Glueball Masses from Hamiltonian Lattice QCD

We calculate the masses of the $0^{++}$, $0^{--}$ and $1^{+-}$ glueballs from QCD in 3+1 dimensions using an eigenvalue equation method for Hamiltonian lattice QCD developed and described elsewhere by the authors. The mass ratios become approximately constants in the coupling region $6/g^2 \in [6.0,6.4]$, from which we estimate $M(0^{--})/M(0^{++})=2.44 \pm 0.05 \pm 0.20$ and $M(1^{+-})/M(0^{++})=1.91 \pm 0.05 \pm 0.12$.Comment: 12 pages, Latex, figures to be sent upon reques

Six New Species and 1 New Species Record of Orthotrichia (Trichoptera: Hydroptilidae) from China

Six new species of the caddisfly genus Orthotrichia are described and illustrated from China, namely Or. apophysis Zhou & Yang, sp. nov.; Or. latiramifera Zhou & Yang, sp. nov.; Or. cornuta Zhou &Yang, sp. nov.; Or. discedata Zhou & Morse, sp. nov.; Or. cuspidigera Zhou & Yang, sp. nov.; and Or. subrhomba Zhou & Morse, sp. nov.. One species, Or. terpsichore Malicky & Chantaramongkol, 2007, is recorded for the first time from China, bringing the number of species of the genus known from China to 14. Of these, 10 species are distributed among 3 species groups of Marshall (1979), with 4 species unassigned. The known distributions for all the Chinese Orthotrichia species are provided

Near-infrared photoactivatable control of Ca signaling and optogenetic immunomodulation

The application of current channelrhodopsin-based optogenetic tools is limited by the lack of strict ion selectivity and the inability to extend the spectra sensitivity into the near-infrared (NIR) tissue transmissible range. Here we present an NIR-stimulable optogenetic platform (termed Opto-CRAC ) that selectively and remotely controls Ca2+ oscillations and Ca2+-responsive gene expression to regulate the function of non-excitable cells, including T lymphocytes, macrophages and dendritic cells. When coupled to upconversion nanoparticles, the optogenetic operation window is shifted from the visible range to NIR wavelengths to enable wireless photoactivation of Ca2+-dependent signaling and optogenetic modulation of immunoinflammatory responses. In a mouse model of melanoma by using ovalbumin as surrogate tumor antigen, Opto-CRAC has been shown to act as a genetically-encoded photoactivatable adjuvant to improve antigen-specific immune responses to specifically destruct tumor cells. Our study represents a solid step forward towards the goal of achieving remote control of Ca2+-modulated activities with tailored function

Study on the process of Belgian style Cherry sour beer

Traditional sour beer is not acceptable to everyone, but sweet and sour beer is much more acceptable. For example, many sour beers are made with cherries, raspberries and other ingredients. Belgian style cherry sour beer, on the basis of acidizing process, add fruit raw materials to continue fermentation, taste and flavor acceptable degree will be much higher than ordinary sour beer, because these fruits are more nutritious, resulting in these wines are easy to health, health and high-end. In this experiment, the production process of passion fruit cider was studied: The initial sugar content was adjusted to 12°P and the pH at the end point of acidification was 3.8. S-04 yeast was used for fermentation, and the fermentation temperature was controlled at 18℃. After one week of fermentation, the mixing ratio of cherry juice and fruit puree was 1:1.5. After continued fermentation for three days, cherry style sour beer was made with strong flavor, strong killing taste, pure body and clear cherry flavor

Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway

Background: Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), a long noncoding RNA, is significantly highly expressed and associated with metastasis and poor prognosis in many cancers, including nasopharyngeal carcinoma (NPC). In this study, we aim to identify the role of AFAP1-AS1 acting as an oncogenic lncRNA to promote NPC metastasis. Methods: The role of AFAP1-AS1, miR-423-5p, and FOSL2 in NPC metastasis was investigated in vitro and in vivo. Bioinformatics analysis and luciferase activity assays were used to identify the interaction between AFAP1-AS1, miR-423- 5p, and FOSL2. Additionally, real-time PCR and western blotting were used to assess the function of AFAP1-AS1 acting as an oncogenic lncRNA to promote NPC progression by regulating miR-423-5p and the downstream Rho/Rac pathway. Results: In this study, we determined that AFAP1-AS1 functions as a competing endogenous RNA in NPC to regulate the Rho/Rac pathway through miR-423-5p. These interactions can mediate the expression of RAB11B, LASP1, and FOSL2 and accelerate cell migration and invasion via the Rho/Rac signaling pathway or FOSL2. AFAP1-AS1 and FOSL2 could competitively bind with miR-423-5p to regulate several molecules, including RAB11B and LASP1 of the Rho/Rac signaling pathway. AFAP1-AS1 can also regulate the expression of LASP1, which was transcriptionally regulated by FOSL2, resulting in increased migration and invasion of NPC cells via the Rho/Rac signaling pathway. Conclusions: The observations in this study identify an important role for AFAP1-AS1 as a competing endogenous RNA (ceRNA) in NPC pathogenesis and indicate that it may serve as a potential target for cancer diagnosis and treatment

Impact of diurnal temperature fluctuations on larval settlement and growth of the reef coral Pocillopora damicornis

Diurnal fluctuations in seawater temperature are ubiquitous on tropical reef flats. However, the effects of such dynamic temperature variations on the early stages of corals are poorly understood. In this study, we investigated the responses of larvae and new recruits of Pocillopora damicornis to two constant temperature treatments (29 and 31 degrees C) and two diurnally fluctuating treatments (28-31 and 30-33 degrees C with daily means of 29 and 31 degrees C, respectively) simulating the 3 degrees C diel oscillations at 3m depth on the Luhuitou fringing reef (Sanya, China). Results showed that the thermal stress on settlement at 31 degrees C was almost negated by the fluctuating treatment. Further, neither elevated temperature nor temperature fluctuations caused bleaching responses in recruits, while the maximum excitation pressure over photosystem II (PSII) was reduced under fluctuating temperatures. Although early growth and development were highly stimulated at 31 degrees C, oscillations of 3 degrees C had little effects on budding and lateral growth at either mean temperature. Nevertheless, daytime encounters with the maximum temperature of 33 degrees C in fluctuating 31 degrees C elicited a notable reduction in calcification compared to constant 31 degrees C. These results underscore the complexity of the effects caused by diel temperature fluctuations on early stages of corals and suggest that ecologically relevant temperature variability could buffer warming stress on larval settlement and dampen the positive effects of increased temperatures on coral growth

Enhancing electron transport in molecular wires by insertion of a ferrocene center

National Natural Science Foundation of China [21003110, 21273204, 20803027, 21173094]We have determined the conductance of alkane-linked ferrocene molecules with carboxylic acid anchoring groups using the STM break junction technique, and three sets of conductance values were found, i.e. high conductance (HC), medium conductance (MC) and low conductance (LC) values. The enhancing effect of the incorporated ferrocene on the electron transport in saturated alkane molecular wires is demonstrated by the increased conductance of the ferrocene molecules, attributed to the reduction of the tunneling barrier and the HOMO-LUMO gap induced by the insertion of ferrocene. Furthermore, the electron-withdrawing carbonyl group on the unconjugated backbone has little or no influence on single-molecule conductance. The current work provides a feasible approach for the design of high-performance molecular wires

Diurnally Fluctuating pCO2 Modifies the Physiological Responses of Coral Recruits Under Ocean Acidification

Diurnal pCO2 fluctuations have the potential to modulate the biological impact of ocean acidification (OA) on reef calcifiers, yet little is known about the physiological and biochemical responses of scleractinian corals to fluctuating carbonate chemistry under OA. Here, we exposed newly settled Pocillopora damicornis for 7 days to ambient pCO2, steady and elevated pCO2 (stable OA) and diurnally fluctuating pCO2 under future OA scenario (fluctuating OA). We measured the photo-physiology, growth (lateral growth, budding and calcification), oxidative stress and activities of carbonic anhydrase (CA), Ca-ATPase and Mg-ATPase. Results showed that while OA enhanced the photochemical performance of in hospite symbionts, it also increased catalase activity and lipid peroxidation. Furthermore, both OA treatments altered the activities of host and symbiont CA, suggesting functional changes in the uptake of dissolved inorganic carbon (DIC) for photosynthesis and calcification. Most importantly, only the fluctuating OA treatment resulted in a slight drop in calcification with concurrent up-regulation of Ca-ATPase and Mg-ATPase, implying increased energy expenditure on calcification. Consequently, asexual budding rates decreased by 50% under fluctuating OA. These results suggest that diel pCO2 oscillations could modify the physiological responses and potentially alter the energy budget of coral recruits under future OA, and that fluctuating OA is more energetically expensive for the maintenance of coral recruits than stable OA

Prevalence of cerebral palsy comorbidities in China: a systematic review and meta-analysis

ObjectivesThis systematic review aimed to comprehensively understand the comorbidity of cerebral palsy (CP) in China.MethodsWe searched through databases in both Chinese and English until December 2022 to gather cross-sectional studies on the comorbidity of CP in China. After two reviewers independently screened the articles, collected the data, and assessed the bias risk, a meta-analysis was conducted using the Stata 17.0 software.ResultsA total of 73 articles were included. Of these, 16 articles reported total comorbidity, with a prevalence of 79.7% (95% CI: 73.8–85.7%); 56 articles reported epilepsy, with a prevalence of 17.9% (95% CI: 15.4–20.4%); 48 articles reported intellectual disability, with a prevalence of 58.0% (95% CI: 51.8–64.3%); 32 articles reported speech disorders, with a prevalence of 48.0% (95% CI: 41.6–54.4%); 41 articles reported hearing disorders, with a prevalence of 17.2% (95% CI: 13.0–21.4%); and 35 articles reported vision disorders, with a prevalence of 23.1% (95% CI: 16.3–29.8%). The topographical type of CP was the primary source of heterogeneity in the prevalence of epilepsy. Diagnostic criteria for CP, clinical type of CP, GMFCS, publishing time, and topographical type of CP were the primary sources of heterogeneity in the prevalence of intellectual disability. Clinical type of CP and topographical type were the primary sources of heterogeneity in the prevalence of speech disorders. Finally, the region was the primary source of heterogeneity in the prevalence of hearing disorders.ConclusionThe prevalence of comorbidities in CP is high in China. Comorbidities are related to the characteristics, severity, and risk factors of brain insult and have a particular relationship with regional economic development and medical and health levels