Critical barriers and countermeasures to urban regeneration from the stakeholder perspective: a literature review

Urban renewal involves a wide range of stakeholders with diverse expectations and interests. Conflicts in urban renewal projects arise from intricate relationships among multiple stakeholders, hindering the urban renewal process. With a large amount of current literature examining the barriers, difficulties, and solutions in urban regeneration, a critical review is required to holistically summarize these main concerns and challenges from the stakeholder perspective. Based on 347 journal papers collected from the Web of Science core database, this study investigates the development, trajectory, and tendency of prior studies through a bibliometric analysis. Then, a critical review is documented with eight critical barriers in the economic and social aspects from the stakeholder perspective. To address these issues, this study proposes a strategic framework for value creation, collaborative governance, and benefit sharing. Accordingly, future research agendas are also presented. This study could provide researchers with a systematic understanding of the critical barriers and potential strategies in urban regeneration fields

Learning Structured Inference Neural Networks with Label Relations

Images of scenes have various objects as well as abundant attributes, and diverse levels of visual categorization are possible. A natural image could be assigned with fine-grained labels that describe major components, coarse-grained labels that depict high level abstraction or a set of labels that reveal attributes. Such categorization at different concept layers can be modeled with label graphs encoding label information. In this paper, we exploit this rich information with a state-of-art deep learning framework, and propose a generic structured model that leverages diverse label relations to improve image classification performance. Our approach employs a novel stacked label prediction neural network, capturing both inter-level and intra-level label semantics. We evaluate our method on benchmark image datasets, and empirical results illustrate the efficacy of our model.Comment: Conference on Computer Vision and Pattern Recognition(CVPR) 201

Investigation of Major Intermolecular Interactions in 7,8-dihydrobenzo(k)phenanthridin-6(5H)-one Crystal Using Quantum Calculations and Crystallographic Visualization Programs

Currently, tablets and capsules are the most common ways of delivering drugs. The active pharmaceutical ingredients and excipients used to make those tablets and capsules are in their crystalline form generally. However, a single molecule can form multiple different crystal structures because of different packing arrangements of the molecules. These different crystal structures have identical chemical composition but different properties such as solubility, density, stability, etc. This phenomenon is called polymorphism. Occurrence of polymorphism could be a disaster for both patients and pharmaceutical companies, as the drug could lose its efficacy due to changes in properties. Studying intermolecular interactions in crystals can give us a better understanding of how and why molecules pack together in a certain way. In this research, 7,8-dihydrobenzo(k)phenanthridin-6(5H)-one is the molecule investigated. Its crystal data files were obtained from the Cambridge Crystallographic Data Centre. A crystallographic visualization program called Mercury was used to observe all contact modes and measure distances between atoms. Quantum calculations were performed using Density Functional Theory. Then, Fukui functions and electrostatic potentials for both the crystal and the molecule were calculated. These properties were mapped on the molecule’s Hirshfeld surface and on molecular slices using OpenDX software to help visualize intermolecular interactions. Comparison between crystals and molecules was performed to observe how these properties change when molecules form crystals. These mapped properties were helpful to analyze major intermolecular interactions, but further analysis on other compounds is needed in order to fully explain molecular packing in crystals and predict crystal structures

Taraxerol exerts potent anticancer effects via induction of apoptosis and inhibition of Nf-kB signalling pathway in human middle ear epithelial cholesteatoma cells

Purpose: To investigate the effect of taraxerol on the proliferation of middle ear epithelial cholesteatoma cells.Methods: The anti-proliferative effect of taraxerol was investigated by cell counting kit-8 (CCK8) and clonogenic assays. Apoptosis was measured using DAPI, while mitochondrial membrane potential was determined with the aid of rhodamine 123 staining. Protein expression was studied by western blotting.Results: Taraxerol induced concentration-dependent anti-proliferative effects on the middle ear epithelial cholesteatoma cells, and also inhibited their colony formation potential. The drug induced apoptosis in the middle ear epithelial cholesteatoma cells by reducing mitochondrial membrane potential, and also triggered sub-G1 cell cycle arrest in these cells. Moreover, taraxerol inhibited the expression of Nf-kB.Conclusion: These findings reveal that taraxerol may be a potential lead compound for the treatment of middle ear cholesteatoma.Keywords: Cholesteatoma, Epithelial tissues, Taraxerol, Apoptosis, Cell cycle arres

Doping-free complementary WSe2 circuit via van der Waals metal integration.

Two-dimensional (2D) semiconductors have attracted considerable attention for the development of ultra-thin body transistors. However, the polarity control of 2D transistors and the achievement of complementary logic functions remain critical challenges. Here, we report a doping-free strategy to modulate the polarity of WSe2 transistors using same contact metal but different integration methods. By applying low-energy van der Waals integration of Au electrodes, we observed robust and optimized p-type transistor behavior, which is in great contrast to the transistors fabricated on the same WSe2 flake using conventional deposited Au contacts with pronounced n-type characteristics. With the ability to switch majority carrier type and to achieve optimized contact for both electrons and holes, a doping-free logic inverter is demonstrated with higher voltage gain of 340, at the bias voltage of 5.5 V. Furthermore, the simple polarity control strategy is extended for realizing more complex logic functions such as NAND and NOR

On-chip electro-optic tuning of a lithium niobate microresonator with integrated in-plane microelectrodes

We demonstrate electro-optic tuning of an on-chip lithium niobate microresonator with integrated in-plane microelectrodes. First two metallic microelectrodes on the substrate were formed via femtosecond laser process. Then a high-Q lithium niobate microresonator located between the microelectrodes was fabricated by femtosecond laser direct writing accompanied by focused ion beam milling. Due to the efficient structure designing, high electro-optical tuning coefficient of 3.41 pm/V was observed.Comment: 6 pages, 3 figure