Response: New neurons from old beliefs in the adult piriform cortex? A Commentary on: 'Occurrence of new neurons in the piriform cortex'

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Uptake of Retrograde Tracers by Intact Optic Nerve Axons: A New Way to Label Retinal Ganglion Cells

Retrograde labelling of retinal ganglion cells with optic nerve transection often leads to degeneration of ganglion cells in prolonged experiments. Here we report that an intact optic nerve could uptake retrograde tracers applied onto the surface of the nerve, leading to high efficiency labelling of ganglion cells in the retina with long-term survival of cells. This method labelled a similar number of ganglion cells (2289 +/- 174 at 2 days) as the retrograde labeling technique from the superior colliculus (2250 +/- 94) or optic nerve stump (2279 +/- 114) after transection. This finding provides an alternative way to label retinal ganglion cells without damaging the optic tract. This will facilitate anatomical studies in identifying the morphology and connectivity of retinal ganglion cells, allowing secondary or triple labelling manipulations for long-term investigations.published_or_final_versio

Joint inversion of surface waves and teleseismic body waves across the Tibetan collision zone: The fate of subducted Indian lithosphere

We carry out a joint inversion of surface wave dispersion curves and teleseismic shear wave arrival times across the Tibetan collision zone, from just south of the Himalaya to the Qaidam Basin at the northeastern margin of the plateau, and from the surface to 600 km depth. The surface wave data consist of Rayleigh-wave group dispersion curves, mainly in the period range from 10 to 70 s, with a maximum of 2877 source–receiver pairs. The body wave data consist of more than 8000 S-wave arrival times recorded from 356 telesesmic events. The tomographic images show a ‘wedge’ of fast seismic velocities beneath central Tibet that starts underneath the Himalaya and reaches as far as the Bangong–Nujiang Suture (BNS). In our preferred interpretation, in central Tibet the Indian lithosphere underthrusts the plateau to approximately the BNS, and then subducts steeply. Further east, Indian lithosphere appears to be subducting at an angle of ∼45°. We see fast seismic velocities under much of the plateau, as far as the BNS in central Tibet, and as far as the Xiangshuihe-Xiaojiang Fault in the east. At 150 km depth, the fast region is broken by an area ∼300 km wide that stretches from the northern edge of central Tibet southeastwards as far as the Himalaya. We suggest that this gap, which has been observed previously by other investigators, represents the northernmost edge of the Indian lithosphere, and is a consequence of the steepening of the subduction zone from central to eastern Tibet. This also implies that the fast velocities in the northeast have a different origin, and are likely to be caused by lithospheric thickening or small-scale subduction of Asian lithosphere. Slow velocities observed to the south of the Qaidam suggest that the basin is not subducting. Finally, we interpret fast velocities below 400 km as subducted material from an earlier stage of the collision that has stalled in the transition zone. Its position to the south of the present subduction is likely to be due to the relative motion of India to the northeast.Our study has included data from GSN (including IC, IU and II), China Digital Seismograph Network, GEOSCOPE, IRIS-IDA, Pacific-21, Kyrgyz Digital Network, Kyrgyz Seismic Telemetry Network and IRIS-USGS permanent seismic networks and the MANAS, Tien Shan Continental Dynamics, Tibetan Plateau Broadband Experiment, INDEPTH II, INDEPTH III, INDEPTH IV/ASCENT, HIMNT, Bhutan, Nanga Parbat Pakistan and GHENGIS PASSCAL temporary seismic deployments. We thank IIEES and LGIT for seismic data from Iran and also SEISUK for provision and assistance with instruments operated in northeast India. CN was supported by a Natural Environment Research Council studentship (grant NE/H52449X/1), with CASE funding from AWE Blacknest. We thank Nick Rawlinson and an anonymous reviewer for their constructive and helpful reviews. Figures were prepared with Generic Mapping Tools (GMT) software (Wessel & Smith 1998).This is the version of record, which can also be found on the publisher's website at: http://gji.oxfordjournals.org/content/198/3/1526.full © The Authors 2014. Published by Oxford University Press on behalf of The Royal Astronomical Societ

Analysis of dissipation of a burst-type martensite transformation in a Fe-Mn alloy by internal friction measurements

Recently, we have proposed a theory to analyze the first-order phase transition (FOPT) in solids. In order to test the concept of the physics of dissipation during FOPT in solids, it is necessary to test the theory with different FOPT system. We study here a burst-type martensite transformation in a Fe-18.8% Mn alloy sample for this purpose. We investigate the characteristics of γ(fcc)⇌ɛ(hcp) transformation in this alloy and measure the dependence of internal friction (IF) during γ/ɛ transformation in varying rate of temperature Ṫ and vibration frequency ω. For free oscillations, the IF was defined to be Qδ-1=δ/π where δ is the logarithmic decrement. For general (forced) oscillations, IF is usually defined to be Qw-1=(1/2π)(ΔW/W), where ΔW is the dissipation over one cycle, while W is the maximum stored energy. During our analysis, the relation between Qδ-1 and Qw-1 is deduced. The parameter l (coupling factor between phase interface and oscillating stress) takes a small value (0.015–0.035) during PT, but takes a large value (0.86) during static state. The parameter n (exponent of rate for effective PT driving force) takes a large value 0.33 during heating and 0.47 during cooling. The physical meaning of n and l is discussed. The methodology introduced here appears to be an effective way of studying FOPT in solids. © 1996 The American Physical Society.published_or_final_versio

Specialized Vasculature in the Rostral Migratory Stream as a Neurogenic Niche and Scaffold for Neuroblast Migration

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Longitudinal 1H MRS of hamster superior colliculus following retinotectal deafferentation

Session: Applications of MRS to the Animal Brain - TRADpublished_or_final_versionThe 17th Scientific Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM 2009), Honlolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 200

A Self-assembling Nanomaterial Reduces Acute Brain Injury and Enhances Functional Recovery in a Rat Model of Hypertensive Intracerebral Hemorrhage

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Image processing methods to elucidate spatial characteristics of retinal microglia after optic nerve transection

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Nano hemostat solution: immediate hemostasis at the nanoscale

Hemostasis is a major problem in surgical procedures and after major trauma. There are few effective methods to stop bleeding without causing secondary damage. We used a self-assembling peptide that establishes a nanofiber barrier to achieve complete hemostasis immediately when applied directly to a wound in the brain, spinal cord, femoral artery, liver, or skin of mammals. This novel therapy stops bleeding without the use of pressure, cauterization, vasoconstriction, coagulation, or cross-linked adhesives. The self-assembling solution is nontoxic and nonimmunogenic, and the breakdown products are amino acids, which are tissue building blocks that can be used to repair the site of injury. Here we report the first use of nanotechnology to achieve complete hemostasis in less than 15 seconds, which could fundamentally change how much blood is needed during surgery of the future. © 2006.postprin

Electric Field Effects on Graphene Materials

Understanding the effect of electric fields on the physical and chemical properties of two-dimensional (2D) nanostructures is instrumental in the design of novel electronic and optoelectronic devices. Several of those properties are characterized in terms of the dielectric constant which play an important role on capacitance, conductivity, screening, dielectric losses and refractive index. Here we review our recent theoretical studies using density functional calculations including van der Waals interactions on two types of layered materials of similar two-dimensional molecular geometry but remarkably different electronic structures, that is, graphene and molybdenum disulphide (MoS$_2$). We focus on such two-dimensional crystals because of they complementary physical and chemical properties, and the appealing interest to incorporate them in the next generation of electronic and optoelectronic devices. We predict that the effective dielectric constant ($\varepsilon$) of few-layer graphene and MoS$_2$ is tunable by external electric fields ($E_{\rm ext}$). We show that at low fields ($E_{\rm ext}^{}<0.01$ V/\AA) $\varepsilon$ assumes a nearly constant value $\sim$4 for both materials, but increases at higher fields to values that depend on the layer thickness. The thicker the structure the stronger is the modulation of $\varepsilon$ with the electric field. Increasing of the external field perpendicular to the layer surface above a critical value can drive the systems to an unstable state where the layers are weakly coupled and can be easily separated. The observed dependence of $\varepsilon$ on the external field is due to charge polarization driven by the bias, which show several similar characteristics despite of the layer considered.Comment: Invited book chapter on Exotic Properties of Carbon Nanomatter: Advances in Physics and Chemistry, Springer Series on Carbon Materials. Editors: Mihai V. Putz and Ottorino Ori (11 pages, 4 figures, 30 references