Influence of ADAM10 Polymorphisms on Plasma Level of Soluble Receptor for Advanced Glycation End Products and The Association With Alzheimer’s Disease Risk

To determine the role of A disintegrin and metalloproteinase 10 (ADAM10) in genetic susceptibility to Alzheimer’s disease (AD) in a representative Chinese sample, we genotyped 362 AD patients and 370 healthy controls for the rs514049A/C and rs653765C/T polymorphisms in the ADAM10 promoter using the SNaPshot technique. We also examined the potential impact of these polymorphisms on the plasma level of soluble receptor for advanced glycation end products (sRAGE), a decoy receptor whose reduction has been associated with a higher risk of AD. Additionally, a meta-analysis was performed using the present study and the largest GWAS from the International Genomics of Alzheimer’s Project (IGAP). No significant differences were found in the distributions of genotypes or alleles between AD patients and control subjects. However, age-at-onset stratification analysis revealed that there were significant differences in the genotypes (P = 0.015) and alleles (P = 0.006) of the rs653765 SNP. Furthermore, patients with the rs653765 CC genotype showed a lower ADAM10 level and a faster cognitive deterioration than those in patients with the CT/TT genotype in late-onset AD (LOAD), and the rs653765 CC polymorphism was able to regulate the production of the ADAM10 substrate sRAGE. In contrast, the rs514049 polymorphism was not statistically associated with AD. In the meta-analysis, we observed that both rs514049 (A allele vs. C allele, P = 0.002) and rs653765 (C allele vs. T allele, P = 0.004) were associated with AD risk. The present study indicated that the rs653765 polymorphism might be associated with the risk and development of LOAD; in particular, the risk genotype, CC, may decrease the expression of ADAM10, influencing the plasma levels of sRAGE, and thus may be correlated with the clinical progression of AD

Eradication of Helicobacter pylori

Objective. To evaluate the effect of eradication of Helicobacter pylori (H. pylori) on the progression of dementia in Alzheimer’s disease (AD) patients with peptic ulcer. Methods. Participants with the diagnosis of AD and peptic ulcer were recruited between 2001 and 2008. We examined the association between eradication of H. pylori and the progression of AD using the multiple regression models. Medication shift from Donepezil, Rivastgmine, and Galantamine to Mematine is defined as progression of dementia according to the insurance of National Health Insurance (NHI) under expert review. Results. Among the 30142 AD patients with peptic ulcers, the ratio of medication shift in AD patients with peptic ulcers is 79.95%. There were significant lower incidence comorbidities (diabetes mellitus, hypertension, cerebrovascular disease, coronary artery disease, congestive heart failure and hyperlipidemia) in patients with H. pylori eradication as compared with no H. pylori eradication. Eradication of H. pylori was associated with a decreased risk of AD progression (odds ratio [OR] 0.35 [0.23–0.52]) as compared with no H. pylori eradication, which was not modified by comorbidities. Conclusions. Eradication of H. pylori was associated with a decreased progression of dementia as compared to no eradication of H. pylori in AD patients with peptic ulcers

Israeli Acute Paralysis Virus: Epidemiology, Pathogenesis and Implications for Honey Bee Health

Israeli acute paralysis virus (IAPV) is a widespread RNA virus of honey bees that has been linked with colony losses. Here we describe the transmission, prevalence, and genetic traits of this virus, along with host transcriptional responses to infections. Further, we present RNAi-based strategies for limiting an important mechanism used by IAPV to subvert host defenses. Our study shows that IAPV is established as a persistent infection in honey bee populations, likely enabled by both horizontal and vertical transmission pathways. The phenotypic differences in pathology among different strains of IAPV found globally may be due to high levels of standing genetic variation. Microarray profiles of host responses to IAPV infection revealed that mitochondrial function is the most significantly affected biological process, suggesting that viral infection causes significant disturbance in energy-related host processes. The expression of genes involved in immune pathways in adult bees indicates that IAPV infection triggers active immune responses. The evidence that silencing an IAPV-encoded putative suppressor of RNAi reduces IAPV replication suggests a functional assignment for a particular genomic region of IAPV and closely related viruses from the Family Dicistroviridae, and indicates a novel therapeutic strategy for limiting multiple honey bee viruses simultaneously and reducing colony losses due to viral diseases. We believe that the knowledge and insights gained from this study will provide a new platform for continuing studies of the IAPV–host interactions and have positive implications for disease management that will lead to mitigation of escalating honey bee colony losses worldwide

Clopidogrel Plus Aspirin vs Aspirin Alone in Patients With Acute Mild to Moderate Stroke

Importance Dual antiplatelet therapy has been demonstrated to be superior to single antiplatelet in reducing recurrent stroke among patients with transient ischemic attack or minor stroke, but robust evidence for its effect in patients with mild to moderate ischemic stroke is lacking. Objective To evaluate whether dual antiplatelet therapy is superior to single antiplatelet among patients with mild to moderate ischemic stroke. Design, Setting, and Participants This was a multicenter, open-label, blinded end point, randomized clinical trial conducted at 66 hospitals in China from December 20, 2016, through August 9, 2022. The date of final follow-up was October 30, 2022. The analysis was reported on March 12, 2023. Of 3065 patients with ischemic stroke, 3000 patients with acute mild to moderate stroke within 48 hours of symptom onset were enrolled, after excluding 65 patients who did not meet eligibility criteria or had no randomization outcome. Interventions Within 48 hours after symptom onset, patients were randomly assigned to receive clopidogrel plus aspirin (n = 1541) or aspirin alone (n = 1459) in a 1:1 ratio. Main Outcomes and Measures The primary end point was early neurologic deterioration at 7 days, defined as an increase of 2 or more points in National Institutes of Health Stroke Scale (NIHSS) score, but not as a result of cerebral hemorrhage, compared with baseline. The superiority of clopidogrel plus aspirin to aspirin alone was assessed based on a modified intention-to-treat population, which included all randomized participants with at least 1 efficacy evaluation regardless of treatment allocation. Bleeding events were safety end points. Results Of the 3000 randomized patients, 1942 (64.6%) were men, the mean (SD) age was 65.9 (10.6) years, median (IQR) NIHSS score at admission was 5 (4-6), and 1830 (61.0%) had a stroke of undetermined cause. A total of 2915 patients were included in the modified intention-to-treat analysis. Early neurologic deterioration occurred in 72 of 1502 (4.8%) in the dual antiplatelet therapy group vs 95 of 1413 (6.7%) in the aspirin alone group (risk difference −1.9%; 95% CI, −3.6 to −0.2; P = .03). Similar bleeding events were found between 2 groups. Conclusions and Relevance Among Chinese patients with acute mild to moderate ischemic stroke, clopidogrel plus aspirin was superior to aspirin alone with regard to reducing early neurologic deterioration at 7 days with similar safety profile. These findings indicate that dual antiplatelet therapy may be a superior choice to aspirin alone in treating patients with acute mild to moderate stroke.Trial RegistrationClinicalTrials.gov Identifier: NCT0286900

Research and implementation of IPSEC based on TD-LTE system

Conference Name:2nd International Conference on Mechanical Engineering, Industrial Electronics and Informatization, MEIEI 2013. Conference Address: Chongqing, China. Time:September 14, 2013 - September 15, 2013.Chongqing University of Science and Technology; Computer Science and Electronic Technology International Society; Atlantis press; Chongqing Normal University; Chongqing University of Technology; et alWith the rapid development of Internet technology, network and information security has become increasingly important. After studying the principle of IPSEC(IP Security) and VPN (Virtual Private Network) technology, this paper designs a network architecture which is called S1 in the TD-LTE communication system. The specific packet is securely encrypted by using IPSEC technology between the base station and security gateway. After a lot of tests, the technical solution to achieve IPSEC is proved to be realized and to have a highly efficient and stable characteristic. ? (2013) Trans Tech Publications, Switzerland

A Study on the Distributed Antenna Based Heterogeneous Cognitive Wireless Network Synchronous MAC Protocol

This paper introduces distributed antennas into a cognitive radio network and presents a heterogeneous network. The best contribution of this paper is that it designs a synchronous cognitive MAC protocol (DAHCWNS-MAC protocol: distributed antenna based heterogeneous cognitive wireless network synchronous MAC protocol). The novel protocol aims at combining the advantages of cognitive radio and distributed antennas to fully utilize the licensed spectrum, broaden the communication range, and improve throughput. This paper carries out the mathematical modeling and performance simulation to demonstrate its superiority in improving the network throughput at the cost of increasing antenna hardware costs

The realization of MP3 player system based onmediastreamer2 framework

Conference Name:3rd International Conference on Materials Science and Information Technology, MSIT 2013. Conference Address: Nanjing, Jiangsu, China. Time:September 14, 2013 - September 15, 2013.Trans tech publications inc.; Computer Science and Electronic Technology; BITS Narsampet; Universitatea Politehnica Din BucurestiIn this paper, we modify some interface functions of the open source high quality MPEG audio decoder library (MAD) based on the Mediastreamer2 structure. The MP3 player system can support the normal playing of the local audio files at the same time of decoding. Under the test of S3C6410, the system designing in playing the local MP3 files is available, and with a lower utilization ratio of RAM and CPU. ? (2013) Trans Tech Publications, Switzerland

Automatic liver lesion extraction from CT images based on distance regularized level set evolution and region growing

Conference Name:2014 International Conference on Mechatronics Engineering and Computing Technology, ICMECT 2014. Conference Address: Shanghai, China. Time:April 9, 2014 - April 10, 2014.Engineering Village; et al; INTIEA; National Institute of Technology Rourkela; trans tech publications inc.; Universitatea Politehnica Din BucurestiCurrent diagnosis with computed tomography (CT) imaging relies heavily on doctors' clinical experience and it is difficult to accurately identify and localize lesions from thousands of CT images. Therefore, computer-aided diagnosis with automatic lesion extraction will be helpful for doctors in the diagnosis of liver diseases. In this paper, we proposed a new method for automatic liver lesion extraction from CT images by combining DRLSE (distance regularized level set evolution) and region growing. The method was applied in abdominal CT images with a single liver cancerous lesion and multiple hemangioma lesions at different locations. The results demonstrated the feasibility of our method for automatic lesion extraction with improved diagnostic accuracy and time efficiency. ? (2014) Trans Tech Publications, Switzerland

Research and design of broadband trunking communication server subsystem

Conference Name:2nd International Conference on Mechanical Engineering, Industrial Electronics and Informatization, MEIEI 2013. Conference Address: Chongqing, China. Time:September 14, 2013 - September 15, 2013.Chongqing University of Science and Technology; Computer Science and Electronic Technology International Society; Atlantis press; Chongqing Normal University; Chongqing University of Technology; et alBroadband trunking communication system is a specialized command and scheduling system for mobile communication, which has characteristics such as resources and costs sharing, high-efficient command and scheduling capability and so on. This paper firstly describes the evolution of broadband trunking communication. Based on the study of the system architecture and existing technologies, this paper proposes a way of simplifying the system architecture and elaborates the system framework into four modules including scheduler, server, base station and terminal. In the end, a program of broadband trunking communication server subsystem is designed and realized for voice service based on Linux platform. The results demonstrate the program has advantages of low-delay and high-efficient scheduling capability. ? (2013) Trans Tech Publications, Switzerland