The Higgs boson inclusive decay channels H→bbˉH \to b\bar{b} and H→ggH \to gg up to four-loop level

The principle of maximum conformality (PMC) has been suggested to eliminate the renormalization scheme and renormalization scale uncertainties, which are unavoidable for the conventional scale setting and are usually important errors for theoretical estimations. In this paper, by applying PMC scale setting, we analyze two important inclusive Standard Model Higgs decay channels, $H\rightarrow b\bar{b}$ and $H\rightarrow gg$, up to four-loop and three-loop levels accordingly. After PMC scale setting, it is found that the conventional scale uncertainty for these two channels can be eliminated to a high degree. There is small residual initial scale dependence for the Higgs decay widths due to unknown higher-order $\{\beta_i\}$-terms. Up to four-loop level, we obtain $\Gamma(H\rightarrow b\bar{b}) = 2.389\pm0.073 \pm0.041$ MeV and up to three-loop level, we obtain $\Gamma(H\rightarrow gg) = 0.373\pm0.030$ MeV, where the first error is caused by varying $M_H=126\pm4$ GeV and the second error for $H\to b\bar{b}$ is caused by varying the $\overline{\rm MS}$-running mass $m_b(m_b)=4.18\pm0.03$ GeV. Taking $H\to b\bar{b}$ as an example, we present a comparison of three BLM-based scale setting approaches, e.g. the PMC-I approach based on the PMC-BLM correspondence, the $R_\delta$-scheme and the seBLM approach, all of which are designed to provide effective ways to identify non-conformal $\{\beta_i\}$-series at each perturbative order. At four-loop level, all those approaches lead to good pQCD convergence, they have almost the same pQCD series, and their predictions are almost independent on the initial renormalization scale. In this sense, those approaches are equivalent to each other.Comment: 14 pages, 7 figures. References updated and discussions improved. To be published in Eur.Phys.J.

Label-free quantitative proteomics of CD133-positive liver cancer stem cells

Abstract Background CD133-positive liver cancer stem cells, which are characterized by their resistance to conventional chemotherapy and their tumor initiation ability at limited dilutions, have been recognized as a critical target in liver cancer therapeutics. In the current work, we developed a label-free quantitative method to investigate the proteome of CD133-positive liver cancer stem cells for the purpose of identifying unique biomarkers that can be utilized for targeting liver cancer stem cells. Label-free quantitation was performed in combination with ID-based Elution time Alignment by Linear regression Quantitation (IDEAL-Q) and MaxQuant. Results Initially, IDEAL-Q analysis revealed that 151 proteins were differentially expressed in the CD133-positive hepatoma cells when compared with CD133-negative cells. We then analyzed these 151 differentially expressed proteins by MaxQuant software and identified 10 significantly up-regulated proteins. The results were further validated by RT-PCR, western blot, flow cytometry or immunofluorescent staining which revealed that prominin-1, annexin A1, annexin A3, transgelin, creatine kinase B, vimentin, and EpCAM were indeed highly expressed in the CD133-positive hepatoma cells. Conclusions These findings confirmed that mass spectrometry-based label-free quantitative proteomics can be used to gain insights into liver cancer stem cells.http://deepblue.lib.umich.edu/bitstream/2027.42/113089/1/12953_2012_Article_407.pd

UGROŽENE VRSTE RIBA U SVIJETU: Hucho taimen (Pallas, 1773)

Taimen Hucho taimen (Pallas, 1773) was once common in China, Russia, Kazakhstan and Mongolia but is disappearing now from its native region. This vulnerable species has considerable ecological importance but there are few data available on its biology. The limited available data on its systematics, distribution, ecology, reproduction and threats are summarized and discussed.Taimen Hucho taimen (Pallas, 1773) je nekoć bio čest u Kini, Rusiji, Kazahstanu i Mongoliji, ali sada nestaje iz svojih prirodnih staništa. Ova osjetljiva vrsta ima značajnu ekološku važnost iako ima malo podataka o njenoj biologiji. Dostupni podaci vezani uz sistematiku, distribuciju, ekologiju, razmnožavanje i prijetnje su ograničeni te su sažeti i o njima se raspravlja

Simulation analysis on the round billet macrostructure of special steel vertical caster

Ovaj rad daje analizu okruglog trupca 42CrMo vertikalno ljevanog. Temelji se na parametrima procesa kontinuiranog lijevanja ZhongYuan specijalnog čelika i parametrima CAFE nukleacije, usvojenom metodom "ProCAST chip-moving boundary" za provođenje numeričke simulacije okruglog trupca. Simulacijski i praktični slučajevi imaju istu makrostrukturnu morfologiju, okrugla kladica ima središnji istoosni kristal od 41,2 %. Kako je smanjeno pregrijavanje tekućeg čelika i intenziteta hlađenja, prosječni radijus kristala se smanjio, broj kristala se povećao, a makrostruktura je pokazala trend progresivnog razrađivanja.This paper provides an analysis of the 42CrMo round billet by the vertical caster. Based on ZhongYuan Special Steel continuous casting process parameters and CAFE nucleation parameters, the ProCAST chip-moving boundary method is adopted to conduct the numerical simulation of round billet. Simulation and practical cases both have the same macrostructure morphology, the round billet has the center equiaxial crystal of 41,2 %. As the superheat of liquid steel and cooling intensity is reduced, the average radius of crystal decreased, the number of crystal increased, and the macrostructure showed a trend of progressive elaboration

Return of 4U~1730--22 after 49 years silence: the peculiar burst properties of the 2021/2022 outbursts observed by Insight-HXMT

After in quiescence for 49 years, 4U~1730--22 became active and had two outbursts in 2021 \& 2022; ten thermonuclear X-ray bursts were detected with Insight-HXMT. Among them, the faintest burst showed a double-peaked profile, placing the source as the 5th accreting neutron star (NS) exhibiting double/triple-peaked type-I X-ray bursts; the other bursts showed photospheric radius expansion (PRE). The properties of double-peaked non-PRE burst indicate that it could be related to a stalled burning front. For the five bright PRE bursts, apart from the emission from the neutron star (NS) surface, we find the residuals both in the soft ($$10 keV) X-ray band. Time-resolved spectroscopy reveals that the excess can be attributed to an enhanced pre-burst/persistent emission or the Comptonization of the burst emission by the corona/boundary-layer. We find, the burst emission shows a rise until the photosphere touches down to the NS surface rather than the theoretical predicted constant Eddington luminosity. The shortage of the burst emission in the early rising phase is beyond the occlusion by the disk. We speculate that the findings above correspond to that the obscured part (not only the lower part) of the NS surface is exposed to the line of sight due to the evaporation of the obscured material by the burst emission, or the burst emission is anisotropic ($\xi>1$) in the burst early phase. In addition, based on the average flux of PRE bursts at their touch-down time, we derive a distance estimation as 10.4 kpc.Comment: arXiv admin note: substantial text overlap with arXiv:2208.13556; text overlap with arXiv:2208.1212

Detection of the inferred interaction network in hepatocellular carcinoma from EHCO (Encyclopedia of Hepatocellular Carcinoma genes Online)

BACKGROUND: The significant advances in microarray and proteomics analyses have resulted in an exponential increase in potential new targets and have promised to shed light on the identification of disease markers and cellular pathways. We aim to collect and decipher the HCC-related genes at the systems level. RESULTS: Here, we build an integrative platform, the Encyclopedia of Hepatocellular Carcinoma genes Online, dubbed EHCO , to systematically collect, organize and compare the pileup of unsorted HCC-related studies by using natural language processing and softbots. Among the eight gene set collections, ranging across PubMed, SAGE, microarray, and proteomics data, there are 2,906 genes in total; however, more than 77% genes are only included once, suggesting that tremendous efforts need to be exerted to characterize the relationship between HCC and these genes. Of these HCC inventories, protein binding represents the largest proportion (~25%) from Gene Ontology analysis. In fact, many differentially expressed gene sets in EHCO could form interaction networks (e.g. HBV-associated HCC network) by using available human protein-protein interaction datasets. To further highlight the potential new targets in the inferred network from EHCO, we combine comparative genomics and interactomics approaches to analyze 120 evolutionary conserved and overexpressed genes in HCC. 47 out of 120 queries can form a highly interactive network with 18 queries serving as hubs. CONCLUSION: This architectural map may represent the first step toward the attempt to decipher the hepatocarcinogenesis at the systems level. Targeting hubs and/or disruption of the network formation might reveal novel strategy for HCC treatment