Scintillation detectors constructed with an optimized 2x2 silicon photomultiplier array

Silicon photomultipliers (SiPMs) are a good alternative to photomultiplier tubes (PMTs) because their gain and quantum efficiency are comparable to PMTs. However, the largest single-chip SiPM is still less than 1~cm$^2$. In order to use SiPMs with scintillators that have reasonable sensitivity, it is necessary to use multiple SiPMs. In this work, scintillation detectors are constructed and tested with a custom 2x2 SiPM array. The layout of the SiPMs and the geometry of the scintillator were determined by performing Geant4 simulations. Cubic NaI, CsI, and CLYC with 18~mm sides have been tested. The output of the scintillation detectors are stabilized over the temperature range between --20 and 50~$^{\circ}$C by matching the gain of the SiPMs in the array. The energy resolution for these detectors has been measured as a function of temperature. Furthermore, neutron detection for the CLYC detector was studied in the same temperature range. Using pulse-shape discrimination, neutrons can be cleanly identified without contribution from $\gamma$-photons. As a result, these detectors are suitable for deploying in spectroscopic personal radiation detectors (SPRD).Comment: IEEE Nuclear Science Symposium Conference Record (2016

Evolutionary neural architecture search for deep learning

Deep neural networks (DNNs) have produced state-of-the-art results in many benchmarks and problem domains. However, the success of DNNs depends on the proper configuration of its architecture and hyperparameters. DNNs are often not used to their full potential because it is difficult to determine what architectures and hyperparameters should be used. While several approaches have been proposed, computational complexity of searching large design spaces makes them impractical for large modern DNNs. This dissertation introduces an efficient evolutionary algorithm (EA) for simultaneous optimization of DNN architecture and hyperparameters. It builds upon extensive past research of evolutionary optimization of neural network structure. Various improvements to the core algorithm are introduced, including: (1) discovering DNN architectures of arbitrary complexity; (1) generating modular, repetitive modules commonly seen in state-of-the-art DNNs; (3) extending to the multitask learning and multiobjective optimization domains; (4) maximizing performance and reducing wasted computation through asynchronous evaluations. Experimental results in image classification, image captioning, and multialphabet character recognition show that the approach is able to evolve networks that are competitive with or even exceed hand-designed networks. Thus, the method enables an automated and streamlined process to optimize DNN architectures for a given problem and can be widely applied to solve harder tasks.Computer Science

To Tube or Not to Tube? The Role of Intubation during Stroke Thrombectomy.

In the 10 years since the FDA first cleared the use of endovascular devices for the treatment of acute stroke, definitive evidence that such therapy improves outcomes remains lacking. The decision to intubate patients undergoing stroke thrombectomy impacts multiple variables that may influence outcomes after stroke. Three main areas where intubation may deleteriously affect acute stroke management include the introduction of delays in revascularization, fluctuations in peri-procedural blood pressure, and hypocapnia, resulting in cerebral vasoconstriction. In this mini-review, we discuss the evidence supporting these limitations of intubation during stroke thrombectomy and encourage neurohospitalists, neurocritical care specialists, and neurointerventionalists to carefully consider the decision to intubate during thrombectomy and provide strategies to avoid potential complications associated with its use in acute stroke

Applications of the Oriented Permission Role-Based Access Control Model

Role-based access control and role hierarchies have been the subject of considerable research in recent years. In this paper, we consider three useful applications of a new role-based access control model that contains a novel approach to permissions and permission inheritance: one is to illustrate that the new model provides a simpler and more natural way to implement BLP model using role-based techniques; a second application is to make it possible to define separation of duty constraints on two roles that have a common senior role and for a user to be assigned to or activate the senior role; finally, we describe how a single hierarchy in the new model can support the distinction between role activation and permission usage. In short, the oriented permission model provides ways of implementing a number of useful features that have previously required ad hoc and inelegant solutions

Local auxin transport regulation in the nascent nodule - an overview in nodulating plants and an investigation into the cytokinin receptor, cre1 - mediated control of auxin transport in medicago truncatula

Legumes form a symbiotic relationship with a group of bacteria, collectively known as rhizobia. The bacterial symbiont fixes atmospheric nitrogen within root nodules, thus providing the host with an assimilative nitrogen source. Nodule formation involves a complex signalling pathway within the legume host. The plant hormone auxin is involved in nodule organogenesis, but how auxin regulates nodulation is still poorly described. Several studies have found increased auxin signalling in nodule primordia, but so far auxin metabolites have never been quantified during the early stages of nodulation. Therefore, the first aim of this thesis was to establish methods for auxin quantification in legume roots. The presumed build-up of auxin in nodule primordia has been predicted to be due to inhibition of auxin export from cells at the nodule initiation site, but the regulation of auxin transport has not been tested systematically in different legumes. Therefore, the second aim was to compare auxin concentrations and auxin transport changes during nodulation in different legumes. Third, the regulation of auxin transport and auxin accumulation was placed into the known signalling pathway of nodulation in the model legume, Medicago truncatula. Auxins are naturally present in low quantities in the root. We developed an LC-MS/MS method for the accurate and sensitive quantification of auxins in root tissues. The method was validated and produced sensitive limits of detection / quantification and correlation coefficients. To compare the role of auxin between indeterminate and determinate nodule types, we measured auxin transport and auxin content in M. truncatula (forming indeterminate nodules) and Lotus japonicus (forming determinate nodules). In addition to acropetal auxin transport, basipetal auxin transport was regulated in response to rhizobia inoculation in both legumes. Different auxins with distinct levels of abundance were detected in separate legumes, with some unique to the nodule tissues. Auxin concentrations increased at the early stages of nodule formation in M. truncatula, but not Lotus japonicus. The inhibition of acropetal polar auxin transport by rhizobia occurred only in indeterminate nodule-forming legumes and correlated with the ability of synthetic auxin transport inhibitors to induce pseudonodules in those legumes. Finally, we investigated the role of the cytokinin receptor CRE1 in modulating auxin transport during nodulation in M. truncatula. We found that cytokinin signalling through CRE1 is necessary for inhibition of acropetal auxin transport, increased auxin concentration and auxin signalling in response to rhizobia. The CRE1 receptor was also required for the correct induction of several flavonoids, which could act as endogenous auxin transport inhibitors. External application of those flavonoids rescued nodulation in the cre1 nodulation-deficient mutant. In conclusion, we demonstrated that the auxin transport machinery is a crucial component in the host legume that is regulated in response to rhizobia. Auxin transport changes could explain measured changes in auxin concentrations during nodule initiation of M. truncatula, but not L. japonicus. Auxin transport control is mediated by endogenous flavonoids, and both flavonoid induction and auxin transport control are regulated by cytokinin signalling in M. truncatula