2,390 research outputs found
Rational spectral methods for PDEs involving fractional Laplacian in unbounded domains
Many PDEs involving fractional Laplacian are naturally set in unbounded
domains with underlying solutions decay very slowly, subject to certain power
laws. Their numerical solutions are under-explored. This paper aims at
developing accurate spectral methods using rational basis (or modified mapped
Gegenbauer functions) for such models in unbounded domains. The main building
block of the spectral algorithms is the explicit representations for the
Fourier transform and fractional Laplacian of the rational basis, derived from
some useful integral identites related to modified Bessel functions. With these
at our disposal, we can construct rational spectral-Galerkin and direct
collocation schemes by pre-computing the associated fractional differentiation
matrices. We obtain optimal error estimates of rational spectral approximation
in the fractional Sobolev spaces, and analyze the optimal convergence of the
proposed Galerkin scheme. We also provide ample numerical results to show that
the rational method outperforms the Hermite function approach
A loss-of-function allele of OsHMA3 associated with high cadmium accumulation in shoots and grain of Japonica rice cultivars
This article is protected by copyright. All rights reserved.Peer reviewedPostprin
Clinical features of neovascular glaucoma treated with multi-wavelength laser photocoagulation
AIM: To observe clinical features of neovascular glaucoma(NVG)treated with multi-wavelength laser photocoagulation(PRP). <p>METHODS: Totally 21 patients(25 eyes)with NVG were performed actively anti-glaucoma treatment, at the same time, they were also performed multi-wavelength laser photocoagulation. Photocoagulation characteristics and complications were observed.<p>RESULTS: The PRP was completed successfully on alleyes. Red photocoagulation was used more offen. Three cases(5 eyes)had obvious pain, 2 cases(3 eyes)had iris inflammation reaction, 4 cases(4 eyes)had anterior chamber and vitreous hemorrhage. Choroidal retinal detachment was not found. IOP was decreased at different degree, eye pain and headache symptoms were relieved. <p>CONCLUSION: Multi-wavelength laser is conducive to the successful completion of pan retinal photocoagulation in neovascular glaucoma. It is safe and effective
Epigenetics in ovarian cancer: premise, properties, and perspectives.
Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality. Therefore, it is both urgent and important to identify biomarkers facilitating early identification and novel agents preventing recurrence. Accumulating evidence demonstrates that epigenetic aberrations (particularly histone modifications) are crucial in tumor initiation and development. Histone acetylation and methylation are respectively regulated by acetyltransferases-deacetylases and methyltransferases-demethylases, both of which are implicated in ovarian cancer pathogenesis. In this review, we summarize the most recent discoveries pertaining to ovarian cancer development arising from the imbalance of histone acetylation and methylation, and provide insight into novel therapeutic interventions for the treatment of ovarian carcinoma
7-Piperazinethylchrysin inhibits melanoma cell proliferation by targeting Mek 1/2 kinase activity
Purpose: To investigate the growth-inhibitory effect of 7-piperazinethylchrysin (PEC) on melanoma cell lines.Methods: Cell viability was analyzed by trypan blue exclusion assays and the cell cycle by flow cytometry using ModFit LT software. Specifically, cells were stained with propidium iodide (0.5 mg/mL) supplemented with RNase A (50 mg/mL), and analyzed using flow cytometry and ModFit LT software.Results: In A375 and B16F10 cell cultures, proliferation was reduced to 79 and 72 %, respectively, on treatment with 30 μM PEC. PEC increased the proportion of A375 cells in G1/G0 phase to 71.23 %, versus 42.76 % in untreated cells. In B16F10 and A375 cells, treatment with PEC caused the inhibition of Mek 1/2 kinase activity and suppressed Erk 1/2 phosphorylation. The level of cAMP-response element binding protein was increased by PEC. The expression of microphthalmia-linked transcription factor was also increased by PEC treatment. Marked enhancement was observed in the level of tyrosinase in melanoma cells on treatment with PEC. Analysis of PBG-D expression showed a marked increase in B16F10 and A375 cells on the addition of PEC to cell cultures at 72 h. The level of PBG D expression was increased by 9- and 8.5-fold in B16F10 and A375 cells, respectively, on incubation with 30 μM PEC. The addition of a Mek 1/2 inhibitor (U0126) to the cultures promoted PEC-mediated growth inhibition.Conclusion: PEC inhibited melanoma cell proliferation, apparently by blocking the cell cycle at G0/G1 and downregulating the Ras/Raf/Mek/Erk pathway.Keywords: Tyrosinase, Kinase, Microphthalmia, Phosphorylation, 7-Piperazinethylchrysi
Post-treatment techniques for enhancing mode-coupling in long period fiber gratings induced by CO2 laser
Nanoscale polysaccharide derivative as an AEG-1 siRNA carrier for effective osteosarcoma therapy
Poly[[tetraaqua-μ4-fumarato-di-μ3-fumarato-dineodymium(III)] trihydrate]
The title coordination polymer, {[Nd2(C4H2O4)3(H2O)4]·3H2O}, was synthesized by the reaction of neodymium(III) nitrate hexahydrate with fumaric acid in a water–methanol (7:3) solution. The asymmetric unit comprises two Nd3+ cations, three fumarate dianions (L
2−), four aqua ligands and three uncoordinated water molecules. The carboxylate groups of the fumarate dianions exhibit different coordination modes. In one fumarate dianion, two carboxylate groups chelate two Nd3+ cations, while one of the O atoms is coordinated to another Nd3+ cation. Another fumarate dianion bridges three Nd3+ cations: one of the carboxylate groups chelates one Nd3+ cation, while the other carboxylate group bridges two Nd3+ cations in a monodentate mode. The third fumarate dianion bridges four Nd3+ cations, where one of the carboxylate groups chelates one Nd3+ cation and coordinates in a monodentate mode to a second Nd3+, while the second carboxylate groups bridges two Nd3+ cations in a monodentate mode and one O atom is coordinated to one Nd3+ cation. The Nd3+ cations are in a distorted tricapped–trigonal prismatic environment and coordinated by seven O atoms from the fumarate ligands and two O atoms from water molecules. The Nd3+ cations are linked by two carboxylate O atoms and two carboxylate groups, generating infinite Nd–O chains to form a three-dimensional framework. There are O—H⋯O and C—H⋯O hydrogen-bonding interactions between the coordinated and uncoordinated water molecules and carboxylate O atoms
A Common Variant in CLDN14 is Associated with Primary Biliary Cirrhosis and Bone Mineral Density.
Primary biliary cirrhosis (PBC), a chronic autoimmune liver disease, has been associated with increased incidence of osteoporosis. Intriguingly, two PBC susceptibility loci identified through genome-wide association studies are also involved in bone mineral density (BMD). These observations led us to investigate the genetic variants shared between PBC and BMD. We evaluated 72 genome-wide significant BMD SNPs for association with PBC using two European GWAS data sets (n = 8392), with replication of significant findings in a Chinese cohort (685 cases, 1152 controls). Our analysis identified a novel variant in the intron of the CLDN14 gene (rs170183, Pfdr = 0.015) after multiple testing correction. The three associated variants were followed-up in the Chinese cohort; one SNP rs170183 demonstrated consistent evidence of association in diverse ethnic populations (Pcombined = 2.43 × 10(-5)). Notably, expression quantitative trait loci (eQTL) data revealed that rs170183 was correlated with a decline in CLDN14 expression in both lymphoblastoid cell lines and T cells (Padj = 0.003 and 0.016, respectively). In conclusion, our study identified a novel PBC susceptibility variant that has been shown to be strongly associated with BMD, highlighting the potential of pleiotropy to improve gene discovery
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