TeV pppp collision data with two top quarks and missing energy in the final state

The statistical combination of searches targeting final states with two top quarks and invisible particles and characterised by the presence of zero, one or two leptons, at least one jet originating from a b-quark and missing transverse momentum is presented. The analyses are performed with the ATLAS detector using 139 fb$^{-1}$ of $pp$ collisions at a centre-of-mass energy of 13 TeV at the LHC and search for beyond the standard model phenomena consistent with the production of dark matter particles at colliders. The results are interpreted in terms of simplified dark matter models with a spin-0 scalar or pseudoscalar mediator particle. In addition, the results are interpreted in terms of upper limits on the Higgs boson invisible branching ratio, where the Higgs is produced according to the Standard Model in association with a pair of top quarks

Studies on the W+bbˉW+b\bar{b} production simulation at the ATLAS experiment

The associate production of a vector boson (decaying into a leptonic final state) and HF-quarks is particularly interesting both as a SM process and as a relevant source of background to several LHC Run II searches. In the framework of the search for the Higgs boson decaying to a b-quark pair and produced in association with a W vector boson, we studied the kinematic and topological properties of simulated events, before proceeding with a systematic comparison of two specific Monte-Carlo generators for $W+b\bar{b}$ production, Alpgen and Sherpa

Status of LLP and dark sector searches with the ATLAS and CMS experiments

In this talk, lastest results in LLP and dark sector searches from the ATLAS and CMS experiments using full Run 2 dataset are presented